Results 171 to 180 of about 7,019 (224)

Pentylenetetrazol and Renshaw cell activity

International Journal of Neuropharmacology, 1969
Summary The evoked and spontaneous activity of Renshaw cells in unanesthetized spinal cats was studied with metal microelectrodes before and after pentylenetetrazol (40 mg/kg). The drug did not prolong the discharge of Renshaw cells following dorsal root or ventral root stimulation. In addition, several cells were examined for the effects of the drug
H K, Borys, D W, Esplin
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Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice.

The Journal of Pharmacology and Experimental Therapeutics, 1980
Pentylenetetrazol (PTZ) is often used in experimental models of epilepsy. The relationship of the PTZ-induced seizure sequence of myoclonus, clonus and hindlimb extension (TE) to brain PTZ levels has not been reported. This study examined this relationship and determined how different routes of PTZ administration affected brain PTZ uptake and seizure ...
W D, Yonekawa, H J, Kupferberg, D M, Woodbury   +2 more
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A study of pentylenetetrazol kindling in rats and mice

Pharmacology Biochemistry and Behavior, 1988
The effect of repeated injection of pentylenetetrazol on pentylenetetrazol seizure thresholds was determined in mice and rats. Once per week treatment of rats with pentylenetetrazol resulted in the development of a state of kindling. On the other hand, when pentylenetetrazol was administered twice per week, a phenomenon resembling tolerance was ...
C R, Craig, B K, Colasanti
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Thalidomide inhibits pentylenetetrazole-induced seizures

Journal of the Neurological Sciences, 2007
Thalidomide was originally synthesized and tested as a sedative, hypnotic and antiemetic; however, after its teratogenicity was noted its use for treatment of neurological and psychiatric disorders was abandoned. We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg ...
Guadalupe, Palencia, Alejandra, Calderon, Julio, Sotelo   +2 more
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Stimulation of cyclic AMP accumulation by pentylenetetrazol

Experimental Neurology, 1976
Abstract The convulsant agent, pentylenetetrazol (PTZ), increased the content of cyclic AMP (cAMP) in rat cortical slices incubated in vitro in physiologic media. This increase was partially reversed by theophylline. The addition of PTZ to maximally effective concentrations of either adenosine or 2-chloroadeosine resulted in a significantly greater
E, Lewin, T, Golden, J E, Walker
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Effect of cocaine and pentylenetetrazol on cortical kindling

Pharmacology Biochemistry and Behavior, 1985
The effect of drug-induced convulsions on subsequent cortical kindling was studied in male Long-Evans rats. Animals experienced three intravenous infusions of physiological saline at 3 day intervals, or three convulsions induced by the infusion of cocaine or pentylenetetrazol (PTZ). Beginning eight days after the last infusion, all animals were kindled
J S, Stripling, R D, Russell
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Determination of Pentylenetetrazol in Tablets and Injectables by NMR

Journal of Pharmaceutical Sciences, 1972
A rapid and accurate NMR procedure is described for the analysis of pentylenetetrazol in tablet and injection dosage forms. A standard deviation of 0.7% was obtained on 10 synthetic mixtures. The NMR spectrum, in addition, provides a very specific means of identification for pentylenetetrazol.
J W, Turczan, B A, Goldwitz
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GLC Determination of Pentylenetetrazol in Biological Fluids

Journal of Pharmaceutical Sciences, 1972
A rapid and sensitive GLC method for the determination of pentylenetetrazol was developed. The lower limit of detection is 1 ng./μl. of pentylenetetrazol. The technique involves extraction of drug from water, plasma, urine, and/or whole blood into organic solvent, evaporation of the solvent phase to dryness, and redissolving in water.
J T, Stewart, J L, Story
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Pentylenetetrazol Effect on Adrenocortical Maturation in the Rat

Hormone Research, 2008
The effect of pentylenetetrazol on adrenal cortex maturation was investigated. Two different groups of weanling Sprague-Dawley female rats were used. At the ages of 23 and 29 days, the animals were treated with pentylenetetrazol (10 mg/kg) for 3 days.
A D, Okonmah, K F, Soliman
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Pharmacokinetic Studies of Pentylenetetrazol in Dogs

Journal of Pharmaceutical Sciences, 1976
Pharmacokinetic profiles of pentylenetetrazol in the dog were studied following rapid intravenous and oral administrations of a convulsant dose (15-20 mg/kg). Plasma level-time curves after a rapid intravenous injection showed biexponential decline, indicating that the disposition of this drug in the dog follows a two-compartment body model ...
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