Antibacterial Peptide Nucleic Acids—Facts and Perspectives [PDF]
Molecules, 2020 Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Monika Wojciechowska +4 more
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Multifunctional Delivery Systems for Peptide Nucleic Acids [PDF]
Pharmaceuticals, 2020 The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have
Stefano Volpi +3 more
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Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support [PDF]
BMC Biotechnology, 2005 Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario +7 more
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Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) [PDF]
Ultrasonics Sonochemistry, 2023 Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS).
Alessandra Del Bene +9 more
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Subtractive modification of bacterial consortium using antisense peptide nucleic acids [PDF]
Frontiers in Microbiology, 2023 Microbiome engineering is an emerging research field that aims to design an artificial microbiome and modulate its function. In particular, subtractive modification of the microbiome allows us to create an artificial microbiome without the microorganism ...
Tatsuya Hizume +6 more
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Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids [PDF]
Molecules, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris +3 more
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Features of “All LNA” Duplexes Showing a New Type of Nucleic Acid Geometry [PDF]
Journal of Nucleic Acids, 2012 “Locked nucleic acids” (LNAs) belong to the backbone-modified nucleic acid family. The 2′-O,4′-C-methylene-β-D-ribofuranose nucleotides are used for single or multiple substitutions in RNA molecules and thereby introduce enhanced bio- and thermostability.
Charlotte Förster +6 more
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Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae [PDF]
Microbiology Spectrum, 2022 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Gina Barkowsky +7 more
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Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs [PDF]
Journal of Nucleic Acids, 2011 Conformationally preorganized peptide nucleic acids (PNAs) have been synthesized through backbone modifications at the γ-position, where R = alanine, valine, isoleucine, and phenylalanine side chains. The effects of these side-chains on the conformations
Matthew J. Crawford +4 more
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Peptide Nucleic Acids: Applications in Biomedical Sciences [PDF]
Molecules, 2020 The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
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