Results 11 to 20 of about 189,505 (303)
Peptide-nucleic acid nanostructures for transfection [PDF]
Biomolecular Concepts, 2012 To use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers.
Bechinger Burkhard
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Peptide Nucleic Acid Microarrays [PDF]
, 2004 A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette Jacob +3 more
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An Introduction to Peptide Nucleic Acid [PDF]
Current Issues in Molecular Biology, 1999 Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular ...
Nielsen, P E, Egholm, M
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Peptide-Based Nanoparticles for Therapeutic Nucleic Acid Delivery
Biomedicines, 2021 Gene therapy offers the possibility to skip, repair, or silence faulty genes or to stimulate the immune system to fight against disease by delivering therapeutic nucleic acids (NAs) to a patient.
Prisca Boisguérin +4 more
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Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Nature Communications, 2020 Nucleic acid-based materials are usually only compatible with aqueous solutions. Here, the authors show a structural nucleic acid nanotechnology using gamma-modified peptide nucleic acids that enables formation of solvent-compatible, self-assembling ...
Sriram Kumar +3 more
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Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
Pharmaceutics, 2020 In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process.
Yanfang Wang, Ernst Wagner
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Biomolecules, 2023 The use of template molecules as chemical scaffolds that significantly influence the course of the reaction has recently been intensively studied. Peptide nucleic acids (PNA) are molecules that mimic natural nucleic acids.
Mateusz Waliczek +4 more
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Tailoring the Structure of Cell Penetrating DNA and RNA Binding Nucleopeptides [PDF]
, 2022 Synthetic nucleic acid interactors represent an exciting research field due to their biotechnological and potential therapeutic applications. The translation of these molecules into drugs is a long and difficult process that justifies the continuous ...
Alessandra Del Bene +14 more
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Peptide nucleic acids in materials science [PDF]
Artificial DNA: PNA & XNA, 2012 This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels ...
D. Bonifazi +3 more
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Breathing Life into Polycations [PDF]
, 2008 The lack of efficient delivery systems is still limiting the full therapeutic potential of siRNA. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied.
Meyer, Martin +4 more
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