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A study of pentylenetetrazol kindling in rats and mice
Pharmacology Biochemistry and Behavior, 1988The effect of repeated injection of pentylenetetrazol on pentylenetetrazol seizure thresholds was determined in mice and rats. Once per week treatment of rats with pentylenetetrazol resulted in the development of a state of kindling. On the other hand, when pentylenetetrazol was administered twice per week, a phenomenon resembling tolerance was ...
C R, Craig, B K, Colasanti
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Thalidomide inhibits pentylenetetrazole-induced seizures
Journal of the Neurological Sciences, 2007Thalidomide was originally synthesized and tested as a sedative, hypnotic and antiemetic; however, after its teratogenicity was noted its use for treatment of neurological and psychiatric disorders was abandoned. We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg ...
Guadalupe, Palencia +2 more
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Epilepsy Research, 2001
The aim of our study was to investigate amino acid and energy metabolism of pentylenetetrazol (PTZ)-kindled animals. Glutamate dehydrogenase, aspartate-aminotransferase (AST), alanine-aminotransferase, gamma-glutamyltransferase, alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) were determined in the frontal cortex ...
Eraković, Vesna +4 more
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The aim of our study was to investigate amino acid and energy metabolism of pentylenetetrazol (PTZ)-kindled animals. Glutamate dehydrogenase, aspartate-aminotransferase (AST), alanine-aminotransferase, gamma-glutamyltransferase, alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) were determined in the frontal cortex ...
Eraković, Vesna +4 more
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Nitric Oxide (NO) and Convulsions Induced by Pentylenetetrazol
Annals of the New York Academy of Sciences, 2002Abstract: Data about the role of nitric oxide (NO) in epileptogenesis are contradictory. It is found to exert both proconvulsant and anticonvulsant effects. In an attempt to elucidate the role of NO in seizures, male Wistar rats were treated intraperitoneally by pentylenetetrazol (PTZ) (60, 80, and 100 mg/kg) and by a nitric oxide synthase antagonist,
Ankica, Jelenković +5 more
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Photometric Determination of Pentylenetetrazol in Pharmaceutical Preparations
Journal of Pharmaceutical Sciences, 1963Pentylenetetrazol is quantitatively precipitated from aqueous solution by cuprous chloride reagent. The pentylenetetrazol-cuprous chloride complex is dissolved in concentrated nitric acid; the solution is adjusted to pH 4 with acetate buffer and sodium hydroxide solution, and the deep blue color of the copper complex developed with ...
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Determination of Pentylenetetrazol in Tablets and Injectables by NMR
Journal of Pharmaceutical Sciences, 1972A rapid and accurate NMR procedure is described for the analysis of pentylenetetrazol in tablet and injection dosage forms. A standard deviation of 0.7% was obtained on 10 synthetic mixtures. The NMR spectrum, in addition, provides a very specific means of identification for pentylenetetrazol.
J W, Turczan, B A, Goldwitz
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Pentylenetetrazol Effect on Adrenocortical Maturation in the Rat
Hormone Research, 1980The effect of pentylenetetrazol on adrenal cortex maturation was investigated. Two different groups of weanling Sprague-Dawley female rats were used. At the ages of 23 and 29 days, the animals were treated with pentylenetetrazol (10 mg/kg) for 3 days.
A D, Okonmah, K F, Soliman
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Effect of pentylenetetrazol on the leech Retzius cell
Experimental Neurology, 1971Abstract Pentylenetetrazol, 1–10 m m , caused reversible hyperpolarization, cessation of spontaneous firing and fall in input resistance of the Retzius cells of leech segmental ganglia. Transient depolarization and increased firing also occurred in the early portion of the response in some cells.
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The Evaluation of Pentylenetetrazol as a Barbiturate Antagonist.
Anesthesia & Analgesia, 1954J F, FAZEKAS, T, KOPPANYI
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Pentylenetetrazol (PTZ) Kindling Model of Epilepsy
Current Protocols in Neuroscience, 2012AbstractThis unit describes a protocol to perform chemical kindling in mice. Kindling is a chronic animal model of epilepsy that has been extensively studied to understand the process of epileptogenesis and discover novel anti‐epileptic compounds. Kindling is a phenomenon where a sub‐convulsive stimulus (either chemical or electrical), if applied ...
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