Therapeutic and diagnostic applications of antisense peptide nucleic acids [PDF]
Molecular Therapy: Nucleic Acids, 2023 Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
Victoria MacLelland +2 more
doaj +3 more sources
Peptide Nucleic Acids Promise New Therapeutics and Gene Editing Tools [PDF]
ACS Central Science, 2023 DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast for millennia.
Rachel Brazil
doaj +3 more sources
Antibacterial Peptide Nucleic Acids—Facts and Perspectives [PDF]
Molecules, 2020 Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Monika Wojciechowska +4 more
doaj +3 more sources
Multifunctional Delivery Systems for Peptide Nucleic Acids [PDF]
Pharmaceuticals, 2020 The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have
Stefano Volpi +3 more
doaj +3 more sources
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) [PDF]
Ultrasonics Sonochemistry, 2023 Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS).
Alessandra Del Bene +9 more
doaj +2 more sources
Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Nature Communications, 2020 Nucleic acid-based materials are usually only compatible with aqueous solutions. Here, the authors show a structural nucleic acid nanotechnology using gamma-modified peptide nucleic acids that enables formation of solvent-compatible, self-assembling ...
Sriram Kumar +3 more
doaj +2 more sources
Potential of Peptide Nucleic Acids in Future Therapeutic Applications [PDF]
Advanced Pharmaceutical Bulletin, 2018 Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker.
Soheila Montazersaheb +2 more
doaj +2 more sources
Subtractive modification of bacterial consortium using antisense peptide nucleic acids [PDF]
Frontiers in Microbiology, 2023 Microbiome engineering is an emerging research field that aims to design an artificial microbiome and modulate its function. In particular, subtractive modification of the microbiome allows us to create an artificial microbiome without the microorganism ...
Tatsuya Hizume +6 more
doaj +2 more sources
Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae [PDF]
Microbiology Spectrum, 2022 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Gina Barkowsky +7 more
doaj +2 more sources
Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids [PDF]
Molecular Therapy: Nucleic Acids, 2021 Peptide nucleic acids (PNAs), a synthetic DNA mimic, have been extensively utilized for antisense- and antigene-based biomedical applications. Significant efforts have been made to increase the cellular uptake of PNAs, but here we examined relatively ...
Shipra Malik +2 more
doaj +2 more sources