Results 111 to 120 of about 204,146 (354)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers [PDF]

, 1985
In plasma and urine of 10 healthy volunteers after intravenous administration of 4 g mezlocillin and piperacillin, respectively, the parent compounds as well as degradation products were assayed by high-performance liquid chromatography. Ioxitalamic acid,
Bartoschik-Wich, B., Grobecker, H., Kees, Frieder K., Meyer, G. P., Naber, K. G., Stockmann, P.   +5 more
core  

Antibiotic resistance in the environment, with particular reference to MRSA [PDF]

, 2008
The introduction of β-lactam antibiotics (penicillins and cephalosporins) in the 1940s and 1950s probably represents the most dramatic event in the battle against infection in human medicine.
Aarestrup, Abraham, Agerso, Agustía, Anthonisen, Archer, Armand‐Lefevre, Asensio, Aubry‐Damon, Baptiste, Bass, Berg, Berghash, Bernabé, Biberstein, Boag, Bonnet, Boxall, Boyle‐Vavra, Briggs, Brinas, Brinas, Brinas, Burd, Burd, Burrus, Busato, Cefai, Chapin, Chee‐Sanford, Chen, Coello, Coffey, Couto, Couto, Cove, Dar, Daum, Davidson, De Liguoro, de Neeling, De Oliveira, Decousser, Devriese, Dingwell, Dunny, Eady, Ensor, Erskine, Fanaro, Fluit, Fox, Freter, Gaze, Gentilini, Germida, Gibbs, Gill, Golet, Gotz, Griggs, Guler, Halbert, Hall, Hamscher, Hansen‐Nord, Hanssen, Hanssen, Hardy, Hartman, Hasman, Hawes, Hawkey, Henriques, Herold, Heuer, Heuer, Hiramatsu, Hoekstra, Hollander, Holmes, Huijsdens, Hutchison, Ito, Ito, Jensen, Kapur, Katayama, Kirby, Kloos, Kummerer, Kuroda, Lee, Lee, Leverstein‐van Hall, Levy, Levy, Lilenbaum, Lindsay, Livermore, Lopes, Machado, Mahamoud, Manian, Marangon, McDonnell, Menzies, Mesa, Morales, Nandi, Neely, Nemergut, Nield, Nordmann, Owen, Owens, Partridge, Patel, Paulsen, Peacock, Pengov, Piddock, Piddock, Pirnay, Poirel, Poirel, Poirel, Poirel, Rahme, Raviglione, Recchia, Roberson, Robicsek, Rodriguez, Sapkota, Sasatsu, Sato, Sato, Segal, Seguin, Shea, Shiraki, Shukla, Sidhu, Sidhu, Singer, Smalla, Smit, Smith, Sorum, Stokes, Tennstedt, Tiemersma, Tikofsky, Tomlin, Top, Turtura, Turutoglu, van Den Bogaard, van den Bogaard, van Duijkeren, van Duijkeren, Vengust, Voss, Waldron, Weese, Weese, Weese, Weigel, White, Witte, Witte   +171 more
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Penicillin Allergy: The Impact of a False Diagnosis

Acta Médica Portuguesa, 2019
N/a.
Bárbara Kong Cardoso, Sofia Martins Farinha, Marta Martins, Bárbara Lobão, Elza Tomaz, Filipe Inácio   +5 more
doaj   +1 more source

Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial [PDF]

, 2012
Objective: To evaluate the effectiveness and costs of a multifaceted flexible educational programme aimed at reducing antibiotic dispensing at the practice level in primary care.<p></p> Design: Randomised controlled trial with general ...
C. C. Butler, D. Cohen, D. Gillespie, F. Dunstan, J. Evans, J. Hayes, K. Hood, L. Moore, M. F. Alam, M. Hare, M. R. Evans, M.-J. Bekkers, R. Howe, S. A. Simpson, s. l. i. e. a. p. health, S. Rollnick   +15 more
core   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The effect of vortioxetine on penicillin-induced epileptiform activity in rats

Arquivos de Neuro-Psiquiatria
Vortioxetine is a multimodal antidepressant agent that modulates 5-HT receptors and inhibits the serotonin transporter. It is indicated especially in cases of major depressive disorder related to cognitive dysfunction.
Muhammed Nur ÖGÜN, Ayhan ÇETİNKAYA, Ersin BEYAZÇİÇEK   +2 more
doaj   +1 more source

Analysis of antibacterial agents consumption in a Brazilian southeastern hospital complex from 2018 to 2021 [PDF]

Brazilian Journal of Pharmaceutical Sciences
Healthcare during the COVID-19 pandemic may have led to the inappropriate use of antimicrobial agents and contributed to elevated multidrug resistance.
Giuliana Amanda de Oliveira, Adriano Max Moreira Reis   +1 more
doaj   +1 more source