Results 21 to 30 of about 134,053 (282)

Peptide Nucleic Acid – An Opportunity for Bio-Nanotechnology

CHIMIA, 2014
DNA is a major player in the field of bio-nanotechnology and many interesting applications have been realized using this oligonucleotide. In contrast, the use of peptide nucleic acid (PNA), which is a non-natural, neutral analogue of DNA with ...
Philipp Anstaett, Gilles Gasser
doaj   +1 more source

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

Veterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi, Arvind Kumar Singh, Kantaraja Chindera, Manish V. Bais, Ashok Kumar Tiwari, Satish Kumar   +5 more
doaj   +1 more source

Dynamic changes of differential metabolites and key metabolic pathways of Gastrodia elata Blume during fermentation

International Journal of Food Properties, 2022
The fermentation of Gastrodia elata Blume (GEB) is an extremely complex process, and abundant metabolites are produced, which have a great influence on the quality and flavor.
Yu Wang, Ling Lin, Lilang Li, Qiji Li, Ming Gao, Xiaosheng Yang, Juan Yang, Chunzhi Xie   +7 more
doaj   +1 more source

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

A Convenient Asymmetric Synthesis of a β-amino Ester with Additional Functionalization as a Precursor for Peptide Nucleic Acid (PNA) Monomers

Molecules, 2006
We report the asymmetric synthesis of di-3-pentyl (3S,αS,7E)-3-N-benzyl-N- α-methylbenzylamino-dec-7-enedioate (9), which contains the correct functionalization to produce δ-amino acid derivatives to be used as monomers for Peptide Nucleic Acid (
Julio G. Urones, Mercedes García, M. Rosa Sánchez, Sara H. Domínguez, David Díez, Narciso M. Garrido   +5 more
doaj   +1 more source

Modification of the Linker Amino Acid in the Cell-Penetrating Peptide NickFect55 Leads to Enhanced pDNA Transfection for In Vivo Applications

Pharmaceutics, 2023
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors.
Heleri H. Härk, Ly Porosk, Lucas R. de Mello, Piret Arukuusk, Emerson R. da Silva, Kaido Kurrikoff   +5 more
doaj   +1 more source

Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice. [PDF]

PLoS ONE, 2010
BACKGROUND: A peptide able to transduce cardiac tissue specifically, delivering cargoes to the heart, would be of significant therapeutic potential for delivery of small molecules, proteins and nucleic acids.
Maliha Zahid, Brett E Phillips, Sean M Albers, Nick Giannoukakis, Simon C Watkins, Paul D Robbins   +5 more
doaj   +1 more source

Quantifying telomeric lncRNAs using PNA-labelled RNA-Flow FISH (RNA-Flow)

Communications Biology, 2022
Telomeric-associated long non-coding RNAs TERRA and TERC can be quantified in culture cell lines and human PBMCs using peptide nucleic acid probes with flow cytometry (RNA-Flow).
Iria González-Vasconcellos, María A. Cobos-Fernández, Michael J. Atkinson, José Fernandez-Piqueras, Javier Santos   +4 more
doaj   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

Synthesis and Purification of Peptide Nucleic Acids [PDF]

Current Protocols in Nucleic Acid Chemistry, 2002
AbstractPeptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A., Nulf, Christopher J., Corey, David R.   +2 more
openaire   +4 more sources