Results 51 to 60 of about 773,975 (378)

Modification of the Linker Amino Acid in the Cell-Penetrating Peptide NickFect55 Leads to Enhanced pDNA Transfection for In Vivo Applications

Pharmaceutics, 2023
Despite numerous efforts over the last three decades, nucleic acid-based therapeutics still lack delivery platforms in the clinical stage. Cell-penetrating peptides (CPPs) may offer solutions as potential delivery vectors.
Heleri H. Härk, Ly Porosk, Lucas R. de Mello, Piret Arukuusk, Emerson R. da Silva, Kaido Kurrikoff   +5 more
doaj   +1 more source

Reprogramming the assembly of unmodified DNA with a small molecule [PDF]

, 2016
The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA ‘alphabet’ by synthetic incorporation of new bases can introduce new functionalities and enable the ...
A Chworos, A Rich, AK Ogawa, AM Pyle, Andrea A. Greschner, Anne Petitjean, B Roy, BJ Cafferty, C Geary, C Hao, Christopher J. Serpell, D Jiang, D Shin, DA Malyshev, DC Di Giammartino, E Largy, E Meggers, FA Aldaye, Faisal Aldaye, GM Whitesides, H Chen, H Yang, Hanadi F. Sleiman, HZ Yang, J Choi, JA Piccirilli, JA Zerkowski, JC Chaput, JD Watson, KS Park, L Weill, M Egholm, M Egholm, M Kimoto, M Ma, M Martin-Ortiz, M Polak, M Shionoya, M Winnacker, M-Y Pan, MC Chen, N Berova, N Safaee, Nicole Avakyan, OP Çetinkol, RJ Davies, RJ Davies, S Balasubramanian, S Chakraborty, S Woo, SS Jain, TF De Greef, Violeta Toader, Y Krishnan, Y Zeng, YN Teo, YQ Wu, Z Yang, Ö Persil   +58 more
core   +1 more source

Quantifying telomeric lncRNAs using PNA-labelled RNA-Flow FISH (RNA-Flow)

Communications Biology, 2022
Telomeric-associated long non-coding RNAs TERRA and TERC can be quantified in culture cell lines and human PBMCs using peptide nucleic acid probes with flow cytometry (RNA-Flow).
Iria González-Vasconcellos, María A. Cobos-Fernández, Michael J. Atkinson, José Fernandez-Piqueras, Javier Santos   +4 more
doaj   +1 more source

New amphiphilic amino acid derivatives for efficient DNA transfection in vitro [PDF]

, 2017
Nucleic acids-based therapies have recently developed as next-generationagents for treating and preventing viral infection, cancer, and genetic disorders,but their use is still limited due to its relatively poor delivery into targetedcells.
Antuña, Sebastián, Argarañá, María Fernanda, de Zan, María Mercedes, Giorello, Antonella, Muller, Diana, Peña, Lucía Carolina, Prieto, Claudio, Veaute, Carolina Melania Isabel   +7 more
core   +1 more source

Peptide nucleic acid–nanodiamonds: covalent and stable conjugates for DNA targeting

, 2013
Claire Rogel Gaillard, Hugues A. Girard, Caroline Falck, Vincent Paget, Vesna Šimić, Nicolas Ugolin, P. Bergonzo, Sylvie Chevillard, Jean Charles Arnault   +8 more
openalex   +3 more sources

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 [PDF]

, 2010
TopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR-ATRIP checkpoint kinase complex.
Adams, Ali, Antony W. Oliver, Bermudez, Berrow, Boner, Bork, Botuyan, Callebaut, CCP4, Chen, Clapperton, Delacroix, Dore, Dulic, Emsley, Fenech, Furuya, Garcia, Glover, Gong, Greer, Herold, Kilkenny, Krishnan, Kumagai, Laurence H. Pearl, Lee, Lee, Lehmann, Leslie, Leung, Linding, Liu, Liu, Lloyd, Majka, Manke, Mathieu Rappas, McCoy, Mochida, Mordes, Mordes, Navadgi-Patil, Navadgi-Patil, Saka, Schmidt, Sheldrick, Shiozaki, Smits, Sohn, St Onge, St Onge, Stucki, Takeishi, Terwilliger, Varma, Vonrhein, Wang, Watts, Williams, Wollmann, Xu, Yamane, Yan, Yoo, Yu, Zeng, Zhang, Zou   +69 more
core   +2 more sources

Recent advances in peptide nucleic acid for cancer bionanotechnology

Acta Pharmacologica Sinica, 2017
Peptide nucleic acid (PNA) is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to ...
Jun Wu, Q. Meng, Hong-mei Ren, Hong-tao Wang, Jie Wu, Qi Wang   +5 more
semanticscholar   +1 more source

Trypsin inhibition by macrocyclic and open-chain variants of the squash inhibitor MCoTI-II [PDF]

, 2005
MCoTl-I and MCoTl-II from the seeds of Momordica cochinchinensis are inhibitors of trypsin-like proteases and the only known members of the large family of squash inhibitors that are cyclic and contain an additional loop connecting the amino- and the ...
Avrutina, Olga, Diederichsen, Ulf, Gabrijelcic-Geiger, Dusica, Kolmar, Harald, Le Nguyen, Dung, Schmoldt, Hans-Ulrich, Sommerhoff, Christian P.   +6 more
core   +1 more source

Peptide nucleic acids in materials science [PDF]

Artificial DNA: PNA & XNA, 2012
This review highlights the recent methods to prepare PNA-based materials through a combination of self-assembly and self-organization processes. The use of these methods allows easy and versatile preparation of structured hybrid materials showing specific recognition properties and unique physicochemical properties at the nano- and micro-scale levels ...
D. Bonifazi, * L.-E. Carloni, V. Corvaglia, A. Delforge   +3 more
openaire   +3 more sources

Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support

BMC Biotechnology, 2005
Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario, Picard François J, Boissinot Maurice, Bissonnette Luc, Peytavi Régis, Ho Hoang-Anh, Raymond Frédéric R, Bergeron Michel G   +7 more
doaj   +1 more source