Results 21 to 30 of about 773,975 (378)

Investigation of the Characteristics of NLS-PNA: Influence of NLS Location on Invasion Efficiency

Applied Sciences, 2020
Peptide nucleic acid can recognise sequences in double-stranded DNA (dsDNA) through the formation of a double-duplex invasion complex. This double-duplex invasion is a promising method for the recognition of dsDNA in cellula because peptide nucleic acid (
Yuichiro Aiba, Gerardo Urbina, Masanari Shibata, Osami Shoji   +3 more
doaj   +1 more source

Acid-base and lipophilic properties of peptide nucleic acid derivatives

Journal of Pharmaceutical Analysis, 2021
The first combined experimental and theoretical study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives, including eleven PNA monomers and two PNA decamers, is described.
Pramod Thakare, Francesca Vasile, Maura Vallaro, Sonja Visentin, Giulia Caron, Emanuela Licandro, Silvia Cauteruccio   +6 more
doaj   +1 more source

Sequence-Specific Recognition of Double-Stranded DNA by Peptide Nucleic Acid Forming Double-Duplex Invasion Complex

Applied Sciences, 2022
Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone.
Yuichiro Aiba, Masanari Shibata, Osami Shoji   +2 more
doaj   +1 more source

Exploiting double exchange Diels-Alder cycloadditions for immobilization of peptide nucleic acids on gold nanoparticles [PDF]

, 2020
The generation of PNA-decorated gold nanoparticles (AuNPs) has revealed to be more difficult as compared to the generation of DNA-functionalized ones. The less polar nature of this artificial nucleic acid system and the associated tendency of the neutral
Cadoni, Enrico, Madder, Annemieke, Mancin, Fabrizio, Manicardi, Alex, Rosa-Gastaldo, Daniele   +4 more
core   +2 more sources

A Self-Replicating Peptide Nucleic Acid [PDF]

Org. Biomol. Chem., 2011
This paper presents evidence for self-replication in a most basic PNA molecular network and provides an explanation for the underlying kinetics.
Tobias A. Plöger, Günter von Kiedrowski   +1 more
openalex   +5 more sources

Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization

Pharmaceutics, 2020
In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process.
Yanfang Wang, Ernst Wagner
doaj   +1 more source

Peptide Nucleic Acid Microarrays [PDF]

, 2004
A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette, Jacob, Ole, Brandt, Achim, Stephan, Jörg D, Hoheisel   +3 more
openaire   +2 more sources

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Troiber, Christina, Wagner, Ernst
core   +1 more source

Multiplex Paper-Based Colorimetric DNA Sensor Using Pyrrolidinyl Peptide Nucleic Acid-Induced AgNPs Aggregation for Detecting MERS-CoV, MTB, and HPV Oligonucleotides

Analytical Chemistry, 2017
The development of simple fluorescent and colorimetric assays that enable point-of-care DNA and RNA detection has been a topic of significant research because of the utility of such assays in resource limited settings.
Prinjaporn Teengam, W. Siangproh, A. Tuantranont, T. Vilaivan, O. Chailapakul, C. Henry   +5 more
semanticscholar   +1 more source

Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting. [PDF]

ACS Pharmacol Transl Sci
Affibody-mediated PNA-based pretargeting shows promise for HER2-expressing tumor radiotherapy. In our recent study, a 15-mer ZHER2:342-HP15 affibody-PNA conjugate, in combination with a shorter 9-mer [177Lu]Lu-HP16 effector probe, emerged as the most effective pretargeting strategy.
Westerlund K, Oroujeni M, Gestin M, Clinton J, Hani Rosly A, Tano H, Vorobyeva A, Orlova A, Eriksson Karlström A, Tolmachev V.   +9 more
europepmc   +4 more sources