Results 41 to 50 of about 359,289 (223)

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]

, 2015
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D, Jain, Rishi K, Merrick, William C, Miller, Howard R, Ross, Nathan T, Sethofer, Steven G, Simard, Jillian L, Smith, Geoffrey A, Taunton, Jack   +8 more
core   +2 more sources

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy [PDF]

, 2015
Structural analysis of protein fibrillation is inherently challenging. Given the crucial role of fibrils in amyloid diseases, method advancement is urgently needed.
Annette E. Langkilde, Balbirnie, Bente Vestergaard, Berryman, Berryman, Blanchet, Cecchi, Collins, Debelouchina, Diaz-Avalos, Dmitri I. Svergun, Dunbrack, Eisenberg, Esposito, Fitzpatrick, Franke, Giehm, Gras, Jiménez, Kantardjieff, Knowles, Konarev, Kyle L. Morris, Langkilde, Langkilde, Lewandowski, Louise C. Serpell, Makin, Marshall, Morris, Narayanan, Nasica-Labouze, Nelson, Oliveira, Periole, Pettersen, Powers, Qi, Reches, Sawaya, Sikorski, Strodel, Stroud, Sunde, Svergun, Svergun, Vestergaard, Wel, Wel, Wickner, Wiltzius   +50 more
core   +1 more source

Using high-abundance proteins as guides for fast and effective peptide/protein identification from human gut metaproteomic data

Microbiome, 2021
Background A few recent large efforts significantly expanded the collection of human-associated bacterial genomes, which now contains thousands of entities including reference complete/draft genomes and metagenome assembled genomes (MAGs).
Moses Stamboulian, Sujun Li, Yuzhen Ye
doaj   +1 more source

Cotranslational folding of proteins on the ribosome.

, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]

, 2019
During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R., Bock, L., Grubmüller, H., Peng, B., Peske, F., Rodnina, M.   +5 more
core   +2 more sources

Role of peptide chain elongation factor G in guanosine 5'-diphosphate 3'-diphosphate synthesis. [PDF]

Journal of Bacteriology, 1981
In a wild-type strain (relA+) of Escherichia coli, starvation of amino acid led to an immediate cessation of the synthesis of stable ribonucleic acids, together with the accumulation of an unusual nucleotide, guanosine 5'-diphosphate 3'-diphosphate, commonly known as ppGpp. This compound also accumulated during heat shock.
C C, Pao, J, Fleckenstein, B T, Dyess
openaire   +2 more sources

Protein charge distribution in proteomes and its impact on translation. [PDF]

PLoS Computational Biology, 2017
As proteins are synthesized, the nascent polypeptide must pass through a negatively charged exit tunnel. During this stage, positively charged stretches can interact with the ribosome walls and slow the translation. Therefore, charged polypeptides may be
Rodrigo D Requião, Luiza Fernandes, Henrique José Araujo de Souza, Silvana Rossetto, Tatiana Domitrovic, Fernando L Palhano   +5 more
doaj   +1 more source

Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]

, 2017
In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M, Conn, Adam B, Diggs, Stephen, Fan, Haitian, Gamper, Howard B, Hahm, Joseph, Hou, Ya-Ming, O'Leary, Seán E, Wang, Yinsheng, Williams, Preston B   +9 more
core   +1 more source

Extensive evolution of cereal ribosome-inactivating proteins translates into unique structural features, activation mechanisms, and physiological roles [PDF]

, 2017
Ribosome-inactivating proteins (RIPs) are a class of cytotoxic enzymes that can depurinate rRNAs thereby inhibiting protein translation. Although these proteins have also been detected in bacteria, fungi, and even some insects, they are especially ...
De Zaeytijd, Jeroen, Van Damme, Els
core   +2 more sources

Complex Formation of the Elongation Factor Tu from Pseudomonas aeruginosa with Nucleoside Diphosphate Kinase Modulates Ribosomal GTP Synthesis and Peptide Chain Elongation [PDF]

Journal of Biological Chemistry, 1997
The elongation factor Tu (EF-Tu) from Pseudomonas aeruginosa was purified as a 45-kDa polypeptide that forms a complex with both the 12- and 16-kDa forms of nucleoside-diphosphate kinase (Ndk) and predominantly synthesizes GTP. 70 S ribosomes of P. aeruginosa predominantly synthesize GTP, which is inhibited in presence of anti-Ndk antibodies.
S, Mukhopadhyay, S, Shankar, W, Walden, A M, Chakrabarty   +3 more
openaire   +2 more sources