Results 161 to 170 of about 7,019 (224)

The Effects of Pentylenetetrazole and Methylphenoxypropane on Discrimination Learning

Psychopharmacology, 1966
Pretrial injections of pentylenetetrazole had two major effects on discrimination learning: they slowed the speed of response, whether running down an alley or bar pressing in a Skinner box, and at the same time enhanced the ability to learn both successive and simultaneous discriminations.
Earl Hunt
exaly   +3 more sources

Acute Administration of Ethanol Suppresses Pentylenetetrazole-Induced c-Fos Expression in Rat Brain

Neuroscience Letters, 1990
The effect of acute ethanol administration on pentylenetetrazole-induced c-fos expression in rat brain was studied. Pentylenetetrazole induced the rapid and transient expression of c-fos mRNA in rat brain.
David A Hume
exaly   +2 more sources

Pentylenetetrazol kindling in mice

Neuropharmacology, 1989
Kindling with pentylenetetrazol to produce minimal and maximal convulsions was investigated in CF-1 mice. Like electrical kindling, the kindling effect was directly proportional to the dose or the intensity of the kindling stimulus. Similarly, the kindling effect was persistent, as was emphasized by the ability to kindle with an interdose interval of 3
R, Karler, V, Murphy, L D, Calder, S A, Turkanis   +3 more
openaire   +2 more sources

Pentylenetetrazol Enhances Memory Function

Science, 1966
Pentylenetetrazol, in oral doses of 1 to 30 milligrams per kilogram of body weight, significantly facilitated one-trial learning and memory retention in CF1 mice, whether administered before or immediately after the initial trial. The effects appeared significantly greater than those observed in earlier studies with oral administration of strychnine or
S, Irwin, A, Benuazizi
openaire   +2 more sources

Pentylenetetrazol (Metrazol) in Mental Deficiency

Archives of Pediatrics & Adolescent Medicine, 1957
Introduction Pentylenetetrazol (Metrazol) has been used as a respiratory stimulant for 30 years and as a convulsant for 20 years. The pharmacology and chemistry of the drug was described in 1937 by Giessen, 1 who gave a bibliography of the German literature up to that time.
H H, BERMAN, M, LAZAR, O, NOE, H, SCHILLER   +3 more
openaire   +2 more sources

Pentylenetetrazol (Metrazol) Activation of the Electroencephalogram

Archives of Neurology And Psychiatry, 1956
The purpose of this study is to evaluate one of the methods of pentylenetetrazol (Metrazol) activation of the EEG in clinical and control groups in order to gain further information regarding the validity of such a procedure as an adjunct to the diagnosis of seizure states.
H H, SCHWAMB, R E, CLAUSEN, J W, SUMNER
openaire   +2 more sources

Analysis of the convulsant action of pentylenetetrazol

Experientia, 1969
Les effets du pentylenetetrazol sur la transmission de l'influx nerveux dans le noyau de Burdach furent etudies. Il apparut que ce produit empeche l'augmentation de l'excitabilite des extremites afferentes cuneaires et l'inhibition de la reaction lemnisque, ceci en conditionnant les decharges cutanees. Le pentylenetetrazol reduit aussi l'intensite de l'
N R, Banna, J, Hazbun
openaire   +2 more sources

Pentylenetetrazole: A review

Neurochemistry International
Pentylenetetrazole (PTZ), a tetrazole derivative, is commonly used as a chemical agent to induce neurological disorders and replicate the characteristics of human epileptic seizures in animal models. This review offers a comprehensive analysis of the behavioral, neurophysiological, and neurochemical changes induced by PTZ.
Álefe Brito, Monteiro, Alan Ferreira, Alves, Anne Caroline, Ribeiro Portela, Hugo Fernandes, Oliveira Pires, Mayara, Pessoa de Melo, Nayana Maria, Medeiros Vilar Barbosa, Cícero Francisco, Bezerra Felipe   +6 more
openaire   +2 more sources

Quantitative Reaction for Pentylenetetrazole

Journal of Pharmaceutical Sciences, 1965
The published procedures for pentylenetetetrazole include either a gravimetric determination or a filtration step. The method described allows direct titration with hydrochloric acid following precipitation of a silver-pentylenetetrazole phosphotungstate salt.
openaire   +2 more sources