Results 101 to 110 of about 900,801 (302)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Current Concepts of the Peptide Antibiotic Gramicidin S Biosynthesis

Антибиотики и Химиотерапия
Gramicidin S is a cyclic decapeptide antibiotic produced by the soil bacterium Aneurinibacillus migulanus (formerly Bacillus brevis, Brevibacillus brevis), one of the first antibiotics ever discovered.
E. R. Mitina, A. B. Pshenichnikova, O. V. Efremenkova   +2 more
doaj   +1 more source

Binase deletion mutant with enhanced cytotoxic properties [PDF]

BIO Web of Conferences
Antitumor peptides are a new class of small molecules characterized by high specificity and therapeutic efficacy. One of the strategies for developing peptide-based therapeutic agents is the modification of the physicochemical properties and structural ...
Dudkina Elena, Kosnyrev Alexander, Ilinskaya Olga, Ulyanova Vera   +3 more
doaj   +1 more source

Comparative flux control through the cytoplasmic phase of cell wall biosynthesis [PDF]

The introduction of antibacterial drugs in the middle of the last century heralded a new era in the treatment of infectious disease. However the parallel emergence of antibiotic resistance and decline in new drug discovery threatens these advances. The
Bearup, Daniel James
core  

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Caryophyllaceae cyclic peptide biosynthesis

, 2013
Background: In the Caryophyllaceae, cyclic peptides (CP) are biosynthesized from linear precursors via an unknown pathway. Results: Two protease-like enzymes are involved in precursor processing.
Pujara, Pareshkumar T., Covello, Patrick S., Barber, Carla J. S., Reed, Darwin W., Chiwocha, Shiela, Zhang, Haixia   +5 more
core   +1 more source

Cell wall assembly in Bacillus megaterium: incorporation of new peptidoglycan by a monomer addition process [PDF]

, 1991
The pattern of cross-linking in the peptidoglycan of Bacillus megaterium has been studied by the pulsed addition of radiolabeled diaminopimelic acid.
D L Gally, I C Hancock, C R Harwood, A R Archibald, Harwood, Colin R., Archibald, A.R., Hancock, Ian C., Gally, David   +7 more
core   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

MS

, 2007
thesisSaframycin-like ecteinascidins and patellamides are two groups of cytotoxic marine peptide natural products with potential application as anticancer therapeutics. The biosynthesis of the saframycins occurs through nonribosomal peptide synthesis and
Nelson, James Thomas
core