FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Causal treatment of acute and chronic tonsillar disease
Медицинский совет, 2014 Bacterial lesion in the oropharynx is a pressing issue in otorhinolaryngology. After flu and acute respiratory infections, sore throat and chronic tonsillitis are the most common human diseases, the prevalence of which, as well as a high probability of a
A. I. Kryukov +3 more
doaj +1 more source
Three innovations of next-generation antibiotics: evolvability, specificity, and non-immunogenicity [PDF]
arXiv, 2022 Antimicrobial resistance is a silent pandemic that is being exacerbated by the uncontrolled use of antibiotics. Since the discovery of penicillin, we have been largely dependent on microbe-derived small molecules to treat bacterial infections. However, the golden era of antibiotics is coming to an end as the emergence and spread of antimicrobial ...
arxiv
Consumption of antibiotics within ambulatory care in Malta [PDF]
, 2011 Background: Antibiotic use is recognised as the most important driver for the development of antimicrobial resistance in community pathogens. Surveillance is therefore critical for improvement programmes.
Borg, Michael Angelo, Zarb, Peter
core
Antibacterial prophylaxis of surgical site infections in oral surgery: not only and not always systemic antibiotics [PDF]
, 2015 Antibacterial prophylaxis is a set of treatment measures, including antibiotic prophylaxis, under surgeon’s responsibility. If local measures are always to be applied, antibiotic prophylaxis administration needs a careful case selection in order to avoid
Pippi, Roberto
core +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
arXiv, 2023 Serendipity plays an important role in scientific discovery. Indeed, many of the most important breakthroughs, ranging from penicillin to the electric battery, have been made by scientists who were stimulated by a chance exposure to unsought but useful information.
arxiv
Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017 [PDF]
, 2018 Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms.
Aghdassi, S. +69 more
core +7 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Convection shapes the trade-off between antibiotic efficacy and the selection for resistance in spatial gradients [PDF]
, 2017 Since penicillin was discovered about 90 years ago, we have become used to using drugs to eradicate unwanted pathogenic cells. However, using drugs to kill bacteria, viruses or cancer cells has the serious side effect of selecting for mutant types that survive the drug attack.
arxiv +1 more source