Results 171 to 180 of about 423,793 (299)

Artificial Multidomain Ribosomally Synthesized and Post-translationally Modified Peptide Enzymes for Farnesylated Peptide Library Generation. [PDF]

ACS Synth Biol
Lacerna N, Schmidt EW.
europepmc   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Screening and Identification of a Specific Binding Peptide to Ovarian Cancer Cells from a Phage-Displayed Peptide Library. [PDF]

Int J Pept Res Ther, 2021
Zhao S, Li C, Gao Y, Qian L, Dong J, Zhai L, Chen B, Zhang J.   +7 more
europepmc   +1 more source

Peptide Library

Kobunshi, 1993
openaire   +2 more sources

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

A Placenta Derived C-Terminal Fragment of beta-Hemoglobin With Combined Antibacterial and Antiviral Activity

, 2020
Bauer, R., Conzelmann, C., Forssmann, W., Gačanin, J., Gerbl, F., Groß, R., Hagemann, B., Kirchhoff, F., Krüger, F., Mankertz, A., Münch, J., Olari, L., Preising, N., Rodríguez, A., Ruiz-Blanco, Y., Rücker-Braun, E., Sanchez-Garcia, E., Santibanez, S., Sauter, D., Spellerberg, B., Stenger, S., Ständker, L., Walther, P., Weil, T., Wiese, S.   +24 more
core   +1 more source

Identification of a Glypican-3 Binding Peptide From a Phage-Displayed Peptide Library for PET Imaging of Hepatocellular Carcinoma. [PDF]

Front Oncol, 2021
Yan J, Yu X, Chen X, Liu F, Chen F, Ding N, Yu L, Meng F, Shen J, Wei J, Liu B.   +10 more
europepmc   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors. [PDF]

Adv Sci (Weinh)
Brennan A, Lovell S, Vance KW, Mason JM.
europepmc   +1 more source

Combined computational and intracellular peptide library screening: towards a potent and selective Fra1 inhibitor. [PDF]

RSC Chem Biol, 2021
Yu M, Ghamsari L, Rotolo JA, Kappel BJ, Mason JM.   +4 more
europepmc   +1 more source