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DNA-Encoded Macrocyclic Peptide Library
2019DNA-encoded library technology (ELT) is a cutting-edge enabling technology platform for drug discovery. Here we describe how to design and synthesize a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity.
Zhengrong, Zhu +7 more
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Peptide and Peptide Library Cyclization via Bromomethylbenzene Derivatives
2014Cyclization confers several advantages to peptides, cumulatively serving to make them more drug-like. In this protocol, cyclic peptides are generated via bis-alkylation of cysteine-containing peptides using α,α'-dibromo-m-xylene. The reactions are robust and high yielding.
David E, Hacker +4 more
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Peptide libraries: criteria and trends
Trends in Genetics, 1993The development of approaches for preparing peptide libraries, containing millions of different amino acid sequences of a specified length, provides an invaluable resource for characterizing the molecular interactions that underlie many biological processes.
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Peptide and Non-Peptide Combinatorial Libraries
2006The field of combinatorial peptide chemistry was created when the first limited peptide library was synthesized with multipin technology in 1984. Since 1990, the field of combinatorial chemistry has advanced rapidly. It has emerged as a powerful tool in the study of many biological systems. In essence, a combinatorial peptide library (numbering 104–108
Ruiwu Liu, Kit S. Lam
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Implicit Biology in Peptide Spectral Libraries
Analytical Chemistry, 2012Mass spectral libraries are collections of mass spectra curated specifically to facilitate the identification of small molecules, metabolites, and short peptides. One of the most comprehensive peptide spectral libraries is curated by NIST and contains upward of half a million annotated spectra dominated by human and model organisms including budding ...
Askenazi, Manor, Linial, Michal
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Screening Phage-Displayed Combinatorial Peptide Libraries
Methods, 2001Among the many techniques available to investigators interested in mapping protein-protein interactions is phage display. With a modest amount of effort, time, and cost, one can select peptide ligands to a wide array of targets from phage-display combinatorial peptide libraries.
B K, Kay, J, Kasanov, M, Yamabhai
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Epitope mapping using bacteriophage peptide libraries
Current Opinion in Immunology, 1993Vast libraries of random peptides displayed on the surface of bacteriophage potentially allow identification of specific ligands for any peptide receptor of interest. The sequence specificity of antibody-peptide interactions allows these libraries to be used to define and localize continuous epitopes.
D P, Lane, C W, Stephen
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1998
Abstract Chapters 2 and 3 described the explosive growth in methods for the rapid synthesis of peptide libraries, primarily for immunological studies, reflecting the critical role played by solid phase peptide chemists in the initial development of combinatorial chemistry methods. Following the seminal 1991 Naturepapers from Houghton and
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Abstract Chapters 2 and 3 described the explosive growth in methods for the rapid synthesis of peptide libraries, primarily for immunological studies, reflecting the critical role played by solid phase peptide chemists in the initial development of combinatorial chemistry methods. Following the seminal 1991 Naturepapers from Houghton and
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Peptide Libraries in Cellular Immune Recognition
1999Protective immunity against microbial pathogens is connected with the ability to discriminate between self and non-self. Vertebrates have evolved an adaptive immune system in which specialized white blood cells, the T cells, fulfill this role. These cells are trained to recognize proteolytic fragments of viral, bacterial or parasitic antigens in the ...
S, Uebel +3 more
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Combinatorial Peptide Library Protocols
1997Synthesis of a One-Bead One-Compound Combinatorial Peptide Library Kit S. Lam and Michal Lebl. Enzyme-Linked Colorimetric Screening of a One-Bead One-Compound Combinatorial Library Kit S. Lam. Synthesis and Screening of Positional Scanning Combinatorial Libraries Colette T. Dooley and Richard A. Houghten. Synthesis and Screening of Peptide Libraries on
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