Results 101 to 110 of about 258,688 (126)

Stable gastric pentadecapeptide BPC 157 and bupivacaine

European Journal of Pharmacology, 2016
Bupivacaine toxicity following accidental overdose still lacks therapeutic solution. However, there are major arguments for testing BPC 157 against bupivacaine toxicity in vivo in rats, in particular, and then finally, in vitro. These are: the lack of any known BPC 157 toxicity, a lifesaving effect via the mitigation of arrhythmias in rats underwent ...
Živanović-Posilović, Gordana, Balenović, Diana, Barišić, Ivan, Strinić, Dean, Stambolija, Vasilije, Udovičić, Mario, Uzun, Sandra, Drmić, Domagoj, Vlainić, Josipa, Lovrić Benčić, Martina, Sindić, Aleksandra, Seiwerth, Sven, Sikirić, Predrag   +12 more
openaire   +3 more sources

Stable Gastric Pentadecapeptide BPC 157 and NO-System

2023
Stable gastric pentadecapeptide BPC 157 is known with very safe profile when used to be in ulcerative colitis and now multiple sclerosis trial, lethal dose (LD1) not achieved. Its pleiotropic beneficial effects were largely combined with its particular modulatory effect on NO-system functions, providing that BPC 157 may counteract adverse effect of ...
Sikirić, Predrag, Boban Blagaić, Alenka, Tvrdeić, Ante, Krezić, Ivan, Gojković, Slaven, Žižek, Helena, Sikirić, Sunčana, Štrbe, Sanja, Smoday, Ivan Maria, Lovrić, Eva, Škrtić, Anita, Seiwerth, Sven   +11 more
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Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy

European Journal of Pharmacology, 2013
Esophagocutaneous fistulas are a failure of the NO-system, due to NO-synthase blockage by the NOS-blocker L-NAME consequently counteracted by l-arginine and gastric pentadecapeptide BPC 157 (l-arginine
Cesarec, Vedran, Becejac, Tomislav, Misic, Marija, Djakovic, Zeljko, Olujic, Danijela, Drmic, Domagoj, Brcic, Luka, Rokotov, Dinko Stancic, Seiwerth, Sven, Sikiric, Predrag   +9 more
openaire   +3 more sources

Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications [PDF]

Current Neuropharmacology, 2016
Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple ...
Martina Lovric Bencic, Domagoj Drmic, Josipa Vlainic   +2 more
exaly   +3 more sources

Stable Gastric Pentadecapeptide BPC 157-NO-system Relation

Current Pharmaceutical Design, 2014
We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157's particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić - Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Stupnišek, Marijana, Šuran, Jelena, Barišić, Ivan, Džidić, Senka, Vrčić, Hrvoje, Šebečić, Božidar   +18 more
openaire   +4 more sources

Toxicity by NSAIDs. Counteraction by Stable Gastric Pentadecapeptide BPC 157

Current Pharmaceutical Design, 2012
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić-Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Safić, Hana, Šuran, Jelena, Rak, Davor, Džidić, Senka, Vrčić, Hrvoje, Sebečić, Božidar   +18 more
openaire   +3 more sources

Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats

Digestive Diseases and Sciences, 2008
The gastric pentadecapeptide BPC 157, which was shown to be safe as an antiulcer peptide in trials for inflammatory bowel disease (PL14736, Pliva), successfully healed intestinal anastomosis and fistula in rat. Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth
Robert Klicek, Marijana Coric, Marko Sever   +2 more
exaly   +5 more sources

Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: A relation with NO-system

Regulatory Peptides, 2009
Pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419) reversed congestive heart failure and various arrhythmias, influenced the NO-system and showed no proarrhythmic effect. In therapy analogy, we challenged rats with digitalis, to show attenuation by BPC 157 and the relation between the NO-system and digitalis toxicity. (i). BPC 157 prophylactic effect.
Marijana Coric, Martina Lovric Bencic, Íngrid Prkacin   +2 more
exaly   +4 more sources

Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157

Current Medicinal Chemistry, 2012
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a ...
P, Sikiric, S, Seiwerth, R, Rucman, B, Turkovic, D S, Rokotov, L, Brcic, M, Sever, R, Klicek, B, Radic, D, Drmic, S, Ilic, D, Kolenc, V, Stambolija, Z, Zoricic, H, Vrcic, B, Sebecic   +15 more
openaire   +2 more sources

Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury

Regulatory Peptides, 2010
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm nerve segment resected) directly into the tube ...
Gjurašin, Miroslav, Miklić, Pavle, Župančić, Božidar, Perović, Darko, Žarković, Kamelija, Brčić, Luka, Kolenc, Danijela, Radić, Božo, Seiwerth, Sven, Sikirić, Predrag   +9 more
openaire   +2 more sources