Results 81 to 90 of about 3,909 (203)

Colocalization of the (Pro)renin receptor/Atp6ap2 with H+-AT pases in mouse kidney but prorenin does not acutely regulate intercalated cell H+-ATPase activity [PDF]

, 2016
The (Pro)renin receptor (P)RR/Atp6ap2 is a cell surface protein capable of binding and nonproteolytically activate prorenin. Additionally, (P)RR is associated with H+-ATPases and alternative functions in H+-ATPase regulation as well as inWnt signalling ...
Bourgeois, S. (Soline), Danser, A.H.J. (Jan), Daryadel, A. (Arezoo), Figueiredo, M.F.L. (Marta F. L.), Kampik, N.B. (Nicole B.), Lu, X. (Xifeng), Meima, M.E. (Marcel), Mohebbi, N. (Nilufar), Moreira, A.G. (Ana Gomes), Oberli, L. (Lisa), Wagner, C.A. (Carsten)   +10 more
core   +1 more source

Acute regulated expression of pendrin in human urinary exosomes [PDF]

Pflügers Archiv - European Journal of Physiology, 2017
It is well known that pendrin, an apical Cl-/HCO3-exchanger in type B intercalated cells, is modulated by chronic acid-base disturbances and electrolyte intake. To study this adaptation further at the acute level, we analyzed urinary exosomes from individuals subjected to oral acute acid, alkali, and NaCl loading.
Pathare, Ganesh, Dhayat, Nasser, Mohebbi, Nilufar, Wagner, Carsten, Cheval, Lydie, Neuhaus, Thomas, Fuster, Daniel   +6 more
openaire   +4 more sources

Probenecid Pre-treatment Downregulates the Kidney Cl-/HCO3- Exchanger (Pendrin) and Potentiates Hydrochlorothiazide-Induced Diuresis

Frontiers in Physiology, 2018
Background: Probenecid is a uricosuric agent that in addition to exerting a positive ionotropic effect in the heart, blocks the ATP transporter Pannexin 1 and inhibits the Cl-/HCO3- exchanger, pendrin.
Sharon Barone, Sharon Barone, Jie Xu, Jie Xu, Kamyar Zahedi, Kamyar Zahedi, Marybeth Brooks, Manoocher Soleimani, Manoocher Soleimani, Manoocher Soleimani   +9 more
doaj   +1 more source

The miRNA Expression of Urinary Extracellular Vesicles in Patients With Gitelman Syndrome: The Role of hsa‐let‐7d‐3p

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
This study identifies differentially expressed miRNAs in urinary extracellular vesicles and kidney biopsies from Gitelman syndrome patients. In particular, hsa‐let‐7d‐3p is the only upregulated miRNA that negatively regulates NEDD4L, a key modulator of sodium transport.
Chao‐Ting Chen, Shih‐Hua Lin, Min‐Hsiu Chen, Hsin‐Yi Chang, Min‐Hua Tseng, Yii‐Jwu Lo, Kuan‐Chieh Peng, Che‐Chung Huang, Chih‐Chien Sung   +8 more
wiley   +1 more source

Compound Heterozygosity for Two Novel SLC26A4 Mutations in a Large Iranian Pedigree with Pendred Syndrome [PDF]

, 2013
Objectives. The aim of this study was to detect the genetic cause of deafness in a large Iranian family. Due to the importance of SLC26A4 in causing hearing lots, information about the gene mutations can be beneficial in molecular detection and ...
Abdian, Narges., Bagheri, Nader., Farrokhi, Effat., Hashemzadeh-Chaleshtori, Morteza., Noormohammadi, Zahra., Shahbazi, Shirin., Tabatabaiefar, Mohammad Amin., Yazdanpanahi, Nasrin.   +7 more
core   +1 more source

Treating Hearing Loss: From Cochlear Implantation to Gene Therapy

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Cochlear implantation is the primary treatment for deafness, restoring functional hearing in over a million people. Recently, gene therapy has enabled biological hearing restoration in a small number of patients with OTOF‐related mutations. This perspective evaluates both approaches, concluding that cochlear implants will remain the standard for most ...
Fan‐Gang Zeng, Jieyu Qi, Chen‐Chi Wu, Yilai Shu, Renjie Chai   +4 more
wiley   +1 more source

Impaired expression of key molecules of ammoniagenesis underlies renal acidosis in a rat model of chronic kidney disease [PDF]

, 2017
Background Advanced chronic kidney disease (CKD) is associated with the development of renal metabolic acidosis. Metabolic acidosis per se may represent a trigger for progression of CKD.
Bettoni, Carla, Bürki, Remy, Mohebbi, Nilufar, Serra, Andreas L., Wagner, Carsten A., Wang, Xueqi   +5 more
core  

The multiple roles of pendrin in the kidney [PDF]

Nephrology Dialysis Transplantation, 2014
The [Formula: see text] exchanger pendrin (SLC26A4, PDS) is located on the apical membrane of B-intercalated cells in the kidney cortical collecting duct and the connecting tubules and mediates the secretion of bicarbonate and the reabsorption of chloride. Given its dual function of bicarbonate secretion and chloride reabsorption in the distal tubules,
openaire   +2 more sources

Bilateral Enlarged Vestibular Aqueduct: Auditory, Genetic and Radiological Characterization, and Benefits of Cochlear Implants

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 5, Page 1215-1227, November 2025.
Abstract Objective The study aimed to describe the auditory phenotype of patients with bilateral enlarged vestibular aqueduct, including benefits of cochlear implantation, and to look for genotype‐phenotype correlation. Study Design Retrospective single‐center study. Setting Tertiary adult reference center.
Augustin Vigouroux, Benjamin Glemain, Renato Torres, Laurence Jonard, Natalie Loundon, Evelyne Ferrary, Isabelle Mosnier, Hannah Daoudi, Sandrine Marlin, Ghizlene Lahlou   +9 more
wiley   +1 more source

Superparamagnetic iron oxide polyacrylic acid coated {\gamma}-Fe2O3 nanoparticles does not affect kidney function but causes acute effect on the cardiovascular function in healthy mice

, 2012
This study describes the distribution of intravenously injected polyacrylic acid (PAA) coated {\gamma}-Fe2O3 NPs (10 mg kg-1) at the organ, cellular and subcellular levels in healthy BALB/cJ mice and in parallel addresses the effects of NP injection on ...
Baatrup, Erik, Berret, Jean-Francois, Bie, Peter, Fresnais, Jérome, Frische, Sebastian, Hansen, Pernille B. L., Iversen, Nina K., Laustsen, Christoffer, Pedersen, Michael, Thomsen, Karen, Wang, Tobias   +10 more
core   +2 more sources