Results 51 to 60 of about 344,433 (343)

Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase. [PDF]

, 2019
Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and ...
Cui, Xianshu, Dowdy, Steven F, Huggins, Ian J, Jadhav, Satish, Medina, Carlos A, Springer, Aaron D, van den Berg, Arjen   +6 more
core   +1 more source

Synthesis and Biological Properties of Caffeic Acid-PNA Dimers Containing Guanine

Molecules, 2013
Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is endowed with high antioxidant activity. CA derivatives (such as amides) have gained a lot of attention due to their antioxidative, antitumor and antimicrobial properties as well as stable characteristics ...
Antonio Fiorentino, Luigi Russo, Brigida D'Abrosca, Valeria Severino, Severina Pacifico, Gaetano Malgieri, Maria Gaglione, Anna Messere   +7 more
doaj   +1 more source

Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]

, 2007
Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M., Missailidis, Sotiris   +1 more
core   +3 more sources

Therapy of cancer by insect cells containing recombinant baculovirus encoding genes [PDF]

, 2002
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that ...
Dhong, Zhongyun, Fidler, Isaiah J., Lu, Weixin   +2 more
core   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide

Molecular Therapy: Nucleic Acids, 2016
Staphylococcus aureus infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibiotics.
Mostafa FN Abushahba, Haroon Mohammad, Mohamed N Seleem   +2 more
doaj   +1 more source

Reprogramming the assembly of unmodified DNA with a small molecule [PDF]

, 2016
The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA ‘alphabet’ by synthetic incorporation of new bases can introduce new functionalities and enable the ...
A Chworos, A Rich, AK Ogawa, AM Pyle, Andrea A. Greschner, Anne Petitjean, B Roy, BJ Cafferty, C Geary, C Hao, Christopher J. Serpell, D Jiang, D Shin, DA Malyshev, DC Di Giammartino, E Largy, E Meggers, FA Aldaye, Faisal Aldaye, GM Whitesides, H Chen, H Yang, Hanadi F. Sleiman, HZ Yang, J Choi, JA Piccirilli, JA Zerkowski, JC Chaput, JD Watson, KS Park, L Weill, M Egholm, M Egholm, M Kimoto, M Ma, M Martin-Ortiz, M Polak, M Shionoya, M Winnacker, M-Y Pan, MC Chen, N Berova, N Safaee, Nicole Avakyan, OP Çetinkol, RJ Davies, RJ Davies, S Balasubramanian, S Chakraborty, S Woo, SS Jain, TF De Greef, Violeta Toader, Y Krishnan, Y Zeng, YN Teo, YQ Wu, Z Yang, Ö Persil   +58 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

LipoParticles: Lipid-Coated PLA Nanoparticles Enhanced In Vitro mRNA Transfection Compared to Liposomes

Pharmaceutics, 2021
The approval of two mRNA vaccines as urgent prophylactic treatments against Covid-19 made them a realistic alternative to conventional vaccination methods.
Camille Ayad, Pierre Libeau, Céline Lacroix-Gimon, Catherine Ladavière, Bernard Verrier   +4 more
doaj   +1 more source