Results 11 to 20 of about 6,263,550 (261)

Discovery of novel benzylquinazoline molecules as p97/VCP inhibitors

Frontiers in Pharmacology, 2023
Introduction: Protein p97 is an extensively investigated AAA ATPase with various cellular activities, including cell cycle control, ubiquitin–proteasome system, autophagy, and NF-κB activation.Method: In this study, we designed, synthesized and evaluated
Xiaoyi Zhang, Xiaoyi Zhang, Lingna Jiang, Lingna Jiang, Yixin Li, Yixin Li, Qiqi Feng, Qiqi Feng, Xiulin Sun, Xiulin Sun, Yaonan Wang, Ming Zhao, Ming Zhao   +12 more
doaj   +1 more source

Transcription of brain natriuretic peptide and atrial natriuretic peptide genes in human tissues [PDF]

, 1994
We have compared the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) genes in various human tissues using a quantitative polymerase chain reaction technique.
Nguyen, T., Nemer, M., Gerbes, Alexander L., Dagnino, L.   +3 more
core   +2 more sources

Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity

Scientific Reports, 2021
In the emerging era of antimicrobial resistance, the susceptibility to co-infections of patients suffering from either acquired or inherited hemolytic disorders can lead to dramatic increase in mortality rates.
Tünde Juhász, Mayra Quemé-Peña, Bence Kővágó, Judith Mihály, Maria Ricci, Kata Horváti, Szilvia Bősze, Ferenc Zsila, Tamás Beke-Somfai   +8 more
doaj   +1 more source

Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering

Frontiers in Microbiology, 2022
Mutation-driven evolution of novel function on an old gene has been documented in many development- and adaptive immunity-related genes but is poorly understood in immune effector molecules.
Jing Gu, Noriyoshi Isozumi, Bin Gao, Shinya Ohki, Shunyi Zhu   +4 more
doaj   +1 more source

Peptide-directed crystal growth modification in the formation of ZnO [PDF]

, 2015
Biomolecule-mediated synthesis is fascinating in terms of the level of control and the intricate hierarchical structures of the materials that can be produced.
Roe, MJ, Liang, M-K, Sola-Rabada, A, Perry, CC   +3 more
core   +1 more source

p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling

Cell Reports, 2017
Producing the neuronal diversity required to adequately discriminate all elements of somatosensation is a complex task during organogenesis. The mechanisms guiding this process during dorsal root ganglion (DRG) sensory neuron specification remain poorly ...
Zhijiang Chen, Christopher R. Donnelly, Bertha Dominguez, Yoshinobu Harada, Weichun Lin, Alan S. Halim, Tasha G. Bengoechea, Brian A. Pierchala, Kuo-Fen Lee   +8 more
doaj   +1 more source

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide [PDF]

, 2004
Background: Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality.
Ramona Scotl, Hobbs, Adrian, Ahluwalia, Amrita, Foster, Paul, Hobbs, A., Phd Amrita Ahluwalia, Foster, P., Adrian Hobbs, Phd Paul Foster, Scotland, R., Prescott, Craig, Scotland, Ramona, Ahluwalia, A., Phd Craig Prescott, Natriuretic Peptide, Prescott, C.   +15 more
core   +1 more source

A peptide filtering relation quantifies MHC class I peptide optimization [PDF]

, 2011
Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Luca Cardelli, Goldstein, LD, Phillips, Andrew, Emmott, Stephen, Elliott, T, Mark Howarth, Werner, JM, Werner, Joern M., Leonard D. Goldstein, Andrew Phillips, Elliot, Tim, Dalchau, Neil, Goldstein, Leonard D., Cardelli, L, Cardelli, Luca, Tim Elliott, Dalchau, N, Emmott, S, Neil Dalchau, Howarth, M, Elliott, Tim, Leonard D Goldstein, Joern M. Werner, Phillips, A, Joern M Werner, Stephen Emmott, Howarth, Mark   +26 more
core   +1 more source

Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

Exploration, 2022
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing excessively produced reactive oxygen and nitrogen species (RONS) is beneficial
Ji Yang, Ruofei Zhang, Hanqing Zhao, Haifeng Qi, Jingyun Li, Jian‐Feng Li, Xinyao Zhou, Aiqin Wang, Kelong Fan, Xiyun Yan, Tao Zhang   +10 more
doaj   +1 more source

Peptide Materials in Dye Sensitized Solar Cells

Energies, 2022
In September 2015, the ONU approved the Global Agenda for Sustainable Development, by which all countries of the world are mobilized to adopt a set of goals to be achieved by 2030.
Emanuela Gatto, Raffaella Lettieri, Luigi Vesce, Mariano Venanzi   +3 more
doaj   +1 more source