Results 101 to 110 of about 134,053 (282)
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future [PDF]
Arghya Ray, Bengt Nordén
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Microbiome Single Cell Atlases Generated with a Commercial Instrument
Single cell sequencing is valuable for dissecting complex systems and uncovering unique features in individual cell types. However, tools for single cell microbial analysis are limited. Easily Accessible Single microbe sequencing (EASi‐seq), which adapts a commercially available single cell platform for efficient sequencing of single microbial genomes ...
Xiangpeng Li+8 more
wiley +1 more source
Inhibition of telomerase activity by a cell‐penetrating peptide nucleic acid construct in human melanoma cells [PDF]
Raffaella Villa+5 more
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Rational Design of Inner Ear Drug Delivery Systems
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu+5 more
wiley +1 more source
PNA-Pdx: Versatile Peptide Nucleic Acid-Based Detection of Nucleic Acids and SNPs. [PDF]
Jiang W+4 more
europepmc +1 more source
Peptide nucleic acids: versatile tools for gene therapy strategies [PDF]
David A. Dean
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This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.
Shourui Hu+13 more
wiley +1 more source
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi+8 more
wiley +1 more source
DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid. [PDF]
Oyaghire SN+6 more
europepmc +1 more source
Peptide Nucleic Acids: On the Road to New Gene Therapeutic Drugs [PDF]
Peter Nielsen
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