Results 101 to 110 of about 200,892 (306)

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

H2S‐Amplified “Three‐in‐One” Antibacterial Strategy for Periodontitis Treatment Using a Photosensitive Pillararene‐Embedded COF/MOF Hybrid

Advanced Science, EarlyView.
The integration of ROS‐generating systems with H2S depletion strategies effectively overcomes the limitations imposed by endogenous antioxidant defenses on ROS‐based antimicrobial therapies. In this study, the Cu‐MOF is incorporated into pillararene‐embedded COF, achieving a “three‐in‐one” antimicrobial effect that markedly alleviated periodontal ...
Shuang Liang, Meng‐Hao Li, Liang Cheng, Tian‐Shou Zhang, Hui Hui, Yan Wang, Hong‐Pu Zhang, Bo‐Wen Liu, Lin Wang, Ying‐Wei Yang   +9 more
wiley   +1 more source

Circular and Leaderless Bacteriocins: Biosynthesis, Mode of Action, Applications, and Prospects

Frontiers in Microbiology, 2018
Bacteriocins are a huge family of ribosomally synthesized peptides known to exhibit a range of bioactivities, most predominantly antibacterial activities.
Rodney H. Perez, Rodney H. Perez, Takeshi Zendo, Kenji Sonomoto   +3 more
doaj   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Current Concepts of the Peptide Antibiotic Gramicidin S Biosynthesis

Антибиотики и Химиотерапия
Gramicidin S is a cyclic decapeptide antibiotic produced by the soil bacterium Aneurinibacillus migulanus (formerly Bacillus brevis, Brevibacillus brevis), one of the first antibiotics ever discovered.
E. R. Mitina, A. B. Pshenichnikova, O. V. Efremenkova   +2 more
doaj   +1 more source

Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis. [PDF]

Nat Commun, 2021
Zhong L, Diao X, Zhang N, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y, Wu D, Bian X.   +10 more
europepmc   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

Leader Peptide and a Membrane Protein Scaffold Guide the Biosynthesis of the Tricyclic Peptide Microviridin [PDF]

, 2011
SummaryMicroviridins are unique protease inhibitors from bloom-forming cyanobacteria that have both ecological and pharmacological relevance. Their peptide backbones are produced ribosomally, and ATP grasp ligases introduce ω-ester and ω-amide bonds to ...
Nadine Ziemert, Annika R. Weiz, Weiz, Annika R., Keishi Ishida, Ishida, Keishi, Dittmann, Elke, Christian Hertweck, Ziemert, Nadine, Hertweck, Christian, Makower, Katharina, Katharina Makower, Dittmann-Thünemann, Elke, Elke Dittmann   +12 more
core   +1 more source

Proinsulin C-peptide-mediated signalling and the search for its receptor [PDF]

, 2017
Proinsulin connecting peptide (C-peptide) joins the A and B-chain of proinsulin and plays an important role in coordinating the folding of insulin. For many years this peptide was simply considered an inert by-product of insulin biosynthesis and was used
Ali Mohsin Hashim Janabi (7716242)
core   +2 more sources

Binase deletion mutant with enhanced cytotoxic properties [PDF]

BIO Web of Conferences
Antitumor peptides are a new class of small molecules characterized by high specificity and therapeutic efficacy. One of the strategies for developing peptide-based therapeutic agents is the modification of the physicochemical properties and structural ...
Dudkina Elena, Kosnyrev Alexander, Ilinskaya Olga, Ulyanova Vera   +3 more
doaj   +1 more source