Results 71 to 80 of about 3,909 (203)
Pendrin gene ablation enhances vascular contractility
The FASEB Journal, 2009 Pendrin, encoded by Slc26a4, is expressed in the apical regions of a subset of renal intercalated cells, where it mediates Cl − absorption and HCO 3 − secretion through apical Cl
Roy L. Sutliff +7 more
openaire +1 more source
Frontiers in Medicine, 2021 Background: The utility of urinary extracellular vesicles (uEVs) to faithfully represent the changes of renal tubular protein expression remains unclear. We aimed to evaluate renal tubular sodium (Na+) or potassium (K+) associated transporters expression
Chih-Chien Sung +6 more
doaj +1 more source
Two novel SLC26A4 mutations in Iranian families with autosomal recessive hearing loss [PDF]
, 2012 Objective: Due to the fact that SLC26A4 has been suggested as the second cause of hearing loss (HL) in Iran as well as many other countries, obtaining more comprehensive information about SLC26A4 mutations can facilitate more efficient genetic services ...
Farrokhi, Effat. +7 more
core +1 more source
The Journal of biological chemistry, 2004 Pendred's syndrome is an autosomal recessive disorder characterized by sensorineural deafness, goiter, and impaired iodide organification. It is caused by mutations in the PDS/SLC26A4 gene that encodes pendrin. Functionally, pendrin is a transporter of chloride and iodide in Xenopus oocytes and heterologous mammalian cells and a chloride/base exchanger
Mary P, Gillam +5 more
openaire +2 more sources
Developmental Dynamics, Volume 254, Issue 12, Page 1275-1296, December 2025.Abstract Background Freshwater salinization is an emerging stressor in amphibian populations, and embryonic stages are most vulnerable. To better understand the variation in embryonic osmoregulation, we challenged embryos of two phylogenetically diverse anuran species, Xenopus laevis and Lithobates (Rana) sylvaticus, along a gradient of non‐lethal ...
Kourtnie Whitfield, Erica J. Crespi
wiley +1 more source
Molecular Medicine, 2016 Sequence alterations in the pendrin gene (SLC26A4) leading to functionally affected protein variants are frequently involved in the pathogenesis of syndromic and nonsyndromic deafness.
Vanessa C S de Moraes +8 more
doaj +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion
Nature Communications, 2016 Mutations in pendrin, a plasma membrane transporter, lead to Pendred syndrome, which is associated with hearing loss. Here, Jung et al. show that cell-surface expression of a mutated form of pendrin can be restored by blocking ER-to-Golgi traffic and ...
Jinsei Jung +7 more
doaj +1 more source
Postnatal expression of transport proteins involved in acid-base transport in mouse kidney [PDF]
, 2018 The kidney plays a major role in maintaining and controlling systemic acid-base homeostasis by reabsorbing bicarbonate and secreting protons and acid-equivalents, respectively.
Bonnici, Brenda, Wagner, Carsten
core