Results 61 to 70 of about 200,892 (306)

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Investigating the chemistry of lipoyl synthase [PDF]

, 2008
The radical SAM protein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into the unactivated C6 and C8 centres of a protein-bound octanoyl group.
Douglas, Paul
core  

Cell wall assembly in Bacillus megaterium: incorporation of new peptidoglycan by a monomer addition process [PDF]

, 1991
The pattern of cross-linking in the peptidoglycan of Bacillus megaterium has been studied by the pulsed addition of radiolabeled diaminopimelic acid.
D L Gally, I C Hancock, C R Harwood, A R Archibald, Harwood, Colin R., Archibald, A.R., Hancock, Ian C., Gally, David   +7 more
core   +1 more source

Unveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis

iScience
Summary: Glycopeptide antibiotics (GPA) such as vancomycin are essential last-resort antibiotics produced by actinomycetes. Their biosynthesis is encoded within biosynthetic gene clusters, also harboring genes for regulation, and transport. Diverse types
Nicola Gericke, Dardan Beqaj, Thales Kronenberger, Andreas Kulik, Athina Gavriilidou, Mirita Franz-Wachtel, Ulrich Schoppmeier, Theresa Harbig, Johanna Rapp, Iwan Grin, Nadine Ziemert, Hannes Link, Kay Nieselt, Boris Macek, Wolfgang Wohlleben, Evi Stegmann, Samuel Wagner   +16 more
doaj   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

Structure and biosynthesis of fungal secondary metabolites [PDF]

, 2013
The root rot pathogen Heterobasidion annosum s.l., i.e. H. abietinum, H. parviporum, H. annosum s.s., H. irregulare and H. occidentale, and the biocontrol fungus Phlebiopsis gigantea were investigated regarding their secondary metabolites.
Hansson, David
core  

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host

Scientific Reports, 2017
Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenecks impeding ...
Keita Amagai, Haruo Ikeda, Junko Hashimoto, Ikuko Kozone, Miho Izumikawa, Fumitaka Kudo, Tadashi Eguchi, Takemichi Nakamura, Hiroyuki Osada, Shunji Takahashi, Kazuo Shin-ya   +10 more
doaj   +1 more source

E. coli Extracellular Matrix: A Tunable Composite With Hierarchical Structure

Advanced Materials, EarlyView.
The complex composite‐like mechanical behavior of E. coli biofilm matrix is the result of a synergic contribution of the rigid curli and swelling pEtN‐cellulose, and emerges from specific ratio and assembly conditions. The interactions between the two fibers govern biofilm hydration and characteristic wrinkling patterns, providing crucial insights for ...
Macarena Siri, Agustín Mangiarotti, Anne Seewald, Nikolai Rosenthal, Shahrouz Amini, Emeline Raguin, Peter Fratzl, Cécile M. Bidan   +7 more
wiley   +1 more source

MS [PDF]

, 2007
thesisSaframycin-like ecteinascidins and patellamides are two groups of cytotoxic marine peptide natural products with potential application as anticancer therapeutics. The biosynthesis of the saframycins occurs through nonribosomal peptide synthesis and
Nelson, James Thomas
core  

Synthetic biology of fungal natural products [PDF]

, 2015
This work was supported by the DFG-funded excellence graduate school Jena School for Microbial Communication (JSMC; DJM, AAB), the collaborative research center (SFB) 1127 Chemical Mediators in Complex Biosystems (ChemBioSys—AAB, project B02) and the ...
Vito Valiante, Unkles, S.E., Mattern, D.J., Valiante, V., Brakhage, A.A., Derek J. Mattern, Axel A. Brakhage, Shiela E. Unkles   +7 more
core   +1 more source