Multifunctional Delivery Systems for Peptide Nucleic Acids. [PDF]
Pharmaceuticals (Basel), 2020 The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have
Volpi S +3 more
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Antibacterial Peptide Nucleic Acids-Facts and Perspectives. [PDF]
Molecules, 2020 Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Wojciechowska M +4 more
europepmc +3 more sources
Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids [PDF]
Molecules, 2015 This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris +3 more
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Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS). [PDF]
Ultrason Sonochem, 2023 Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS).
Del Bene A +9 more
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Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Nature Communications, 2020 Nucleic acid-based materials are usually only compatible with aqueous solutions. Here, the authors show a structural nucleic acid nanotechnology using gamma-modified peptide nucleic acids that enables formation of solvent-compatible, self-assembling ...
Sriram Kumar +3 more
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Potential of Peptide Nucleic Acids in Future Therapeutic Applications [PDF]
Advanced Pharmaceutical Bulletin, 2018 Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker.
Soheila Montazersaheb +2 more
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Subtractive modification of bacterial consortium using antisense peptide nucleic acids. [PDF]
Front Microbiol, 2023 Microbiome engineering is an emerging research field that aims to design an artificial microbiome and modulate its function. In particular, subtractive modification of the microbiome allows us to create an artificial microbiome without the microorganism ...
Hizume T +4 more
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Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae. [PDF]
Microbiol Spectr, 2022 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Barkowsky G +7 more
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Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
Molecules, 2020 Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.
Nicholas G. Economos +5 more
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Peptide Nucleic Acids: Applications in Biomedical Sciences. [PDF]
Molecules, 2020 The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Yavin E.
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