Results 11 to 20 of about 200,834 (306)

Peptide‐Peptide Nucleic Acid Hybrid Hydrogel Based on Sequence Programmable Morphological Change for DNA Data Storage [PDF]

Small Structures
Peptide‐based hydrogels provide biocompatible, stimuli‐responsive platforms, while peptide‐DNA hybrids extend programmability through hybridization‐driven crosslinking. However, nucleobase incorporation can influence peptide self‐assembly pathways.
Huiling Lei, Jinsheng Li, Zixiao Zhang, Zi’an Lin, Guangxu Zhang, Jianjian Huang, Shuhan Dai, Guojiao Wu, Hongmei Liu, Yuzhou Wu   +9 more
doaj   +2 more sources

Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid. [PDF]

Sci Adv
Petkowski JJ, Seager S, Seager MD, Bains W, Marinus N, Poizat M, Plumet C, van Wiltenburg J, Visser T, Poelert M.   +9 more
europepmc   +2 more sources

Peptide Nucleic Acid Microarrays [PDF]

, 2004
A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette, Jacob, Ole, Brandt, Achim, Stephan, Jörg D, Hoheisel   +3 more
openaire   +2 more sources

Peptide Nucleic Acid – An Opportunity for Bio-Nanotechnology

CHIMIA, 2014
DNA is a major player in the field of bio-nanotechnology and many interesting applications have been realized using this oligonucleotide. In contrast, the use of peptide nucleic acid (PNA), which is a non-natural, neutral analogue of DNA with ...
Philipp Anstaett, Gilles Gasser
doaj   +1 more source

Peptide Nucleic Acids: Applications in Biomedical Sciences

Molecules, 2020
The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
doaj   +1 more source

Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer

Cancer Medicine, 2021
Background Bronchoscopy is a minimally invasive procedure for establishing the diagnosis of lung cancer. It sometimes fails to obtain tissue samples but readily collects cytological samples.
Kazutaka Fujita, Masayuki Nakayama, Masafumi Sata, Yoshiaki Nagai, Shu Hisata, Naoko Mato, Takuji Suzuki, Masashi Bando, Nobuyuki Hizawa, Koichi Hagiwara   +9 more
doaj   +1 more source

Chemistry of Peptide-Oligonucleotide Conjugates: A Review

Molecules, 2021
Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova, Alesya Fokina, Dmitry Stetsenko   +2 more
doaj   +1 more source

Peptide-nucleic acid nanostructures for transfection

Biomolecular Concepts, 2012
To use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers.
Bechinger Burkhard
doaj   +1 more source

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

Veterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi, Arvind Kumar Singh, Kantaraja Chindera, Manish V. Bais, Ashok Kumar Tiwari, Satish Kumar   +5 more
doaj   +1 more source

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source