Results 71 to 80 of about 129,200 (329)

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capability.

PLoS Pathogens, 2020
The obligate intracellular parasite Toxoplasma gondii is auxotrophic for several key metabolites and must scavenge these from the host. It is unclear how T.
William J Olson, Bruno Martorelli Di Genova, Gina Gallego-Lopez, Anthony R Dawson, David Stevenson, Daniel Amador-Noguez, Laura J Knoll   +6 more
doaj   +1 more source

Conversion of pentoses by yeasts [PDF]

Biotechnology and Bioengineering, 1983
AbstractThe utilization and conversion of D‐xylose, D‐xylulose, L‐arabinose, and xylitol by yeast strains have been investigated with the following results: (1) The majority of yeasts tested utilize D‐xylose and produce polyols, ethanol, and organic acids. The type and amount of products formed varies with the yeast strains used.
C S, Gong, T A, Claypool, L D, McCracken, C M, Maun, P P, Ueng, G T, Tsao   +5 more
openaire   +2 more sources

Unusual Metabolism and Hypervariation in the Genome of a Gracilibacterium (BD1-5) from an Oil-Degrading Community. [PDF]

, 2019
The candidate phyla radiation (CPR) comprises a large monophyletic group of bacterial lineages known almost exclusively based on genomes obtained using cultivation-independent methods.
Andersen, Gary L, Banfield, Jillian F, Castelle, Cindy J, Hu, Ping, Paul, Blair G, Sieber, Christian MK, Tringe, Susannah G, Valentine, David L   +7 more
core   +2 more sources

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Cell Reports, 2018
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated.
J. Baardman, S. Verberk, K. Prange, M. van Weeghel, Saskia van der Velden, D. Ryan, R. C. Wüst, A. Neele, D. Speijer, S. Denis, M. Witte, R. Houtkooper, L. O’Neill, Elena V. Knatko, A. Dinkova-Kostova, E. Lutgens, M. D. de Winther, J. van den Bossche   +17 more
semanticscholar   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Glucose-6-phosphate-dehydrogenase deficiency as a risk factor in proliferative disorder development [PDF]

, 2009
Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP) which provides reducing power (NADPH) and pentose phosphates.
Alessandra Pani, Antonella Mandas, Claudia Abete, Claudia Norfo, Enrico Peiretti, Fabrizio Angius, Giacomo Diaz, Maurizio Fossarello, Pierluigi Cocco, Sandra Dessì   +9 more
core   +1 more source

Genome-scale consequences of cofactor balancing in engineered pentose utilization pathways in Saccharomyces cerevisiae. [PDF]

PLoS ONE, 2011
Biofuels derived from lignocellulosic biomass offer promising alternative renewable energy sources for transportation fuels. Significant effort has been made to engineer Saccharomyces cerevisiae to efficiently ferment pentose sugars such as D-xylose and ...
Amit Ghosh, Huimin Zhao, Nathan D Price
doaj   +1 more source