Results 51 to 60 of about 359,289 (223)

The PSY Peptide Family—Expression, Modification and Physiological Implications

Genes, 2021
Small post-translationally modified peptides are gaining increasing attention as important signaling molecules in plant development. In the family of plant peptides containing tyrosine sulfation (PSYs), only PSY1 has been characterized at the mature ...
Amalie Scheel Tost, A. Kristensen, L. I. Olsen, K. Axelsen, A. Fuglsang   +4 more
semanticscholar   +1 more source

METTL13 methylation of eEF1A increases translational output to promote tumorigenesis [PDF]

, 2019
Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to ...
Bassik, Michael Cory, Caporicci, Marcello, Carlson, Scott Moore, Elias, Joshua Eric, Francis, Joel William, Fuentes, Mary Esmeralda, Gozani, Or, Hausmann, Simone, Hulea, Laura, Kim, Michael Paul, Li, Ami, Liu, Shuo, Lofgren, Shane Michael, Lu, Jiuwei, Maitra, Anirban, Mazur, Pawel Karol, Nicholas, Dang Nguyen, Pillai, Renjitha, Porco, John Anthony, Song, Jikui, Tandoc, Kristofferson, Topisirovic, Ivan, Van Rechem, Capucine, Wang, Huamin, Wistuba, Ignacio Ivan   +24 more
core   +1 more source

Reversing the relative time courses of the peptide bond reaction with oligopeptides of different lengths and charged amino acid distributions in the ribosome exit tunnel

Computational and Structural Biotechnology Journal
The kinetics of the protein elongation cycle by the ribosome depends on intertwined factors. One of these factors is the electrostatic interaction of the nascent protein with the ribosome exit tunnel.
Marc Joiret, Frederic Kerff, Francesca Rapino, Pierre Close, Liesbet Geris   +4 more
doaj   +1 more source

Molecular dynamics of ribosomal elongation factors G and Tu

European Biophysics Journal, 2010
Translation on the ribosome is controlled by external factors. During polypeptide lengthening, elongation factors EF-Tu and EF-G consecutively interact with the bacterial ribosome. EF-Tu binds and delivers an aminoacyl-tRNA to the ribosomal A site and EF-
K. Kulczycka, M. Długosz, J. Trylska
semanticscholar   +1 more source

Elongation factor 2-diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions [PDF]

, 2013
Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A role for eEF2 in cellular stress responses is highlighted by the fact that eEF2 is sensitive to
Argüelles Castilla, Sandro, Ayala Gómez, Antonio, Camandola, Simonetta, Cutler, Roy G.   +3 more
core   +1 more source

Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity

BMC Plant Biology, 2008
Background Latest research shows that small antimicrobial peptides play a role in the innate defense system of plants. These peptides typically contribute to preformed defense by developing protective barriers around germinating seeds or between ...
Vivier Melané A, de Beer Abré
doaj   +1 more source

Molecular Simulations of the Ribosome and Associated Translation Factors

, 2014
The ribosome is a macromolecular complex which is responsible for protein synthesis in all living cells according to their transcribed genetic information.
Hamed H. Alsulami (532535), Muhammad Bilal Ashraf (532534), Muhammad Shahab Alhuthali (532536), Tasawar Hayat (433317)   +3 more
core   +6 more sources

Ricin trafficking in plant and mammalian cells [PDF]

, 2011
Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core   +2 more sources

Stoichiometry and Change of the mRNA Closed-Loop Factors as Translating Ribosomes Transit from Initiation to Elongation [PDF]

, 2016
Protein synthesis is a highly efficient process and is under exacting control. Yet, the actual abundance of translation factors present in translating complexes and how these abundances change during the transit of a ribosome across an mRNA remains ...
Chiang, Yueh-Chin, Denis, Clyde L., Hasek, Jiri, Laue, Thomas M., Toomey, Shaun, Wang, Xin, Xi, Wen   +6 more
core   +4 more sources

The gene YEF3 function encoding translation elongation factor eEF3 is partially conserved across fungi

Frontiers in Microbiology
IntroductionTranslation is a fundamental process of life. In eukaryotes, the elongation step of translation is highly conserved and is driven by eukaryotic translation elongation factors (eEF)1A and eEF2.
Giovanna Maldonado, Alejandra García, Saturnino Herrero, Irene Castaño, Michael Altmann, Reinhard Fischer, Greco Hernández, Greco Hernández   +7 more
doaj   +1 more source