Multifunctional Delivery Systems for Peptide Nucleic Acids [PDF]
Pharmaceuticals, 2020 The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have
Stefano Volpi +3 more
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Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) [PDF]
Ultrasonics Sonochemistry, 2023 Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS).
Alessandra Del Bene +9 more
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Subtractive modification of bacterial consortium using antisense peptide nucleic acids [PDF]
Frontiers in Microbiology, 2023 Microbiome engineering is an emerging research field that aims to design an artificial microbiome and modulate its function. In particular, subtractive modification of the microbiome allows us to create an artificial microbiome without the microorganism ...
Tatsuya Hizume +6 more
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Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae [PDF]
Microbiology Spectrum, 2022 Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Gina Barkowsky +7 more
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Antibacterial Peptide Nucleic Acids—Facts and Perspectives [PDF]
Molecules, 2020 Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Monika Wojciechowska +4 more
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Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids [PDF]
Molecular Therapy: Nucleic Acids, 2021 Peptide nucleic acids (PNAs), a synthetic DNA mimic, have been extensively utilized for antisense- and antigene-based biomedical applications. Significant efforts have been made to increase the cellular uptake of PNAs, but here we examined relatively ...
Shipra Malik +2 more
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Peptide Nucleic Acids: Applications in Biomedical Sciences [PDF]
Molecules, 2020 The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
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Therapeutic and diagnostic applications of antisense peptide nucleic acids [PDF]
Molecular Therapy: Nucleic AcidsPeptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
Victoria MacLelland +2 more
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Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsSalmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh +4 more
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Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids
MethodsX, 2020 Peptide nucleic acids (PNAs) have emerged as one of the most versatile tools with a wide range of biomedical applications including antisense, antimiR, antigene, as well as site-specific gene editing.
Shipra Malik, Frank J Slack, Raman Bahal
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