Results 331 to 340 of about 379,196 (358)

Peptide libraries: at the crossroads of proteomics and bioinformatics

Current Opinion in Chemical Biology, 2003
Peptide libraries offer a valuable means for providing functional information regarding protein-modifying enzymes and protein interaction domains. Library approaches have become increasingly useful as high-throughput strategies for the analysis of large numbers of new proteins identified as a result of genome-sequencing efforts.
Benjamin E. Turk, Lewis C. Cantley
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Synthetic peptide libraries

1997
Combinatorial chemistry is a rapidly developing field. It is now considered as one of the most important recent advances in medicinal chemistry. In addition to drug lead identification, combinatorial chemistry can also be applied to the optimization of the initial lead.
Kit S. Lam, Zhan-Gong Zhao
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Peptide and Non-Peptide Combinatorial Libraries

2006
The field of combinatorial peptide chemistry was created when the first limited peptide library was synthesized with multipin technology in 1984. Since 1990, the field of combinatorial chemistry has advanced rapidly. It has emerged as a powerful tool in the study of many biological systems. In essence, a combinatorial peptide library (numbering 104–108
Kit S. Lam, Ruiwu Liu
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Chemical synthesis of peptide libraries

Bioorganic & Medicinal Chemistry Letters, 1993
Abstract The efficiency of the “portioning-mixing” method is demonstrated by the synthesis of more than one million hexapeptides in 5 days. An example is described to illustrate the possibility of completion of partial peptide libraries. Our method is also shown to be suitable to carry out binary peptide synthesis. In addition, a new screening method
Árpd́ Furkua, Gábor Dibó, Attila L. Kovács, Ferenc Sebestyén   +3 more
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Peptide libraries: criteria and trends

Trends in Genetics, 1993
The development of approaches for preparing peptide libraries, containing millions of different amino acid sequences of a specified length, provides an invaluable resource for characterizing the molecular interactions that underlie many biological processes.
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Peptide Libraries in Cellular Immune Recognition

1999
Protective immunity against microbial pathogens is connected with the ability to discriminate between self and non-self. Vertebrates have evolved an adaptive immune system in which specialized white blood cells, the T cells, fulfill this role. These cells are trained to recognize proteolytic fragments of viral, bacterial or parasitic antigens in the ...
Robert Tampé, Günther Jung, Stephan Uebel, K. H. Wiesmüller   +3 more
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Peptide and Peptide Library Cyclization via Bromomethylbenzene Derivatives

2014
Cyclization confers several advantages to peptides, cumulatively serving to make them more drug-like. In this protocol, cyclic peptides are generated via bis-alkylation of cysteine-containing peptides using α,α'-dibromo-m-xylene. The reactions are robust and high yielding.
David E. Hacker, Matthew C. T. Hartman, Aruna Anbazhagan, Mohammed Almohaini, Zhong Ma   +4 more
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Generation of bioactive peptides by biological libraries

Journal of Chromatography B, 2008
Biological libraries are powerful tools for discovery of new ligands as well as for identification of cellular interaction partners. Since the first development of the first biological libraries in form of phage displays, numerous biological libraries have been developed.
Alois Jungbauer, Christa Mersich
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Conformational Analysis of Peptide Libraries

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
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Encoded libraries of chemically modified peptides

Current Opinion in Chemical Biology, 2015
The use of powerful technologies for generating and screening DNA-encoded protein libraries has helped drive the development of proteins as pharmaceutical ligands. However the development of peptides as pharmaceutical ligands has been more limited.
Greg Winter, Christian Heinis
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