Results 161 to 170 of about 6,209 (222)

Pentylenetetrazol kindling in mice

Neuropharmacology, 1989
Kindling with pentylenetetrazol to produce minimal and maximal convulsions was investigated in CF-1 mice. Like electrical kindling, the kindling effect was directly proportional to the dose or the intensity of the kindling stimulus. Similarly, the kindling effect was persistent, as was emphasized by the ability to kindle with an interdose interval of 3
R, Karler, V, Murphy, L D, Calder, S A, Turkanis   +3 more
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Pentylenetetrazol (Metrazol) in Mental Deficiency

Archives of Pediatrics & Adolescent Medicine, 1957
Introduction Pentylenetetrazol (Metrazol) has been used as a respiratory stimulant for 30 years and as a convulsant for 20 years. The pharmacology and chemistry of the drug was described in 1937 by Giessen, 1 who gave a bibliography of the German literature up to that time.
H H, BERMAN, M, LAZAR, O, NOE, H, SCHILLER   +3 more
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Analysis of the convulsant action of pentylenetetrazol

Experientia, 1969
Les effets du pentylenetetrazol sur la transmission de l'influx nerveux dans le noyau de Burdach furent etudies. Il apparut que ce produit empeche l'augmentation de l'excitabilite des extremites afferentes cuneaires et l'inhibition de la reaction lemnisque, ceci en conditionnant les decharges cutanees. Le pentylenetetrazol reduit aussi l'intensite de l'
N R, Banna, J, Hazbun
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Evaluation of the anticonvulsant activity of the essential oil of Myrothamnus moschatus in convulsion induced by pentylenetetrazole and picrotoxin [PDF]

Asian Pacific Journal of Tropical Biomedicine, 2016
Objective: To evaluate the anticonvulsant effect of the essential oil of Myrothamnus moschatus (M. moschatus) in convulsion induced by pentylenetetrazole and picrotoxin in rodent models. Methods: The essential oil of the aerial parts of M. moschatus was
Filippo Maggi, Marcello Nicoletti, Philippe Rasoanaivo   +2 more
exaly   +2 more sources

Pentylenetetrazol and Renshaw cell activity

International Journal of Neuropharmacology, 1969
Summary The evoked and spontaneous activity of Renshaw cells in unanesthetized spinal cats was studied with metal microelectrodes before and after pentylenetetrazol (40 mg/kg). The drug did not prolong the discharge of Renshaw cells following dorsal root or ventral root stimulation. In addition, several cells were examined for the effects of the drug
H K, Borys, D W, Esplin
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Pentylenetetrazol (Metrazol) Activation of the Electroencephalogram

Archives of Neurology And Psychiatry, 1956
The purpose of this study is to evaluate one of the methods of pentylenetetrazol (Metrazol) activation of the EEG in clinical and control groups in order to gain further information regarding the validity of such a procedure as an adjunct to the diagnosis of seizure states.
H H, SCHWAMB, R E, CLAUSEN, J W, SUMNER
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Pentylenetetrazol Enhances Memory Function

Science, 1966
Pentylenetetrazol, in oral doses of 1 to 30 milligrams per kilogram of body weight, significantly facilitated one-trial learning and memory retention in CF1 mice, whether administered before or immediately after the initial trial. The effects appeared significantly greater than those observed in earlier studies with oral administration of strychnine or
S, Irwin, A, Benuazizi
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Pentylenetetrazole: A review

Neurochemistry International
Pentylenetetrazole (PTZ), a tetrazole derivative, is commonly used as a chemical agent to induce neurological disorders and replicate the characteristics of human epileptic seizures in animal models. This review offers a comprehensive analysis of the behavioral, neurophysiological, and neurochemical changes induced by PTZ.
Álefe Brito, Monteiro, Alan Ferreira, Alves, Anne Caroline, Ribeiro Portela, Hugo Fernandes, Oliveira Pires, Mayara, Pessoa de Melo, Nayana Maria, Medeiros Vilar Barbosa, Cícero Francisco, Bezerra Felipe   +6 more
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Quantitative Reaction for Pentylenetetrazole

Journal of Pharmaceutical Sciences, 1965
The published procedures for pentylenetetetrazole include either a gravimetric determination or a filtration step. The method described allows direct titration with hydrochloric acid following precipitation of a silver-pentylenetetrazole phosphotungstate salt.
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Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice.

The Journal of Pharmacology and Experimental Therapeutics, 1980
Pentylenetetrazol (PTZ) is often used in experimental models of epilepsy. The relationship of the PTZ-induced seizure sequence of myoclonus, clonus and hindlimb extension (TE) to brain PTZ levels has not been reported. This study examined this relationship and determined how different routes of PTZ administration affected brain PTZ uptake and seizure ...
W D, Yonekawa, H J, Kupferberg, D M, Woodbury   +2 more
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