Results 171 to 180 of about 6,209 (222)

The site of action for the convulsant effect of pentylenetetrazol

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1981
Abstract 1. Lymnaea neutons demonstrated convulsive bursting in response to 40 mM pentylenetetrazol (PTZ) applied extracellularly but showed no response to injections calculated to bring intracellular concentrations of PTZ to 100 mM. 2. PTZ was found to permeate cell membranes. 3.
M F, Pacheco, J C, Fowler, L D, Partridge   +2 more
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Effect of cocaine and pentylenetetrazol on cortical kindling

Pharmacology Biochemistry and Behavior, 1985
The effect of drug-induced convulsions on subsequent cortical kindling was studied in male Long-Evans rats. Animals experienced three intravenous infusions of physiological saline at 3 day intervals, or three convulsions induced by the infusion of cocaine or pentylenetetrazol (PTZ). Beginning eight days after the last infusion, all animals were kindled
J S, Stripling, R D, Russell
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GLC Determination of Pentylenetetrazol in Biological Fluids

Journal of Pharmaceutical Sciences, 1972
A rapid and sensitive GLC method for the determination of pentylenetetrazol was developed. The lower limit of detection is 1 ng./μl. of pentylenetetrazol. The technique involves extraction of drug from water, plasma, urine, and/or whole blood into organic solvent, evaporation of the solvent phase to dryness, and redissolving in water.
J T, Stewart, J L, Story
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Vigabatrin as an Anticonvulsant Against Pentylenetetrazol Seizures

Pharmacological Research, 1993
The anticonvulsant effects of gamma vinyl GABA (GVG) were investigated against pentylenetetrazol (PTZ) seizures, while sodium valproate (VP) was used as positive control. At 1000 and 1500 mg kg-1 GVG was found to decrease seizure intensity either in 4 or 24 h, as effectively as VP. At 2000 mg kg-1 GVG was found to be almost ineffective.
U, Sayin, S, Cengiz, T, Altug
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Effects of tybamate and pentylenetetrazol on spinal interneurons

Experientia, 1972
Das Muskelrelaxans Tybamat ruft eine Hemmung der Aktivitat spinaler Interneurone hervor, die von einer Blockade des spinalen polysynaptischen Reflexes begleitet ist. Pentylenetetrazol hingegen hebt die beiden durch Tybamat erzeugten Effekte auf, steigert zudem die interneuronale Aktivitat, eine Eigenschaft, die die Verstarkung des polysynaptischen ...
E B, Kirsten, T C, Tseng
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Pharmacokinetic Studies of Pentylenetetrazol in Dogs

Journal of Pharmaceutical Sciences, 1976
Pharmacokinetic profiles of pentylenetetrazol in the dog were studied following rapid intravenous and oral administrations of a convulsant dose (15-20 mg/kg). Plasma level-time curves after a rapid intravenous injection showed biexponential decline, indicating that the disposition of this drug in the dog follows a two-compartment body model ...
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Stimulation of cyclic AMP accumulation by pentylenetetrazol

Experimental Neurology, 1976
Abstract The convulsant agent, pentylenetetrazol (PTZ), increased the content of cyclic AMP (cAMP) in rat cortical slices incubated in vitro in physiologic media. This increase was partially reversed by theophylline. The addition of PTZ to maximally effective concentrations of either adenosine or 2-chloroadeosine resulted in a significantly greater
E, Lewin, T, Golden, J E, Walker
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Improvements in the Synthesis of Pentylenetetrazol-10-14C

Journal of Pharmaceutical Sciences, 1974
Improvements in the synthesis of pentylenetetrazol-10-14C from hydrazoic acid and cyclohexanone-1-14C are reported. Purification was accomplished by crystallization. Chemical purity was determined by GLC and TLC. The radiochemical purity was determined by TLC and autoradiography. The specific activity was found by liquid scintillation counting.
J W, Dirksen, G S, Born, W V, Kessler, S M, Shaw   +3 more
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Facilitation of learning by delayed injections of pentylenetetrazol

Psychopharmacologia, 1969
In the first experiment rats were trained in black-white discrimination, then injected with 7.5, 10.0, or 15.0 mg/kg of pentylenetetrazol (Metrazol) or saline. Injections were given immediately or 15 min following training. The animals were retested 24 hours later.
E B, Hunt, R H, Bauer
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The effects of pentylenetetrazole and methylphenoxypropane on discrimination learning

Psychopharmacologia, 1966
Pretrial injections of pentylenetetrazole had two major effects on discrimination learning: they slowed the speed of response, whether running down an alley or bar pressing in a Skinner box, and at the same time enhanced the ability to learn both successive and simultaneous discriminations.
E, Hunt, J, Krivanek
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