Results 11 to 20 of about 765,071 (332)

Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery

Biomedicines, 2021
Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a patient.
Prisca Boisguérin, Karidia Konate, Emilie Josse, Eric Vivès, Sébastien Deshayes   +4 more
doaj   +2 more sources

Peptide Nucleic Acid-Based Biosensors for Cancer Diagnosis

Molecules, 2017
The monitoring of DNA and RNA biomarkers freely circulating in the blood constitutes the basis of innovative cancer detection methods based on liquid biopsy.
Roberta D’Agata, Maria Chiara Giuffrida, Giuseppe Spoto   +2 more
doaj   +2 more sources

Potential applications of peptide nucleic acid in biomedical domain

Engineering Reports, 2020
Peptide Nucleic Acid (PNA) are DNA/RNA synthetic analogs with 2‐([2‐aminoethyl] amino) acetic acid backbone. They partake unique antisense and antigene properties, just due to its inhibitory effect on transcription and translation; they also undergo ...
Kshitij RB Singh, Parikipandla Sridevi, Ravindra Pratap Singh   +2 more
doaj   +2 more sources

Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures

Nature Communications, 2020
Nucleic acid-based materials are usually only compatible with aqueous solutions. Here, the authors show a structural nucleic acid nanotechnology using gamma-modified peptide nucleic acids that enables formation of solvent-compatible, self-assembling ...
Sriram Kumar, Alexander Pearse, Ying Liu, Rebecca E. Taylor   +3 more
doaj   +2 more sources

Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide

Molecular Therapy: Nucleic Acids, 2016
Staphylococcus aureus infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibiotics.
Mostafa FN Abushahba, Haroon Mohammad, Mohamed N Seleem   +2 more
doaj   +2 more sources

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid

Nature Communications, 2019
DNA is an attractive nanomaterial, yet limited compared to polyamides due to low stability and mechanical issues. Here, the authors combine polyamide and DNA characteristics to form mechanically rigid self-assembled peptide nucleic acid based materials ...
Vasantha Basavalingappa, Santu Bera, Bin Xue, Ido Azuri, Yiming Tang, Kai Tao, Linda J. W. Shimon, Michael R. Sawaya, Sofiya Kolusheva, David S. Eisenberg, Leeor Kronik, Yi Cao, Guanghong Wei, Ehud Gazit   +13 more
doaj   +2 more sources

Evaluation of Peptide Nucleic Acid Encapsulation in Ferritin Nanocages for Gene Silencing Applications. [PDF]

Biomacromolecules
Falanga AP, Farina MV, Cianfoni G, Barolo L, Di Meo C, Borsatti GE, Ghirga F, Botta B, Pisano L, Borbone N, D'Errico S, Paone A, Oliviero G, Quaglio D, Baiocco P.   +14 more
europepmc   +2 more sources

Polyanion order controls liquid-to-solid phase transition in peptide/nucleic acid co-assembly. [PDF]

Front Mol Biosci, 2022
Gordon-Kim C, Rha A, Poppitz GA, Smith-Carpenter J, Luu R, Roberson AB, Conklin R, Blake A, Lynn DG.   +8 more
europepmc   +2 more sources

The challenge of peptide nucleic acid synthesis.

Chemical Society Reviews, 2023
Peptide nucleic acids (PNAs) are an important class of DNA/RNA mimics that can hybridize complementary chains of nucleic acids with high affinity and specificity.
K. Nandhini, D. Shaer, F. Albericio, B. G. de la Torre   +3 more
semanticscholar   +1 more source

Non-transgenic Gene Modulation via Spray Delivery of Nucleic Acid/Peptide Complexes into Plant Nuclei and Chloroplasts

ACS Nano, 2022
Genetic engineering of economically important traits in plants is an effective way to improve global welfare. However, introducing foreign DNA molecules into plant genomes to create genetically engineered plants not only requires a lengthy testing period
Chonprakun Thagun, Yoko Horii, Maai Mori, Seiya Fujita, M. Ohtani, K. Tsuchiya, Y. Kodama, Masaki Odahara, K. Numata   +8 more
semanticscholar   +1 more source