Results 181 to 190 of about 9,677 (229)

Facilitation of learning by delayed injections of pentylenetetrazol

Psychopharmacologia, 1969
In the first experiment rats were trained in black-white discrimination, then injected with 7.5, 10.0, or 15.0 mg/kg of pentylenetetrazol (Metrazol) or saline. Injections were given immediately or 15 min following training. The animals were retested 24 hours later.
E B, Hunt, R H, Bauer
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Effects of tybamate and pentylenetetrazol on spinal interneurons

Experientia, 1972
Das Muskelrelaxans Tybamat ruft eine Hemmung der Aktivitat spinaler Interneurone hervor, die von einer Blockade des spinalen polysynaptischen Reflexes begleitet ist. Pentylenetetrazol hingegen hebt die beiden durch Tybamat erzeugten Effekte auf, steigert zudem die interneuronale Aktivitat, eine Eigenschaft, die die Verstarkung des polysynaptischen ...
E B, Kirsten, T C, Tseng
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Stimulation of cyclic AMP accumulation by pentylenetetrazol

Experimental Neurology, 1976
Abstract The convulsant agent, pentylenetetrazol (PTZ), increased the content of cyclic AMP (cAMP) in rat cortical slices incubated in vitro in physiologic media. This increase was partially reversed by theophylline. The addition of PTZ to maximally effective concentrations of either adenosine or 2-chloroadeosine resulted in a significantly greater
E, Lewin, T, Golden, J E, Walker
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The effects of pentylenetetrazole and methylphenoxypropane on discrimination learning

Psychopharmacologia, 1966
Pretrial injections of pentylenetetrazole had two major effects on discrimination learning: they slowed the speed of response, whether running down an alley or bar pressing in a Skinner box, and at the same time enhanced the ability to learn both successive and simultaneous discriminations.
E, Hunt, J, Krivanek
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Traxoprodil decreases pentylenetetrazol-induced seizures

Epilepsy Research, 2012
Polyamines, including spermidine, facilitate seizures by positively modulating N-methyl-d-aspartate receptors (NMDAr). Although NMDAr antagonists decrease seizures, it remains to be determined whether traxoprodil, a selective antagonist at the NR2B subunit of the NMDAr, decreases seizures and whether spermidine facilitates pentylenetetrazol (PTZ ...
Ana Paula, Naspolini, Ariane Rubin, Cocco, Felipe, Villa Martignoni, Mauro Schneider, Oliveira, Ana Flávia, Furian, Leonardo Magno, Rambo, Maribel Antonello, Rubin, Susan, Barron, Carlos Fernando, Mello   +8 more
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Transfer of pentylenetetrazol sensitization to amygdaloid kindling

Pharmacology Biochemistry and Behavior, 1981
Rats repeatedly injected with initially subconvulsive doses of pentylenetetrazol (PTZ) eventually became sensitized to the drug (displayed twitching and myoclonic jerks). Other rats injected with increased doses of PTZ displayed both sensitization and generalized convulsions.
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Disruption of taste aversion learning by pentylenetetrazol

Psychopharmacology, 1979
Rats were taught an aversion to a sucrose taste cue (CS) by pairing it with lithium chloride-induced toxicosis (UCS). The CS-UCS interval was 30 min. Animals were injected with pentylenetetrazol (PTZ) (50 mg/kg at 0, 15, 25, 28 or 30 min after the CS in an attempt to disrupt taste aversion learning.
N, Shaw, D M, Webster
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The Effect of Pain on Pentylenetetrazol Induced Seizures

International Journal of Neuroscience, 1991
Repeated administrations of subconvulsive doses of pentylenetetrazol (PTZ) leads to frank convulsions. The number of injections required to bring about such an effect is taken as an index of seizure vulnerability, and was studied in normal rats. This study examined the effect of pain induced by formaline injection or placement on a hot plate on seizure
S, Yehuda, R L, Carasso, D I, Mostofsky
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Effects of pentylenetetrazol on memory storage in mice

Psychopharmacologia, 1968
This paper reports several studies of the effects of pentylenetetrazol on learning in mice. The first three studies indicated that, for several strains and learning tasks, the degree of facilitation produced by posttrial injections of subconvulsive doses of pentylenetetrazol varied with the different strains and experimental conditions used. The fourth
Krivanek, J, Mcgaugh, J L
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Pentylenetetrazole affects metabolism of astrocytes in culture

Journal of Neuroscience Research, 2004
AbstractCortical and cerebellar astrocytes were cultured in medium containing pentylenetetrazole (PTZ), a γ‐aminobutyric acid (GABA)A receptor antagonist, for 3 weeks (up to 6 mM) or 2 hr (10 mM). Cells were incubated in medium containing [U‐13C]glutamate (0.5 mM) and unlabeled glucose (3 mM) for 2 hr and cell extracts and media were analyzed by 13C ...
Hong, Qu, Haytham, Eloqayli, Ursula, Sonnewald   +2 more
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