Results 181 to 190 of about 6,209 (222)

Traxoprodil decreases pentylenetetrazol-induced seizures

Epilepsy Research, 2012
Polyamines, including spermidine, facilitate seizures by positively modulating N-methyl-d-aspartate receptors (NMDAr). Although NMDAr antagonists decrease seizures, it remains to be determined whether traxoprodil, a selective antagonist at the NR2B subunit of the NMDAr, decreases seizures and whether spermidine facilitates pentylenetetrazol (PTZ ...
Ana Paula, Naspolini, Ariane Rubin, Cocco, Felipe, Villa Martignoni, Mauro Schneider, Oliveira, Ana Flávia, Furian, Leonardo Magno, Rambo, Maribel Antonello, Rubin, Susan, Barron, Carlos Fernando, Mello   +8 more
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Transfer of pentylenetetrazol sensitization to amygdaloid kindling

Pharmacology Biochemistry and Behavior, 1981
Rats repeatedly injected with initially subconvulsive doses of pentylenetetrazol (PTZ) eventually became sensitized to the drug (displayed twitching and myoclonic jerks). Other rats injected with increased doses of PTZ displayed both sensitization and generalized convulsions.
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Disruption of taste aversion learning by pentylenetetrazol

Psychopharmacology, 1979
Rats were taught an aversion to a sucrose taste cue (CS) by pairing it with lithium chloride-induced toxicosis (UCS). The CS-UCS interval was 30 min. Animals were injected with pentylenetetrazol (PTZ) (50 mg/kg at 0, 15, 25, 28 or 30 min after the CS in an attempt to disrupt taste aversion learning.
N, Shaw, D M, Webster
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The Effect of Pain on Pentylenetetrazol Induced Seizures

International Journal of Neuroscience, 1991
Repeated administrations of subconvulsive doses of pentylenetetrazol (PTZ) leads to frank convulsions. The number of injections required to bring about such an effect is taken as an index of seizure vulnerability, and was studied in normal rats. This study examined the effect of pain induced by formaline injection or placement on a hot plate on seizure
S, Yehuda, R L, Carasso, D I, Mostofsky
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Effects of pentylenetetrazol on memory storage in mice

Psychopharmacologia, 1968
This paper reports several studies of the effects of pentylenetetrazol on learning in mice. The first three studies indicated that, for several strains and learning tasks, the degree of facilitation produced by posttrial injections of subconvulsive doses of pentylenetetrazol varied with the different strains and experimental conditions used. The fourth
Krivanek, J, Mcgaugh, J L
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Pentylenetetrazole affects metabolism of astrocytes in culture

Journal of Neuroscience Research, 2004
AbstractCortical and cerebellar astrocytes were cultured in medium containing pentylenetetrazole (PTZ), a γ‐aminobutyric acid (GABA)A receptor antagonist, for 3 weeks (up to 6 mM) or 2 hr (10 mM). Cells were incubated in medium containing [U‐13C]glutamate (0.5 mM) and unlabeled glucose (3 mM) for 2 hr and cell extracts and media were analyzed by 13C ...
Hong, Qu, Haytham, Eloqayli, Ursula, Sonnewald   +2 more
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A study of pentylenetetrazol kindling in rats and mice

Pharmacology Biochemistry and Behavior, 1988
The effect of repeated injection of pentylenetetrazol on pentylenetetrazol seizure thresholds was determined in mice and rats. Once per week treatment of rats with pentylenetetrazol resulted in the development of a state of kindling. On the other hand, when pentylenetetrazol was administered twice per week, a phenomenon resembling tolerance was ...
C R, Craig, B K, Colasanti
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Thalidomide inhibits pentylenetetrazole-induced seizures

Journal of the Neurological Sciences, 2007
Thalidomide was originally synthesized and tested as a sedative, hypnotic and antiemetic; however, after its teratogenicity was noted its use for treatment of neurological and psychiatric disorders was abandoned. We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg ...
Guadalupe, Palencia, Alejandra, Calderon, Julio, Sotelo   +2 more
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Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol — induced seizures

Epilepsy Research, 2001
The aim of our study was to investigate amino acid and energy metabolism of pentylenetetrazol (PTZ)-kindled animals. Glutamate dehydrogenase, aspartate-aminotransferase (AST), alanine-aminotransferase, gamma-glutamyltransferase, alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) were determined in the frontal cortex ...
Eraković, Vesna, Župan, Gordana, Varljen, Jadranka, Laginja, Josip, Simonić, Ante   +4 more
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Nitric Oxide (NO) and Convulsions Induced by Pentylenetetrazol

Annals of the New York Academy of Sciences, 2002
Abstract: Data about the role of nitric oxide (NO) in epileptogenesis are contradictory. It is found to exert both proconvulsant and anticonvulsant effects. In an attempt to elucidate the role of NO in seizures, male Wistar rats were treated intraperitoneally by pentylenetetrazol (PTZ) (60, 80, and 100 mg/kg) and by a nitric oxide synthase antagonist,
Ankica, Jelenković, Marina, Jovanović, Milica, Ninković, M, Maksimović, D, Bokonjić, B, Bosković   +5 more
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