Results 51 to 60 of about 27,456 (253)

Synthesis and anti-intracellular Copper overload evaluation of Nanoconjugated D-penicillamine –Dendrimer in Wilson’s model cells

مجله دانشگاه علوم پزشکی گرگان, 2016
Background and Objective: Wilson’s disease (WD) is caused by mutation to the cooer-transporting gene ATP7B. Chelation therapy is the main protochol of treatment for patients with Wilson’s disease.
Fani N, Shafiee Ardestani M, Yaghmaei P, Assadi A, Barzegar Behrouz A   +4 more
doaj  

Acute kidney injury and morbi‐mortality associated with “triple whammy” combination: Systematic review and meta‐analysis

British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3031-3041, November 2025.
Aims “Triple whammy” (TW) refers to the concomitant use of diuretics, renin‐angiotensin‐aldosterone system inhibitors (RAASI) and non‐steroidal anti‐inflammatory drugs (NSAIDs). The aim of this article is to analyse the association between TW exposure and acute kidney injury (AKI), among other morbi‐mortality outcomes.
Dulce María Calvo, Luis Carlos Saiz, Leire Leache, Maria Concepción Celaya, Marta Gutiérrez‐Valencia   +4 more
wiley   +1 more source

Long-term effects of a combination of D-penicillamine and zinc salts in the treatment of Wilson’s disease in children

Experimental and Therapeutic Medicine, 2013
The aim of this study was to investigate the effectiveness of a high-dose zinc sulfate and low-dose D-penicillamine combination in the treatment of pediatric Wilson’s disease (WD). A retropective chart review of 65 patients with WD was conducted.
Hong-I. Chang, Aijing Xu, Zhi-hong Chen, Ying Zhang, Fei Tian, Tang Li   +5 more
semanticscholar   +1 more source

Agreement Between Self‐Reported Antirheumatic Medications and Pharmaceutical Claims in an Australian Inflammatory Arthritis Cohort

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
Objective To assess agreement between prescription claims data and self‐reported medication use via longitudinal questionnaires in the Australian Rheumatology Association Database inflammatory arthritis cohort and to identify predictors of discordant self‐reports.
Tom Lynch, Claire Barrett, Rachel Black, Rachelle Buchbinder, Graeme Carroll, Vibhasha Chand, Catherine L. Hill, Marissa Lassere, Sue Lester, Oscar Russell, Premarani Sinnathurai, Lyn March   +11 more
wiley   +1 more source

Evaluation of Protective Effect of Penicillamine on Silver Nanoparticles-Induced Oxidative Stress in BALB/c Mice

İstanbul Üniversitesi Veteriner Fakültesi Dergisi, 2015
Despite the negative effects of silver nanoparticles, their application is growing rapidly, so this study was designed to investigate the adverse effects of nanosilver administration on histopathological changes and biochemical parameters as well as ...
Fatemeh NAMAZI, Mehdi FAZELI, Yalda ZOLGHADRI, Saeed MOHAMMADINEZHAD, Saeed NAZIFI   +4 more
doaj   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, Volume 12, Issue 40, October 27, 2025.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

An Elegant Method of One‐Pot Ligation‐Desulfurization for High‐Yielding Chemical Protein Synthesis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
A one‐pot native chemical ligation and desulfurization method has been developed for efficient chemical protein synthesis. This unique approach uses bromoacetamide and N‐acetyl cysteine to selectively quench arylthiol post native chemical ligation.
Vishal Malik, Abhisek Kar, Anandh Muthiah Venkatachalam, Kalyaneswar Mandal   +3 more
wiley   +1 more source

Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast‐Like Synoviocyte

International Journal of Rheumatic Diseases, Volume 28, Issue 10, October 2025.
ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic synovitis and skeletal joint deformities, often accompanied by systemic symptoms. Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids ...
Xiaorong Zhi, Hong Zhu, Xiaoyan Sun, Zhaoxia Wang, Lin Wang, Guanhua Song   +5 more
wiley   +1 more source

Update on Genetic Chorea

European Journal of Neurology, Volume 32, Issue 10, October 2025.
This review provides an updated clinical and genetic framework for the differential diagnosis of hereditary chorea. It guides neurologists through the interpretation of phenomenology, ancillary tests, and appropriate genetic techniques to achieve an accurate and timely diagnosis.
Jesús Pérez‐Pérez, Gonzalo Olmedo‐Saura, Saül Martínez‐Horta, Sara Bernal, Javier Pagonabarraga, Jaime Kulisevsky   +5 more
wiley   +1 more source

Treatment patterns in a real-world cohort of patients with Wilson disease in the United States

Frontiers in Gastroenterology
BackgroundWilson disease (WD) is a rare and potentially fatal genetic disorder caused by accumulation of toxic levels of copper. Current treatments include chelating agents and/or zinc.
Valentina Medici, Nehemiah Kebede, Jennifer Stephens, Mary Kunjappu, John M. Vierling   +4 more
doaj   +1 more source