Multifunctional Delivery Systems for Peptide Nucleic Acids [PDF]
The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a polyamide backbone—is continuously increasing in both in vitro and cellular systems and, parallel to this, delivery systems able to bring PNAs to their targets have
Stefano Volpi+3 more
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Exploiting Protected Maleimides to Modify Oligonucleotides, Peptides and Peptide Nucleic Acids [PDF]
This manuscript reviews the possibilities offered by 2,5-dimethylfuran-protected maleimides. Suitably derivatized building blocks incorporating the exo Diels-Alder cycloadduct can be introduced at any position of oligonucleotides, peptide nucleic acids ...
Clément Paris+3 more
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Antibacterial Peptide Nucleic Acids—Facts and Perspectives [PDF]
Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century.
Monika Wojciechowska+4 more
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Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Nucleic acid-based materials are usually only compatible with aqueous solutions. Here, the authors show a structural nucleic acid nanotechnology using gamma-modified peptide nucleic acids that enables formation of solvent-compatible, self-assembling ...
Sriram Kumar+3 more
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Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) [PDF]
Herein, we developed an innovative and easily accessible solid-phase synthetic protocol for Peptide Nucleic Acid (PNA) oligomers by systematically investigating the ultrasonication effects in all steps of the PNA synthesis (US-PNAS).
Alessandra Del Bene+9 more
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Potential of Peptide Nucleic Acids in Future Therapeutic Applications [PDF]
Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker.
Soheila Montazersaheb+2 more
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Subtractive modification of bacterial consortium using antisense peptide nucleic acids [PDF]
Microbiome engineering is an emerging research field that aims to design an artificial microbiome and modulate its function. In particular, subtractive modification of the microbiome allows us to create an artificial microbiome without the microorganism ...
Tatsuya Hizume+6 more
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Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA. [PDF]
We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm) of PNA+DNA duplexes by ...
Zheng H+7 more
europepmc +2 more sources
Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae [PDF]
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Gina Barkowsky+7 more
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Peptide Nucleic Acids: Applications in Biomedical Sciences [PDF]
The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
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