Results 131 to 140 of about 401,752 (293)

Substrate entering and product leaving trajectories predict an engulfing dynamic for the major conformational change of the β-lactam acylase

, 2008
It is still a major challenge to acquire insight into the conformational changes between the ground state and the transition state of an enzyme, although conformational fluctuation within interconverting conformers has been widely investigated (1-4 ...
Xi Huang, Jun Yin, Wei-Hong Jiang, Zixin Deng, Guo-Ping Zhao   +4 more
core  

The role of penicillin binding proteins in the resistance of neisseria [PDF]

, 1991
ThesisNeisseria gonorrhoeae, an organism which previously was found to be extremely sensitive to penicillin and other antibiotics is becoming increasingly resistant.
Wende, Linda
core  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Portadores nasales de sthaphylococcus aereus meticilino resistente en contacto con pacientes pediátricos con enfermedad diseminada adquirida en la comunidad. [PDF]

MedUNAB, 2007
Background: sthaphylococcus aereus (SA) is an important cause of disese in pediatric population. Methicillin resistant sthaphylococcus aereus (MRSA) infection have spread worldwide coth health care and comunity setting. Asyntimatic colonization with MRSA
Luis Miguel Sosa Ávila, Martha Lucía Incapié   +1 more
doaj  

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Penicillin-binding proteins in the cyanelles of Cyanophora paradoxa, a eukaryotic photoautotroph sensitive to β-lactam antibiotics

, 1987
Cyanophora paradoxa is a eukaryotic protist sensitive to β-lactam antibiotics, most likely as a consequence of the binding of the drugs to a set of 7 proteins, analogous to eubacterial penicillin-binding proteins (PBPs), located in the envelope of the C.
Jose Berenguer, Rojo, Fernando, de Pedro, Miguel A., Pfanzagl, Beatrix, Löffelhardt, Wolfgang, Beatrix Pfanzagl, Fernando Rojo, Miguel A. de Pedro, Berenguer, Jose, Wolfgang Löffelhardt   +9 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Evolution of Ceftriaxone Resistance of Penicillin-Binding Proteins 2 Revealed by Molecular Modeling. [PDF]

Int J Mol Sci, 2022
Krivitskaya AV, Khrenova MG.
europepmc   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

β-Lactam Resistance in ESKAPE Pathogens Mediated Through Modifications in Penicillin-Binding Proteins: An Overview. [PDF]

Infect Dis Ther, 2023
Sethuvel DPM, Bakthavatchalam YD, Karthik M, Irulappan M, Shrivastava R, Periasamy H, Veeraraghavan B.   +6 more
europepmc   +1 more source