Results 231 to 240 of about 134,053 (282)
Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges
Advanced NanoBiomed Research, EarlyView.Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou +7 more
wiley +1 more source
Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof
Angewandte Chemie, EarlyView.PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim +8 more
wiley +2 more sources
Emerging Strategies for Platelet‐Modified Nanoparticles in Targeted Tumor Therapy
Advanced NanoBiomed Research, EarlyView.This review highlights innovative strategies using platelet‐modified nanoparticles to target tumors more precisely. By mimicking platelet functions, these biomimetic carriers improve tumor homing, enhance drug delivery, and reduce immune clearance.
Chunyu Bai +5 more
wiley +1 more source
Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers
Angewandte Chemie, EarlyView.We developed a nanopore‐based biosensor for single‐molecule protein profiling using aptamer‐modified DNA carrier dimerization strategy, enabling selective and ultrasensitive detection of proteins and protein complexes. This approach promises advances in early‐stage clinical diagnostics and precision medicine.
Xiaoyi Wang +4 more
wiley +2 more sources
Decoy DNA Protects Molecular Tension Probes from DNase Degradation
Angewandte Chemie, EarlyView.DNA‐based probes are rapidly degraded by DNases in live‐cell environments, limiting their use. We introduce a decoy DNA strategy, where an excess of unmodified double‐stranded DNA acts as a competitive substrate for DNases, protecting functional DNA probes and significantly extending their stability for long‐term live‐cell studies.
Hongyuan Zhang +2 more
wiley +2 more sources
Eine Schnittstelle zwischen B‐DNA und DNA‐Mimikry‐Foldameren
Angewandte Chemie, EarlyView.Helikale aromatische Oligoamid‐DNA‐Mimikry‐Foldamere, die die Form und Ladungsverteilung von B‐DNA‐Duplexen reproduzieren, wurden mit Hilfe eines neuen Linkers, der sowohl als DNA‐Haarnadel als auch als aromatische Oligoamid‐Einheit dient, mit DNA‐Duplexen verknüpft.
Manuel Loos +10 more
wiley +1 more source
Synthesis of Versatile DNA‐Conjugated Aldehydes by Controlled Oxidation of Amines
Angewandte Chemie, EarlyView.A controlled oxidation strategy enables efficient in situ generation of aldehyde‐functionalized DNAs from DNA‐conjugated amines using O2/laccase/TEMPO. This approach facilitates reversible amine–aldehyde transformations for DNA bioconjugation, and provides access to chemically diverse DNA‐encoded libraries, broadening the toolbox for chemical biology ...
Guixian Zhao +6 more
wiley +2 more sources
Synthesis of Chirally Chimeric Protein Nanoparticle Vaccines via Mirror‐Image Spy Chemistry
Angewandte Chemie, EarlyView.This study illustrates a versatile strategy for creating chirally chimeric protein constructs by merging natural‐chirality (L‐) and mirror‐image (D‐) protein motifs through a combination of L‐sortase‐mediated transpeptidation and D‐SpyStapler‐mediated ligation.
Songzi Kou +4 more
wiley +2 more sources
Automated Fast-Flow Synthesis of Peptide Nucleic Acid Conjugates
, 2021 Li C +11 more
europepmc +1 more source