Results 1 to 10 of about 39,709 (281)

Penicillamine ameliorates intestinal barrier damage in dextran sulfate sodium-induced experimental colitis mice by inhibiting cuproptosis [PDF]

Frontiers in Immunology
BackgroundCuproptosis is a copper-dependent form of cell death. However, its role in ulcerative colitis (UC) remains unknown.AimTo investigate whether cuproptosis is involved in UC and whether penicillamine (PA) improves colitis in mice by inhibiting ...
Jiaze Ma, Yimeng Ma, Shuangshuang Wang, Wenwen Tang, Chen Chen, Yang Li, Yang Li, Yugen Chen, Tuo Chen   +8 more
doaj   +4 more sources

Management of children and adolescents with Wilson Disease and neurological worsening following D–Penicillamine therapy: A single centre experience

Annals of Indian Academy of Neurology, 2022
Background: Most centers in developing countries prefer chelation therapy with D-penicillamine for the management of Wilson's disease (WD) because of its easy availability and affordability. Neurological worsening following treatment with D-penicillamine
Madhan Kumar, T P Murugan, Arul P Lionel, Maya M Thomas, Pavithra Mannam, Sangeetha Yoganathan   +5 more
doaj   +2 more sources

Controlled administration of penicillamine reduces radiation exposure in critical organs during 64Cu-ATSM internal radiotherapy: a novel strategy for liver protection. [PDF]

PLoS ONE, 2014
PURPOSE: (64)Cu-diacetyl-bis (N (4)-methylthiosemicarbazone) ((64)Cu-ATSM) is a promising theranostic agent that targets hypoxic regions in tumors related to malignant characteristics.
Yukie Yoshii, Hiroki Matsumoto, Mitsuyoshi Yoshimoto, Takako Furukawa, Yukie Morokoshi, Chizuru Sogawa, Ming-Rong Zhang, Hidekatsu Wakizaka, Hiroshi Yoshii, Yasuhisa Fujibayashi, Tsuneo Saga   +10 more
doaj   +2 more sources

D-Penicillamine: The State of the Art in Humans and in Dogs from a Pharmacological and Regulatory Perspective

Antibiotics, 2021
Chelant agents are the mainstay of treatment in copper-associated hepatitis in humans, where D-penicillamine is the chelant agent of first choice. In veterinary medicine, the use of D-penicillamine has increased with the recent recognition of copper ...
Michela Pugliese, Vito Biondi, Enrico Gugliandolo, Patrizia Licata, Alessio Filippo Peritore, Rosalia Crupi, Annamaria Passantino   +6 more
doaj   +2 more sources

Safety of penicillamine and trientine in the treatment of Wilson's disease: An analysis of the FDA Adverse Event Reporting System (FAERS) database. [PDF]

PLoS ONE
BackgroundPenicillamine(D-Penicillamine) and trientine are first-line therapies for Wilson's Disease (WD), yet real-world data on their adverse events (AEs) remain scarce.
Wenlong Qian, Kou Xu, Shuo Li, Zhuo Zhang, Xiaoxiao Hou, Bingjie Min, Jia Ling, Xinyu Zhu, Hui Zhou, Wenjuan Xu, Wenming Yang, Shijian Cao, Yonghua Chen   +12 more
doaj   +2 more sources

Comparison of the Effectiveness and Safety of d-Penicillamine and Zinc Salt Treatment for Symptomatic Wilson Disease: A Systematic Review and Meta‐Analysis

Frontiers in Pharmacology, 2022
Background: Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients.Methods: We conducted a systemic review and ...
Shan Tang, Li Bai, Li Bai, Wei Hou, Zhongjie Hu, Xinyue Chen, Jing Zhao, Chen Liang, Wei Zhang, Zhongping Duan, Sujun Zheng   +10 more
doaj   +2 more sources

Comparative review of copper-associated chronic hepatitis in dogs and Wilson disease in humans [PDF]

Frontiers in Veterinary Science
Copper-associated chronic hepatitis (CAH) in dogs and Wilson disease (WD) in humans are progressive hepatic disorders caused by copper accumulation. Although both diseases share similar pathomechanisms of copper-induced liver injury, they diverge in some
Tarini Ullal, Eunju April Choi, Dorina Gui, Valentina Medici   +3 more
doaj   +2 more sources

Pemphigus Vulgaris Associated with Rheumatoid Arthritis in a Patient not Taking Penicillamine

Journal of Dental Research, Dental Clinics, Dental Prospects, 2012
D-penicillamine is one of the disease-modifying anti-rheumatic drugs (DMARDs). Drug-induced pemphigus is not frequently associated with D-penicillamine, and to date, the number of reported cases is about a hundred. Most reports of Dpenicillamine-induced
Narges Gholizadeh, Ali Taghavi Zenouz, Hossein Eslami   +2 more
doaj   +2 more sources

D-Penicillamine/Dihydroquercetin Dual-Loaded Metal-Organic Framework as a Microenvironment Copper Regulator for Enhancing the Therapeutic Efficacy of Polyphenolic Antioxidant in Alzheimer's Disease. [PDF]

Molecules
Wu X, Huang G, Chen L, Xie Y, Ding Q, Xi E, Zhao Y, Gao N.   +7 more
europepmc   +3 more sources

Penicillamine

Reactions Weekly
Mejias SG, Patel P, Ramphul K.
europepmc   +4 more sources