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Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications [PDF]

Current Neuropharmacology, 2016
Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple ...
Martina Lovric Bencic, Josipa Vlainic, Igor Filipcic   +2 more
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Toxicity by NSAIDs. Counteraction by Stable Gastric Pentadecapeptide BPC 157

Current Pharmaceutical Design, 2012
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić-Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Safić, Hana, Šuran, Jelena, Rak, Davor, Džidić, Senka, Vrčić, Hrvoje, Sebečić, Božidar   +18 more
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Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats

Digestive Diseases and Sciences, 2008
The gastric pentadecapeptide BPC 157, which was shown to be safe as an antiulcer peptide in trials for inflammatory bowel disease (PL14736, Pliva), successfully healed intestinal anastomosis and fistula in rat. Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth
Sever, Marko, Kliček, Robert, Radić, Božo, Brčić, Luka, Zoričić, Ivan, Drmić, Domagoj, Ivica, Mihovil, Barišić, Ivan, Ilić, Spomenko, Berkopić, Lidija, Boban Blagaić, Alenka, Ćorić, Marijana, Kolenc, Danijela, Vrčić, Hrvoje, Anić, Tomislav, Seiwerth, Sven, Sikirić, Predrag   +16 more
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Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157

Current Medicinal Chemistry, 2012
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a ...
P, Sikiric, S, Seiwerth, R, Rucman, B, Turkovic, D S, Rokotov, L, Brcic, M, Sever, R, Klicek, B, Radic, D, Drmic, S, Ilic, D, Kolenc, V, Stambolija, Z, Zoricic, H, Vrcic, B, Sebecic   +15 more
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Traumatic brain injury in mice and pentadecapeptide BPC 157 effect

Regulatory Peptides, 2010
Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported, improved muscle crush injury. After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with ...
Tudor, Mario, Jandrić, Ivan, Marović, Anton, Gjurašin, Miroslav, Perović, Darko, Radić, Božo, Boban Blagaić, Alenka, Kolenc, Danijela, Brčić, Luka, Žarković, Kamelija, Seiwerth, Sven, Sikirić, Predrag   +11 more
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Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury

Regulatory Peptides, 2010
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm nerve segment resected) directly into the tube ...
Gjurašin, Miroslav, Miklić, Pavle, Župančić, Božidar, Perović, Darko, Žarković, Kamelija, Brčić, Luka, Kolenc, Danijela, Radić, Božo, Seiwerth, Sven, Sikirić, Predrag   +9 more
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The Role of Pentadecapeptide BPC 157 in angiogenesis and NO-synthesis

1997
A clear protection of G-I tract and an evident anti-inflammatory effect were shown for a novel stomach pentadecapeptide BPC(i.p./i.g.) in comparison with several reference standards in various ulcer models alog with a protection of endothelium. Thus, in the first experiments we evaluated whether this pentadecapeptide and other gastroprotective agents ...
Sikirić, Predrag, Hanževački, Miro, Seiwerth, Sven, Grabarević, Željko, Turković, Branko, Ručman, Rudolf, Petek, Marina, Miše, Stjepan, Rotkvić, Ivo, Jagić, Vjekoslav, Šeparović, Jadranka, Konjevoda, Paško, Petrov, G., Prkačin, Ingrid, Zoričić, Ivan, Perović, Darko, Bratulić, Mirna, Artuković, Branka, Tišljar, Marina   +18 more
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Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula

European Journal of Pharmacology, 2016
To establish the effects of BPC 157 on the healing of rat colovesical fistulas, Wistar Albino male rats were randomly assigned to different groups. BPC 157, a stable gastric pentadecapeptide, has been used in clinical applications-specifically, in ulcerative colitis-and was successful in treating both external and internal fistulas.
Grgić, Tihomir, Grgić, Dora, Drmić, Domagoj, Zenko Sever, Anita, Petrović, Igor, Sučić, Mario, Kokot, Antonio, Kliček, Robert, Sever, Marko, Seiwerth, Sven, Sikirić, Predrag   +10 more
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Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats

Life Sciences, 2016
Rectovaginal fistula is a devastating condition providing more than 99% of patients for surgical treatment. We hypothesized that rectovaginal fistula may be healed by therapy with stable gastric pentadecapeptide BPC 157, in consistence with its initial clinical application and effect on external fistulas.BPC 157 (10μg/kg or 10ng/kg) was given perorally,
Barić, Marko, Zenko Sever, Anita, Batelja Vuletić, Lovorka, Rašić, Žarko, Sever, Marko, Drmić, Domagoj, Pavelić-Turudić, Tatjana, Sučić, Mario, Vrčić, Hrvoje, Seiwerth, Sven, Sikirić, Predrag   +10 more
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Pentadecapeptide BPC 157 and head injury

2004
Pentadecapeptide BPC 157 and head ...
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