Results 71 to 80 of about 934,930 (177)

Structural Stability and Immunogenicity of Peptides [PDF]

arXiv, 2010
We investigated the role of peptide folding stability in peptide immunogenicity. It was the aim of this thesis to implement a stability criterion based on energy computations using an AMBER force field, and to test the implementation with a large dataset.
arxiv  

Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres

Marine Drugs, 2017
Tachyplesin I is a cationic peptide isolated from hemocytes of the horseshoe crab and its anti-tumor activity has been demonstrated in several tumor cells. However, there is limited information providing the global effects and mechanisms of tachyplesin I
Xuan Li, Jianguo Dai, Yongjun Tang, Lulu Li, Gang Jin   +4 more
doaj   +1 more source

Computational analysis of sequential and structural variations in stromelysins as an insight towards matrix metalloproteinase research

Informatics in Medicine Unlocked, 2018
Matrix metalloproteinases are zinc-dependent protein and peptide hydrolases. They are broadly involved in metabolic regulation through both extensive protein degradation and selective peptide-bond hydrolysis.
Beutline Malgija, Host Antony David Rajendran, Uma Maheswari, Nivetha Sarah Ebenezer, Joyce Priyakumari, Shanmughavel Piramanayagam   +5 more
doaj  

The subcellular localization of di- and tri-peptide hydrolase activity in guinea-pig small intestine [PDF]

, 1970
Timothy J. Peters
openalex   +1 more source

Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension [PDF]

arXiv
Peptides, short chains of amino acids, interact with target proteins, making them a unique class of protein-based therapeutics for treating human diseases. Recently, deep generative models have shown great promise in peptide generation. However, several challenges remain in designing effective peptide binders. First, not all residues contribute equally
arxiv  

Shotgun proteomic analysis of Anaeroglobus geminatus

Journal of Oral Microbiology, 2017
Objectives: Anaeroglobus geminatus is a gram-negative species belonging to the family of Veillonellaceae and close associate to genus Megasphaera. The role of the species within dysbiotic microbial communities is not yet clear.
Kai Bao, Nagihan Bostanci, Thomas Thurnheer, Georgios N. Belibasakis   +3 more
doaj   +1 more source

Peptide hydrolase activity of human intestinal mucosa in adult coeliac disease [PDF]

, 1970
Adrian P. Douglas, T. J. Peters
openalex   +1 more source

Suppression of a Prolyl 4 Hydroxylase Results in Delayed Abscission of Overripe Tomato Fruits

Frontiers in Plant Science, 2019
The tomato pedicel abscission zone (AZ) is considered a model system for flower and fruit abscission development, activation, and progression. O-glycosylated proteins such as the Arabidopsis IDA (INFLORESCENCE DEFICIENT IN ABSCISSION) peptide and ...
Andreas Perrakis, Craita E. Bita, Stilianos Arhondakis, Afrodite Krokida, Khansa Mekkaoui, Dusan Denic, Konstantinos N. Blazakis, Dimitrios Kaloudas, Panagiotis Kalaitzis   +8 more
doaj   +1 more source

AMP0: Species-Specific Prediction of Anti-microbial Peptides using Zero and Few Shot Learning [PDF]

arXiv, 2019
The evolution of drug-resistant microbial species is one of the major challenges to global health. The development of new antimicrobial treatments such as antimicrobial peptides needs to be accelerated to combat this threat. However, the discovery of novel antimicrobial peptides is hampered by low-throughput biochemical assays. Computational techniques
arxiv  

Target-Specific De Novo Peptide Binder Design with DiffPepBuilder [PDF]

arXiv
Despite the exciting progress in target-specific de novo protein binder design, peptide binder design remains challenging due to the flexibility of peptide structures and the scarcity of protein-peptide complex structure data. In this study, we curated a large synthetic dataset, referred to as PepPC-F, from the abundant protein-protein interface data ...
arxiv