Functional redundancy of division specific penicillin-binding proteins in Bacillus subtilis. [PDF]
Mol Microbiol, 2017 Bacterial cell division involves the dynamic assembly of a diverse set of proteins that coordinate the invagination of the cell membrane and synthesis of cell wall material to create the new cell poles of the separated daughter cells.
Sassine J +5 more
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Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance The antimicrobial effect of copper has been known since ancient times and it is well known that copper alloy surfaces kill various disease-causing bacteria, fungi, and viruses, preventing the spread of antibiotic resistance through ...
Peters K +8 more
europepmc +2 more sources
Resistance to β-lactam antibiotics conferred by point mutations in penicillin-binding proteins PBP3, PBP4 and PBP6 in Salmonella enterica. [PDF]
PLoS ONE, 2014 Penicillin-binding proteins (PBPs) are enzymes responsible for the polymerization of the glycan strand and the cross-linking between glycan chains as well as the target proteins for β-lactam antibiotics.
Song Sun, Maria Selmer, Dan I Andersson
doaj +2 more sources
Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis. [PDF]
Sci Rep, 2017 Bacteria utilize specialized multi-protein machineries to synthesize the essential peptidoglycan (PG) cell wall during growth and division. The divisome controls septal PG synthesis and separation of daughter cells. In E.
Leclercq S +7 more
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Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsSalmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh +4 more
doaj +2 more sources
Boronate-Based Inhibitors of Penicillin-Binding Proteins: An Underestimated Avenue for Antibiotic Discovery? [PDF]
PharmaceuticalsPenicillin-binding proteins (PBPs) are essential enzymes involved in bacterial cell wall biosynthesis and represent the primary targets of β-lactam antibiotics.
Valentina Villamil +4 more
doaj +2 more sources
Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles [PDF]
Microbial Cell, 2018 The bacterial cell wall preserves cell integrity in response to external insults and the internal turgor pressure. The major component of the cell wall is the peptidoglycan (PG); a giant macromolecule formed by glycan chains cross-linked by short ...
Sónia Castanheira +3 more
doaj +2 more sources
Penicillin-binding proteins exhibit functional redundancy during asymmetric cell division in Clostridioides difficile [PDF]
Journal of BacteriologyPeptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the polymerization of glycan strands by shape, elongation, division, and sporulation (SEDS) family glycosyltransferases and ...
Shailab Shrestha +4 more
doaj +2 more sources
Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in Salmonella [PDF]
Infection and ImmunityType III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold.
Sónia Castanheira +3 more
doaj +2 more sources
Role of Pseudomonas aeruginosa Low-Molecular-Mass Penicillin-Binding Proteins in AmpC Expression, β-Lactam Resistance, and Peptidoglycan Structure [PDF]
Antimicrobial Agents and Chemotherapy, 2015 Alaa Ropy +6 more
openalex +2 more sources