Results 261 to 270 of about 53,655 (285)

Membrane-Disrupting Nanofibrous Peptide Hydrogels

ACS Biomaterials Science & Engineering, 2019
Self-assembled peptide nanofibers can form biomimetic hydrogels at physiological pH and ionic strength through noncovalent and reversible interactions. Inspired by natural antimicrobial peptides, we designed a class of cationic amphiphilic self-assembled peptides (CASPs) that self-assemble into thixotropic nanofibrous hydrogels. These constructs employ
Biplab Sarkar, Zain Siddiqui, Peter K. Nguyen, Namita Dube, Wanyi Fu, Steven Park, Shivani Jaisinghani, Reshma Paul, Stephen D. Kozuch, Daiyong Deng, Patricia Iglesias-Montoro, Mengyan Li, David Sabatino, David S. Perlin, Wen Zhang, Jagannath Mondal, Vivek A. Kumar   +16 more
openaire   +2 more sources

Proangiogenic Peptide Nanofiber Hydrogels for Wound Healing

ACS Biomaterials Science & Engineering, 2021
Rapid vascularization is vital for dermal regeneration, nutrient and nutrition transfer, metabolic waste removal, and prevention of infection. This study reports on a series of proangiogenic peptides designed to undergo self-assembly and promote angiogenesis and hence skin regeneration. The proangiogenic peptides comprised an angiogenic peptide segment,
Bin Chu, Jin-Mei He, Lan-Lan Liu, Chao-Xi Wu, Ling-Ling You, Xiao-Li Li, Song Wang, Chang-Sheng Chen, Mei Tu   +8 more
openaire   +2 more sources

Peptide hydrogels: mimicking the extracellular matrix

Bioinspired, Biomimetic and Nanobiomaterials, 2012
The extracellular matrix (ECM) is a complex and dynamic three-dimensional (3D) environment consisting largely of a variety of collagenous and non-collagenous fibres, non-fibrous proteins and proteoglycans. Other components often overlooked include various growth factors and other signalling molecules which can diffuse through and bind to various ...
Gough, JE, Saiani, A, Miller, AF
openaire   +1 more source

Branched peptides for enzymatic supramolecular hydrogelation

Chemical Communications, 2018
The use of protease (e.g., enterokinase) to cut branched peptides generates supramolecular hydrogels, opening a new way to explore soft materials for biomedicine.
Hongjian He, Huaimin Wang, Ning Zhou, Dongsik Yang, Bing Xu   +4 more
openaire   +2 more sources

Hybrid Peptide–Agarose Hydrogels for 3D Immunoassays

2022
Recent advances in biosensing analytical platforms have brought relevant outcomes for novel diagnostic and therapy-oriented applications. In this context, 3D droplet microarrays, where hydrogels are used as matrices to stably entrap biomolecules onto analytical surfaces, potentially provide relevant advantages over conventional 2D assays, such as ...
Angelo Musicò, Greta Bergamaschi, Alessandro Strada, Roberto Frigerio, Paola Gagni, Marina Cretich, Alessandro Gori   +6 more
openaire   +4 more sources

pH-Responsive Biocompatible Supramolecular Peptide Hydrogel

The Journal of Physical Chemistry B, 2019
Peptide-based hydrogels are highly promising for various biomedical applications owing to their precise self-assembly, biocompatibility, and sensitivity toward biologically relevant external stimuli. Herein, we report pH-responsive self-assembly and gelation of a highly biocompatible amphiphilic peptide PEP-1.
Goutam Ghosh, Ranajit Barman, Jayita Sarkar, Suhrit Ghosh   +3 more
openaire   +2 more sources

Tethered protein/peptide-surface-modified hydrogels

Journal of Biomaterials Science, Polymer Edition, 2004
We investigated a wet chemistry method to covalently bond polyethylene glycol (PEG)-tethered extracellular matrix (ECM) proteins (laminin and fibronectin) or peptide (fibronectin-adhesion-peptide sequence) onto the surface of a poly(2-hydroxylethyl methacrylate-co-methylacrylic acid) (PHEMA/MAA) hydrogel that could potentially be used as a replacement ...
Jingjing, Bi, J Crawford, Downs, Jean T, Jacob   +2 more
openaire   +2 more sources

Mechanics of single peptide hydrogelator fibrils

Nanoscale, 2015
The rigidity of peptide fibers is essential for their chemical and biological functions, despite that it remains largely unexplored.
Ying, Li, Yang, Sun, Meng, Qin, Yi, Cao, Wei, Wang   +4 more
openaire   +2 more sources

Hydrogel Formation with Enzyme-Responsive Cyclic Peptides

2021
Self-assembling peptides (SAPs), which form hydrogels through physical cross-linking of soluble structures, are an intriguing class of materials that have been applied as tissue engineering scaffolds and drug delivery vehicles. For feasible application of these tissue mimetics via minimally invasive delivery, their bulk mechanical properties must be ...
Andrea S, Carlini, Mary F, Cassidy, Nathan C, Gianneschi   +2 more
openaire   +2 more sources

Self-Assembling Peptide/Thermoresponsive Polymer Composite Hydrogels: Effect of Peptide–Polymer Interactions on Hydrogel Properties

Langmuir, 2014
We have investigated the effect of doping the self-assembling octapeptide FEFEFKFK (F, phenylalanine; E, glutamic acid; K, lysine) hydrogels with various amounts of thermoresponsive conjugate of FEFEFKFK and poly(N-isopropylacrylamide) (PNIPAAm) in order to create novel hydrogels.
Maslovskis, A, Guilbaud, J B, Grillo, I, Hodson, N, Miller, A F, Saiani, A   +5 more
openaire   +2 more sources