Results 31 to 40 of about 995,438 (315)

Est10: A Novel Alkaline Esterase Isolated from Bovine Rumen Belonging to the New Family XV of Lipolytic Enzymes. [PDF]

open access: yesPLoS ONE, 2015
A metagenomic fosmid library from bovine rumen was used to identify clones with lipolytic activity. One positive clone was isolated. The gene responsible for the observed phenotype was identified by in vitro transposon mutagenesis and sequencing and was ...
María Cecilia Rodríguez   +6 more
doaj   +1 more source

Surface-modified vacuole-based daunorubicin delivery system for acute myeloid leukaemia (AML) and their selective therapeutics

open access: yesArtificial Cells, Nanomedicine, and Biotechnology, 2022
The vacuoles in Saccharomyces cerevisiae are the key players digesting the waste within the cell. This functional organelle corresponding to the lysosome of mammalians contains acidic hydrolases and specific membrane proteins.
Wooil Choi, Yang-Hoon Kim, Jiho Min
doaj   +1 more source

The action of Metaloproteinases in the Atherosclerotic Diseases

open access: yesABCS Health Sciences, 2014
Cardiovascular diseases represent the main cause of morbidity and mortality in the world and are epidemic events involving the atherosclerosis and coronary artery disease in particular.
Álvaro Luís Müller da Fonseca   +2 more
doaj   +1 more source

The peptide hydrolase system of Lactobacillus reuteri

open access: yesInternational Journal of Food Microbiology, 2001
Peptide hydrolase system of Lactobacillus reuteri CRL 1098, a lactic acid bacteria of sourdough origin, was investigated. This microorganism has a broad range of peptidases consisting of an active aminopeptidase, X-Prolyl-dipeptidylaminopeptidase, dipeptidase and tripeptidase.
Rollan, Graciela Celestina   +1 more
openaire   +3 more sources

Supramolecular enzyme-mimicking catalysts self-assembled from peptides

open access: yesiScience, 2023
Summary: Natural enzymes catalyze biochemical transformations in superior catalytic efficiency and remarkable substrate specificity. The excellent catalytic repertoire of enzymes is attributed to the sophisticated chemical structures of their active ...
Qing Liu, Akinori Kuzuya, Zhen-Gang Wang
doaj   +1 more source

Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway

open access: yesBiomolecules, 2020
The N-degron pathway is a proteolytic system in which a single N-terminal amino acid acts as a determinant of protein degradation. Especially, degradation signaling of N-terminal asparagine (Nt-Asn) in eukaryotes is initiated from its deamidation by N ...
Joon Sung Park   +8 more
doaj   +1 more source

Chimeric Peptidoglycan Hydrolases Kill Staphylococcal Mastitis Isolates in Raw Milk and within Bovine Mammary Gland Epithelial Cells

open access: yesViruses, 2022
Staphylococcus aureus is a major causative agent of bovine mastitis, a disease considered one of the most economically devastating in the dairy sector.
Anja P. Keller   +5 more
doaj   +1 more source

Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile

open access: yesMicrobial Cell, 2018
Clostridium difficile, also known as Clostriodioides difficile, is a Gram positive, spore-forming bacterium and a leading cause of antibiotic-associated diarrhea in nosocomial environments. The key virulence factors of this pathogen are two toxins, toxin
Imane El Meouche, Johann Peltier
doaj   +1 more source

Cathepsin E (EC 3.4.23.34) — a review

open access: yesFolia Histochemica et Cytobiologica, 2012
Cathepsin E belongs to the third class of enzymes — hydrolases, a subclass of peptide bond hydrolases and a sub-subclass of endopeptidases with aspartic catalytic sites. Cathepsin E is an endopeptidase with substrate specificity similar to that
Anna Worowska   +3 more
doaj   +1 more source

Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection

open access: yesmBio, 2023
The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses of antibiotics over the course of several weeks.
Anja P. Keller   +14 more
doaj   +1 more source

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