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Pentylenetetrazol kindling in mice

Neuropharmacology, 1989
Kindling with pentylenetetrazol to produce minimal and maximal convulsions was investigated in CF-1 mice. Like electrical kindling, the kindling effect was directly proportional to the dose or the intensity of the kindling stimulus. Similarly, the kindling effect was persistent, as was emphasized by the ability to kindle with an interdose interval of 3
R, Karler   +3 more
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Pentylenetetrazol (Metrazol) in Mental Deficiency

Archives of Pediatrics & Adolescent Medicine, 1957
Introduction Pentylenetetrazol (Metrazol) has been used as a respiratory stimulant for 30 years and as a convulsant for 20 years. The pharmacology and chemistry of the drug was described in 1937 by Giessen, 1 who gave a bibliography of the German literature up to that time.
H H, BERMAN   +3 more
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Analysis of the convulsant action of pentylenetetrazol

Experientia, 1969
Les effets du pentylenetetrazol sur la transmission de l'influx nerveux dans le noyau de Burdach furent etudies. Il apparut que ce produit empeche l'augmentation de l'excitabilite des extremites afferentes cuneaires et l'inhibition de la reaction lemnisque, ceci en conditionnant les decharges cutanees. Le pentylenetetrazol reduit aussi l'intensite de l'
N R, Banna, J, Hazbun
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Pentylenetetrazol (Metrazol) Activation of the Electroencephalogram

Archives of Neurology And Psychiatry, 1956
The purpose of this study is to evaluate one of the methods of pentylenetetrazol (Metrazol) activation of the EEG in clinical and control groups in order to gain further information regarding the validity of such a procedure as an adjunct to the diagnosis of seizure states.
H H, SCHWAMB, R E, CLAUSEN, J W, SUMNER
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Pentylenetetrazol Enhances Memory Function

Science, 1966
Pentylenetetrazol, in oral doses of 1 to 30 milligrams per kilogram of body weight, significantly facilitated one-trial learning and memory retention in CF1 mice, whether administered before or immediately after the initial trial. The effects appeared significantly greater than those observed in earlier studies with oral administration of strychnine or
S, Irwin, A, Benuazizi
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