Results 121 to 130 of about 200,892 (306)

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

HNP-1: From Structure to Application Thanks to Multifaceted Functions

Microorganisms
Antimicrobial peptides (AMPs) are critical components of innate immunity in animals and plants, exhibiting thrilling prospectives as alternatives to traditional antibiotics due to their ability to combat pathogens without leading to resistance.
Jiaqi Zhang, Zhaoke Liu, Zhihao Zhou, Zile Huang, Yifan Yang, Junzhu Wu, Yanhong Liu   +6 more
doaj   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

Ribosomal pentapeptide nitration for non-ribosomal peptide antibiotic precursor biosynthesis [PDF]

Peptide natural products possess a fascinating array of complex structures and diverse biological activities. Central to this is a repertoire of structurally modified amino acid building blocks, which stem from fundamentally different biosynthetic ...
Sasi, Vishnu Mini, Crüsemann, Max, Gullick, Jemma, Zhao, Yongwei, Padva, Leo, Schittenhelm, Ralf B., Zimmer, Lukas, Jackson, Colin J., Cryle, Max J.   +8 more
core   +1 more source

Microblasting Wound Dressings Mechanically Disrupt Polymicrobial Biofilms to Enhance Healing in Treatment‐Resistant Wounds

Advanced Science, EarlyView.
Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn, Joo Hun Lee, Christian Hurd, Jiye Lee, Junggeon Park, Adam A. Markowicz, Zheyuan Zhang, Joanne Hwang, Guillermo L. Monroy, Simon A. Rogers, Woonggyu Jung, Stephen A. Boppart, Hyunjoon Kong   +12 more
wiley   +1 more source

Engineering circular bacteriocins: structural and functional effects of α-helix exchanges and disulfide introductions in circularin A

Frontiers in Microbiology
Circular bacteriocins form a distinct group of antimicrobial peptides (AMPs) characterized by their unique head-to-tail ligated circular structure and functional properties.
Fangfang Liu, Auke J. van Heel, Auke J. van Heel, Oscar P. Kuipers, Oscar P. Kuipers   +4 more
doaj   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Dual roles of SmCLE25 peptide in regulating stresses response and leaf senescence

BMC Plant Biology
Peptide hormones play crucial roles as signaling regulators in plant development and environmental adaptation. This study identified the Salvia miltiorrhiza CLE peptide SmCLE25, which is involved in regulating leaf senescence and multiple stress ...
Wei Zhao, Yuna Sun, Jingjing Li, Yinan Wu, Yangli Tian, Junwei Wei, Yinshuai Tian   +6 more
doaj   +1 more source

Recent advances in synthesis and mining strategies of bioactive peptides in cosmetics

Journal of Dermatologic Science and Cosmetic Technology
Bioactive peptides have emerged as powerful functional ingredients in cosmetics, valued for their rapid action, high specificity, and low toxicity. These short amino acid sequences can deliver antimicrobial, antioxidant, anti-aging, UV-protective, and ...
Chuangen Tang, Jing Wang, Tingting Hu, Haoning Zhang, Jian Chen, Zhen Kang   +5 more
doaj   +1 more source

Protein templates for the biosynthesis of peptide antibiotics

Chemistry & Biology, 1997
Peptide synthetases of microbial origin can act as protein templates for the biosynthesis of unusual, often pharmacologically active, peptides of diverse structure and biological activity. Specific repeated modules in the synthetases each contain at least two distinct domains, required for substrate adenylation and thiolation, that define the sequence ...
openaire   +2 more sources