Results 61 to 70 of about 32,792 (197)

Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

Food Science and Human Wellness
The main proteases (Mpros) are hydrolases playing essential roles in the replication of β-coronaviruses including SARS-CoV-2. Herein, a highly efficient strategy was developed for discovering the Mpro inactivators from crude plant extract integrating ...
Guanghao Zhu, Yani Zhang, Shenglan Qi, Jianrong Xu, Yuan Xiong, Zhaoqin Zhang, Xixiang Chen, Yuanyuan Xie, Xiaoqing Guan, Weidong Zhang, Wei Liu, Guangbo Ge   +11 more
doaj   +1 more source

Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres

Marine Drugs, 2017
Tachyplesin I is a cationic peptide isolated from hemocytes of the horseshoe crab and its anti-tumor activity has been demonstrated in several tumor cells. However, there is limited information providing the global effects and mechanisms of tachyplesin I
Xuan Li, Jianguo Dai, Yongjun Tang, Lulu Li, Gang Jin   +4 more
doaj   +1 more source

Activation of pineal acetyl coenzyme A hydrolase by disulfide peptides.

Journal of Biological Chemistry, 1982
Incubation of pineal acetyl-CoA hydrolase preparations with disulfide peptides activates the enzyme. Activation of somatostatin, the most potent peptide tested, is enhanced at higher pH, indicating that disulfide exchange is probably involved. This interpretation is supported by the observation that activation is reversed by dithiothreitol treatment ...
J. T. Favilla, M. A. A. Namboodiri, David C. Klein   +2 more
openaire   +3 more sources

The subcellular localization of di- and tri-peptide hydrolase activity in guinea-pig small intestine [PDF]

, 1970
Timothy J. Peters
openalex   +1 more source

Shotgun proteomic analysis of Anaeroglobus geminatus

Journal of Oral Microbiology, 2017
Objectives: Anaeroglobus geminatus is a gram-negative species belonging to the family of Veillonellaceae and close associate to genus Megasphaera. The role of the species within dysbiotic microbial communities is not yet clear.
Kai Bao, Nagihan Bostanci, Thomas Thurnheer, Georgios N. Belibasakis   +3 more
doaj   +1 more source

Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease [PDF]

, 1970
Adrian P. Douglas, T. J. Peters
openalex   +1 more source

Partial Purification and Characterization of Two Peptide Hydrolases from Pea Seeds [PDF]

, 1976
J. Bruce Caldwell, Lindsay G. Sparrow
openalex   +1 more source

Removal of N‐acetyl groups from blocked peptides with acylpeptide hydrolase [PDF]

, 1991
T C Farries, Alan Harris, Anthony D. Auffret, Alastair Aitken   +3 more
openalex   +1 more source

Bifunctional quorum-quenching and antibiotic-acylase MacQ forms a 170-kDa capsule-shaped molecule containing spacer polypeptides

Scientific Reports, 2017
Understanding the molecular mechanisms of bacterial antibiotic resistance will help prepare against further emergence of multi-drug resistant strains. MacQ is an enzyme responsible for the multi-drug resistance of Acidovorax sp. strain MR-S7.
Yoshiaki Yasutake, Hiroyuki Kusada, Teppei Ebuchi, Satoshi Hanada, Yoichi Kamagata, Tomohiro Tamura, Nobutada Kimura   +6 more
doaj   +1 more source

Identification of proteins that interact with mammalian peptide: N -glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation [PDF]

, 2001
Hangil Park, Tadashi Suzuki, William J. Lennarz   +2 more
openalex   +1 more source