Results 1 to 10 of about 35,186 (219)
Antibiotics, 2021 Chelant agents are the mainstay of treatment in copper-associated hepatitis in humans, where D-penicillamine is the chelant agent of first choice. In veterinary medicine, the use of D-penicillamine has increased with the recent recognition of copper ...
Michela Pugliese +6 more
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Safety of penicillamine and trientine in the treatment of Wilson's disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database. [PDF]
PLoS ONEBackgroundPenicillamine(D-Penicillamine) and trientine are first-line therapies for Wilson's Disease (WD), yet real-world data on their adverse events (AEs) remain scarce.
Wenlong Qian +12 more
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Controlled administration of penicillamine reduces radiation exposure in critical organs during 64Cu-ATSM internal radiotherapy: a novel strategy for liver protection. [PDF]
PLoS ONE, 2014 PURPOSE: (64)Cu-diacetyl-bis (N (4)-methylthiosemicarbazone) ((64)Cu-ATSM) is a promising theranostic agent that targets hypoxic regions in tumors related to malignant characteristics.
Yukie Yoshii +10 more
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Frontiers in Pharmacology, 2022 Background: Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients.Methods: We conducted a systemic review and ...
Shan Tang +10 more
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Angiostatin generating capacity and anti-tumour effects of D-penicillamine and plasminogen activators [PDF]
BMC Cancer, 2006 Background Upregulation of endogenous angiostatin levels may constitute a novel anti-angiogenic, and therefore anti-tumor therapy. In vitro, angiostatin generation is a two-step process, starting with the conversion of plasminogen to plasmin by ...
Maass Cathy N +5 more
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Comparative review of copper-associated chronic hepatitis in dogs and Wilson disease in humans [PDF]
Frontiers in Veterinary ScienceCopper-associated chronic hepatitis (CAH) in dogs and Wilson disease (WD) in humans are progressive hepatic disorders caused by copper accumulation. Although both diseases share similar pathomechanisms of copper-induced liver injury, they diverge in some
Tarini Ullal +3 more
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Penicillamine ameliorates intestinal barrier damage in dextran sulfate sodium-induced experimental colitis mice by inhibiting cuproptosis [PDF]
Frontiers in ImmunologyBackgroundCuproptosis is a copper-dependent form of cell death. However, its role in ulcerative colitis (UC) remains unknown.AimTo investigate whether cuproptosis is involved in UC and whether penicillamine (PA) improves colitis in mice by inhibiting ...
Jiaze Ma +8 more
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Annals of Indian Academy of Neurology, 2022 Background: Most centers in developing countries prefer chelation therapy with D-penicillamine for the management of Wilson's disease (WD) because of its easy availability and affordability. Neurological worsening following treatment with D-penicillamine
Madhan Kumar +5 more
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Penicillamine Nephropathy [PDF]
Nephron, 1980 8 patients who developed proteinuria whilst receiving penicillamine for rheumatoid arthritis have been studied. Light microscopy of renal biopsy specimens showed evidence of an extramembranous nephropathy in 6 cases, with epimembranous spikes infrequently described previously in association with penicillamine.
J H, Ross, F, McGinty, D G, Brewer
openaire +2 more sources