Results 11 to 20 of about 134,053 (282)
Investigation of the Characteristics of NLS-PNA: Influence of NLS Location on Invasion Efficiency
Applied Sciences, 2020 Peptide nucleic acid can recognise sequences in double-stranded DNA (dsDNA) through the formation of a double-duplex invasion complex. This double-duplex invasion is a promising method for the recognition of dsDNA in cellula because peptide nucleic acid (
Yuichiro Aiba +3 more
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Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery
Biomedicines, 2021 Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a patient.
Prisca Boisguérin +4 more
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Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Nature Communications, 2020 Nucleic acid-based materials are usually only compatible with aqueous solutions. Here, the authors show a structural nucleic acid nanotechnology using gamma-modified peptide nucleic acids that enables formation of solvent-compatible, self-assembling ...
Sriram Kumar +3 more
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Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
Pharmaceutics, 2020 In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process.
Yanfang Wang, Ernst Wagner
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Peptide nucleic acids in materials science [PDF]
Artificial DNA: PNA & XNA, 2012 This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels ...
D. Bonifazi +3 more
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A self-replicating peptide nucleic acid [PDF]
Org. Biomol. Chem., 2014 This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
Günter von Kiedrowski +1 more
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Peptide Nucleic Acids: Applications in Biomedical Sciences
Molecules, 2020 The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
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Highly sensitive detection of driver mutations from cytological samples and cfDNA in lung cancer
Cancer Medicine, 2021 Background Bronchoscopy is a minimally invasive procedure for establishing the diagnosis of lung cancer. It sometimes fails to obtain tissue samples but readily collects cytological samples.
Kazutaka Fujita +9 more
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Chemistry of Peptide-Oligonucleotide Conjugates: A Review
Molecules, 2021 Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability, and, thus, overall efficiency of therapeutic nucleic acids, such as ...
Kristina Klabenkova +2 more
doaj +1 more source
Peptides for nucleic acid delivery
Advanced Drug Delivery Reviews, 2016 Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene therapeutic compounds which hold enormous clinical potential. Despite their undoubted potential, clinical translation of these molecules, however, has been largely held back by their limited bioavailability in the target tissues/cells.
Kariem Ezzat +4 more
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