Results 171 to 180 of about 9,677 (229)

Pentylenetetrazol and Renshaw cell activity

International Journal of Neuropharmacology, 1969
Summary The evoked and spontaneous activity of Renshaw cells in unanesthetized spinal cats was studied with metal microelectrodes before and after pentylenetetrazol (40 mg/kg). The drug did not prolong the discharge of Renshaw cells following dorsal root or ventral root stimulation. In addition, several cells were examined for the effects of the drug
H K, Borys, D W, Esplin
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Pentylenetetrazole: A review

Neurochemistry International
Pentylenetetrazole (PTZ), a tetrazole derivative, is commonly used as a chemical agent to induce neurological disorders and replicate the characteristics of human epileptic seizures in animal models. This review offers a comprehensive analysis of the behavioral, neurophysiological, and neurochemical changes induced by PTZ.
Álefe Brito, Monteiro, Alan Ferreira, Alves, Anne Caroline, Ribeiro Portela, Hugo Fernandes, Oliveira Pires, Mayara, Pessoa de Melo, Nayana Maria, Medeiros Vilar Barbosa, Cícero Francisco, Bezerra Felipe   +6 more
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Quantitative Reaction for Pentylenetetrazole

Journal of Pharmaceutical Sciences, 1965
The published procedures for pentylenetetetrazole include either a gravimetric determination or a filtration step. The method described allows direct titration with hydrochloric acid following precipitation of a silver-pentylenetetrazole phosphotungstate salt.
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Relationship between pentylenetetrazol-induced seizures and brain pentylenetetrazol levels in mice.

The Journal of Pharmacology and Experimental Therapeutics, 1980
Pentylenetetrazol (PTZ) is often used in experimental models of epilepsy. The relationship of the PTZ-induced seizure sequence of myoclonus, clonus and hindlimb extension (TE) to brain PTZ levels has not been reported. This study examined this relationship and determined how different routes of PTZ administration affected brain PTZ uptake and seizure ...
W D, Yonekawa, H J, Kupferberg, D M, Woodbury   +2 more
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The site of action for the convulsant effect of pentylenetetrazol

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1981
Abstract 1. Lymnaea neutons demonstrated convulsive bursting in response to 40 mM pentylenetetrazol (PTZ) applied extracellularly but showed no response to injections calculated to bring intracellular concentrations of PTZ to 100 mM. 2. PTZ was found to permeate cell membranes. 3.
M F, Pacheco, J C, Fowler, L D, Partridge   +2 more
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Effect of cocaine and pentylenetetrazol on cortical kindling

Pharmacology Biochemistry and Behavior, 1985
The effect of drug-induced convulsions on subsequent cortical kindling was studied in male Long-Evans rats. Animals experienced three intravenous infusions of physiological saline at 3 day intervals, or three convulsions induced by the infusion of cocaine or pentylenetetrazol (PTZ). Beginning eight days after the last infusion, all animals were kindled
J S, Stripling, R D, Russell
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GLC Determination of Pentylenetetrazol in Biological Fluids

Journal of Pharmaceutical Sciences, 1972
A rapid and sensitive GLC method for the determination of pentylenetetrazol was developed. The lower limit of detection is 1 ng./μl. of pentylenetetrazol. The technique involves extraction of drug from water, plasma, urine, and/or whole blood into organic solvent, evaporation of the solvent phase to dryness, and redissolving in water.
J T, Stewart, J L, Story
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Vigabatrin as an Anticonvulsant Against Pentylenetetrazol Seizures

Pharmacological Research, 1993
The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective.
U, Sayin, S, Cengiz, T, Altug
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Improvements in the Synthesis of Pentylenetetrazol-10-14C

Journal of Pharmaceutical Sciences, 1974
Improvements in the synthesis of pentylenetetrazol-10-14C from hydrazoic acid and cyclohexanone-1-14C are reported. Purification was accomplished by crystallization. Chemical purity was determined by GLC and TLC. The radiochemical purity was determined by TLC and autoradiography. The specific activity was found by liquid scintillation counting.
J W, Dirksen, G S, Born, W V, Kessler, S M, Shaw   +3 more
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Pharmacokinetic Studies of Pentylenetetrazol in Dogs

Journal of Pharmaceutical Sciences, 1976
Pharmacokinetic profiles of pentylenetetrazol in the dog were studied following rapid intravenous and oral administrations of a convulsant dose (15-20 mg/kg). Plasma level-time curves after a rapid intravenous injection showed biexponential decline, indicating that the disposition of this drug in the dog follows a two-compartment body model ...
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