Restricted Sequence Variation in
mSphere, 2020 A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding protein (PBP) PBP2x. To determine whether this is an isolated case or reflects a broader prevalence of mutations that might ...
Andrew Hayes +4 more
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Relationship between Penicillin-Binding Proteins Alterations and β-Lactams Non-Susceptibility of Diseased Pig-Isolated Streptococcus suis [PDF]
Antibiotics, 2023 Streptococcus suis is a zoonotic pathogen causing disease in both animals and humans, and the emergence of increasingly resistant bacteria to antimicrobial agents has become a significant challenge globally. The objective of this study was to investigate
Kamonwan Lunha +5 more
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Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm [PDF]
mSphere, 2022 Penicillin binding proteins (PBPs) have been extensively studied due to their importance to the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used class of antibiotics, the β-lactams. The existing paradigm asserts that
Gaurav Kumar +4 more
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Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins [PDF]
eLife, 2021 Peptidoglycan is an essential component of the bacterial cell envelope that surrounds the cytoplasmic membrane to protect the cell from osmotic lysis. Important antibiotics such as β-lactams and glycopeptides target peptidoglycan biosynthesis.
Víctor M Hernández-Rocamora +5 more
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Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsSalmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh +4 more
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Boronate-Based Inhibitors of Penicillin-Binding Proteins: An Underestimated Avenue for Antibiotic Discovery? [PDF]
PharmaceuticalsPenicillin-binding proteins (PBPs) are essential enzymes involved in bacterial cell wall biosynthesis and represent the primary targets of β-lactam antibiotics.
Valentina Villamil +4 more
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Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles [PDF]
Microbial Cell, 2018 The bacterial cell wall preserves cell integrity in response to external insults and the internal turgor pressure. The major component of the cell wall is the peptidoglycan (PG); a giant macromolecule formed by glycan chains cross-linked by short ...
Sónia Castanheira +3 more
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Penicillin-binding proteins exhibit functional redundancy during asymmetric cell division in Clostridioides difficile [PDF]
Journal of BacteriologyPeptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the polymerization of glycan strands by shape, elongation, division, and sporulation (SEDS) family glycosyltransferases and ...
Shailab Shrestha +4 more
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Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in Salmonella [PDF]
Infection and ImmunityType III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold.
Sónia Castanheira +3 more
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Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials [PDF]
Antibiotics, 2016 Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex ...
Eric Sauvage, Mohammed Terrak
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