Results 231 to 240 of about 765,071 (332)

Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity. [PDF]

Nucleic Acid Ther
Carufe KEW, Economos NG, Glazer PM.
europepmc   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

Luminescent Iridium-Peptide Nucleic Acid Bioconjugate as Photosensitizer for Singlet Oxygen Production toward a Potential Dual Therapeutic Agent. [PDF]

Inorg Chem
Dell'Acqua RM, Schifano V, Dozzi MV, D'Alfonso L, Panigati M, Rusmini P, Piccolella M, Poletti A, Cauteruccio S, Maggioni D.   +9 more
europepmc   +1 more source

Exclusion of Anchor-Matched Peptide Nucleic Acid from Liquid-Ordered Domains by Hybridization with Complementary Flavin-Labeled DNA. [PDF]

ACS Omega, 2023
Oka Y.
europepmc   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Peptide nucleic acid-immobilised paper combined with multiplex recombinase polymerase amplification for the ultrasensitive and rapid detection of rifampicin-resistant tuberculosis. [PDF]

Sci Rep
Jirakittiwut N, Sathianpitayakul P, Santanirand P, Akeda Y, Vilaivan T, Ratthawongjirakul P.   +5 more
europepmc   +1 more source

Nanomechanical assay for ultrasensitive and rapid detection of SARS-CoV-2 based on peptide nucleic acid. [PDF]

Nano Res, 2023
Wang Y, Yan T, Mei K, Rao D, Wu W, Chen Y, Peng Y, Wang J, Wu S, Zhang Q.   +9 more
europepmc   +1 more source

Programmable Hydrogels: Frontiers in Dynamic Closed‐Loop Systems, Biomimetic Synergy, and Clinical Translation

Advanced Science, EarlyView.
This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang, Bohan Yin, Behzad Shiroud Heidari, George Youssef, Monika Gosecka, Mateusz Gosecki, Fernando G. Torres, Siu Hong Dexter Wong, Jagan Mohan Dodda   +8 more
wiley   +1 more source

Investigating Bacterial Vaginosis Pathogenesis Using Peptide Nucleic Acid-Fluorescence <i>In Situ</i> Hybridization With a Focus on the Roles of <i>Gardnerella</i> Species, <i>Prevotella bivia</i>, and <i>Fannyhessea vaginae</i>. [PDF]

Open Forum Infect Dis
George SD, Amerson-Brown MH, Sousa LGV, Carter TM, Rinehart AH, Riegler AN, Leal SM, Aaron KJ, Hao J, Tamhane A, Dong C, Lammons JW, Elnaggar JH, Graves KJ, Łaniewski P, Herbst-Kralovetz MM, Taylor CM, Cerca N, Muzny CA.   +18 more
europepmc   +1 more source

Characteristics and prognostic analysis of patients with detected KRAS mutations in resected lung adenocarcinomas by peptide nucleic acid-locked nucleic acid polymerase chain reaction (PNA-LNA PCR) clamp method. [PDF]

Transl Lung Cancer Res, 2023
Hashimoto T, Owada Y, Katagiri H, Yakuwa K, Tyo K, Sugai M, Fuzimura I, Utsumi Y, Akiyama M, Nagashima H, Terasaki H, Yanagawa N, Saito H, Sugai T, Maemondo M.   +14 more
europepmc   +1 more source