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Combinatorial Chemistry & High Throughput Screening, 2008
Peptide aptamers are molecules that bind to protein targets and are able to interfere with their functions. In the past, important achievements have been made using such peptide aptamers in different approaches and for various purposes. Peptide aptamers are comprised of a variable peptide region of 8 to 20 amino acids in length, which is displayed by a
Corina, Borghouts +2 more
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Peptide aptamers are molecules that bind to protein targets and are able to interfere with their functions. In the past, important achievements have been made using such peptide aptamers in different approaches and for various purposes. Peptide aptamers are comprised of a variable peptide region of 8 to 20 amino acids in length, which is displayed by a
Corina, Borghouts +2 more
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Current Opinion in Biotechnology, 1994
Over the past year, great strides have been made in the design of peptide libraries, and new approaches have been developed for identifying peptide ligands. The libraries comprise large collections of peptides, ranging from 1 million to 1 billion different sequences, which can be screened using monoclonal and polyclonal antibodies, receptors, enzymes ...
J K, Scott, L, Craig
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Over the past year, great strides have been made in the design of peptide libraries, and new approaches have been developed for identifying peptide ligands. The libraries comprise large collections of peptides, ranging from 1 million to 1 billion different sequences, which can be screened using monoclonal and polyclonal antibodies, receptors, enzymes ...
J K, Scott, L, Craig
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Phage Displayed Peptide Libraries
Combinatorial Chemistry & High Throughput Screening, 1999Peptide libraries may be constructed by grafting, in vitro, random DNA sequences into a carrier gene and then introducing the degenerate hybrid coding sequence into an expression organism. This review will focus on phage display, which was the first expression organism for peptide library expression to be described and which still maintains ...
Cesareni G, Castagnoli L, Cestra G
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A Conformationally Homogeneous Combinatorial Peptide Library
Journal of Molecular Biology, 1995In search for a rational way to convert the information encoded in peptide structures into peptidomimetics, major progress could be made by coupling the power of selection methods, now enormously increased in number as a result of the development of combinatorial peptide libraries, with the rational design of structure-inducing templates for the ...
BIANCHI E +10 more
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Peptide libraries: criteria and trends
Trends in Genetics, 1993The development of approaches for preparing peptide libraries, containing millions of different amino acid sequences of a specified length, provides an invaluable resource for characterizing the molecular interactions that underlie many biological processes.
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Methods in enzymology, 1997
Combinatorial chemistry is a rapidly developing field. It is now considered as one of the most important recent advances in medicinal chemistry. In addition to drug lead identification, combinatorial chemistry can also be applied to the optimization of the initial lead.
Zhan-Gong Zhao, Kit S. Lam
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Combinatorial chemistry is a rapidly developing field. It is now considered as one of the most important recent advances in medicinal chemistry. In addition to drug lead identification, combinatorial chemistry can also be applied to the optimization of the initial lead.
Zhan-Gong Zhao, Kit S. Lam
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Peptide and Non-Peptide Combinatorial Libraries
2006The field of combinatorial peptide chemistry was created when the first limited peptide library was synthesized with multipin technology in 1984. Since 1990, the field of combinatorial chemistry has advanced rapidly. It has emerged as a powerful tool in the study of many biological systems. In essence, a combinatorial peptide library (numbering 104–108
Ruiwu Liu, Kit S. Lam
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Methods, 1996
Filamentous phage particles have been central in the construction of libraries displaying vast numbers of random peptides. These random peptides can be antigenically presented as fusions to coat proteins III and VIII of the phage. The isolation of ligate-reactive phage from an immense background of nonspecific phage is achieved by the biopanning ...
, Daniels, , Lane
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Filamentous phage particles have been central in the construction of libraries displaying vast numbers of random peptides. These random peptides can be antigenically presented as fusions to coat proteins III and VIII of the phage. The isolation of ligate-reactive phage from an immense background of nonspecific phage is achieved by the biopanning ...
, Daniels, , Lane
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Peptide and Peptide Library Cyclization via Bromomethylbenzene Derivatives
2014Cyclization confers several advantages to peptides, cumulatively serving to make them more drug-like. In this protocol, cyclic peptides are generated via bis-alkylation of cysteine-containing peptides using α,α'-dibromo-m-xylene. The reactions are robust and high yielding.
David E, Hacker +4 more
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1998
Abstract Chapters 2 and 3 described the explosive growth in methods for the rapid synthesis of peptide libraries, primarily for immunological studies, reflecting the critical role played by solid phase peptide chemists in the initial development of combinatorial chemistry methods. Following the seminal 1991 Naturepapers from Houghton and
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Abstract Chapters 2 and 3 described the explosive growth in methods for the rapid synthesis of peptide libraries, primarily for immunological studies, reflecting the critical role played by solid phase peptide chemists in the initial development of combinatorial chemistry methods. Following the seminal 1991 Naturepapers from Houghton and
openaire +1 more source