Results 181 to 190 of about 7,019 (224)

The Effect of Pain on Pentylenetetrazol Induced Seizures

International Journal of Neuroscience, 1991
Repeated administrations of subconvulsive doses of pentylenetetrazol (PTZ) leads to frank convulsions. The number of injections required to bring about such an effect is taken as an index of seizure vulnerability, and was studied in normal rats. This study examined the effect of pain induced by formaline injection or placement on a hot plate on seizure
S, Yehuda, R L, Carasso, D I, Mostofsky
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Facilitation of learning by delayed injections of pentylenetetrazol

Psychopharmacologia, 1969
In the first experiment rats were trained in black-white discrimination, then injected with 7.5, 10.0, or 15.0 mg/kg of pentylenetetrazol (Metrazol) or saline. Injections were given immediately or 15 min following training. The animals were retested 24 hours later.
E B, Hunt, R H, Bauer
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The site of action for the convulsant effect of pentylenetetrazol

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1981
Abstract 1. Lymnaea neutons demonstrated convulsive bursting in response to 40 mM pentylenetetrazol (PTZ) applied extracellularly but showed no response to injections calculated to bring intracellular concentrations of PTZ to 100 mM. 2. PTZ was found to permeate cell membranes. 3.
M F, Pacheco, J C, Fowler, L D, Partridge   +2 more
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Vigabatrin as an Anticonvulsant Against Pentylenetetrazol Seizures

Pharmacological Research, 1993
The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective.
U, Sayin, S, Cengiz, T, Altug
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Improvements in the Synthesis of Pentylenetetrazol-10-14C

Journal of Pharmaceutical Sciences, 1974
Improvements in the synthesis of pentylenetetrazol-10-14C from hydrazoic acid and cyclohexanone-1-14C are reported. Purification was accomplished by crystallization. Chemical purity was determined by GLC and TLC. The radiochemical purity was determined by TLC and autoradiography. The specific activity was found by liquid scintillation counting.
J W, Dirksen, G S, Born, W V, Kessler, S M, Shaw   +3 more
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Pentylenetetrazole affects metabolism of astrocytes in culture

Journal of Neuroscience Research, 2004
AbstractCortical and cerebellar astrocytes were cultured in medium containing pentylenetetrazole (PTZ), a γ‐aminobutyric acid (GABA)A receptor antagonist, for 3 weeks (up to 6 mM) or 2 hr (10 mM). Cells were incubated in medium containing [U‐13C]glutamate (0.5 mM) and unlabeled glucose (3 mM) for 2 hr and cell extracts and media were analyzed by 13C ...
Hong, Qu, Haytham, Eloqayli, Ursula, Sonnewald   +2 more
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Transfer of pentylenetetrazol sensitization to amygdaloid kindling

Pharmacology Biochemistry and Behavior, 1981
Rats repeatedly injected with initially subconvulsive doses of pentylenetetrazol (PTZ) eventually became sensitized to the drug (displayed twitching and myoclonic jerks). Other rats injected with increased doses of PTZ displayed both sensitization and generalized convulsions.
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Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol — induced seizures

Epilepsy Research, 2001
The aim of our study was to investigate amino acid and energy metabolism of pentylenetetrazol (PTZ)-kindled animals. Glutamate dehydrogenase, aspartate-aminotransferase (AST), alanine-aminotransferase, gamma-glutamyltransferase, alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) were determined in the frontal cortex ...
Eraković, Vesna, Župan, Gordana, Varljen, Jadranka, Laginja, Josip, Simonić, Ante   +4 more
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Effects of tybamate and pentylenetetrazol on spinal interneurons

Experientia, 1972
Das Muskelrelaxans Tybamat ruft eine Hemmung der Aktivitat spinaler Interneurone hervor, die von einer Blockade des spinalen polysynaptischen Reflexes begleitet ist. Pentylenetetrazol hingegen hebt die beiden durch Tybamat erzeugten Effekte auf, steigert zudem die interneuronale Aktivitat, eine Eigenschaft, die die Verstarkung des polysynaptischen ...
E B, Kirsten, T C, Tseng
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Traxoprodil decreases pentylenetetrazol-induced seizures

Epilepsy Research, 2012
Polyamines, including spermidine, facilitate seizures by positively modulating N-methyl-d-aspartate receptors (NMDAr). Although NMDAr antagonists decrease seizures, it remains to be determined whether traxoprodil, a selective antagonist at the NR2B subunit of the NMDAr, decreases seizures and whether spermidine facilitates pentylenetetrazol (PTZ ...
Ana Paula, Naspolini, Ariane Rubin, Cocco, Felipe, Villa Martignoni, Mauro Schneider, Oliveira, Ana Flávia, Furian, Leonardo Magno, Rambo, Maribel Antonello, Rubin, Susan, Barron, Carlos Fernando, Mello   +8 more
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