Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids. [PDF]
Mol Ther Nucleic Acids, 2021 Peptide nucleic acids (PNAs), a synthetic DNA mimic, have been extensively utilized for antisense- and antigene-based biomedical applications. Significant efforts have been made to increase the cellular uptake of PNAs, but here we examined relatively ...
Malik S, Saltzman WM, Bahal R.
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Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing
Molecules, 2018 Peptide nucleic acids (PNAs) can bind duplex DNA in a sequence-targeted manner, forming a triplex structure capable of inducing DNA repair and producing specific genome modifications.
Adele S. Ricciardi +4 more
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Therapeutic and diagnostic applications of antisense peptide nucleic acids. [PDF]
Mol Ther Nucleic AcidsPeptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
MacLelland V, Kravitz M, Gupta A.
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Peptide Nucleic Acid Microarrays [PDF]
, 2004 A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette Jacob +3 more
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Cyanobacteria produce N-(2-aminoethyl)glycine, a backbone for peptide nucleic acids which may have been the first genetic molecules for life on Earth. [PDF]
PLoS ONE, 2012 Prior to the evolution of DNA-based organisms on earth over 3.5 billion years ago it is hypothesized that RNA was the primary genetic molecule. Before RNA-based organisms arose, peptide nucleic acids may have been used to transmit genetic information by ...
Sandra Anne Banack +5 more
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Recent Advances in Chemical Modification of Peptide Nucleic Acids
Journal of Nucleic Acids, 2012 Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further ...
Eriks Rozners
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Peptide Nucleic Acids Promise New Therapeutics and Gene Editing Tools. [PDF]
ACS Cent Sci, 2023 Brazil R.
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A minimal hybridization chain reaction (HCR) system using peptide nucleic acids
Chemical Science, 2021 The HCR represents a powerful tool for amplification in DNA-based circuitry and sensing applications, yet requires the use of long DNA sequences to grant hairpin metastability.
Ki Tae Kim +2 more
semanticscholar +1 more source
Conformational constraints of cyclopentane peptide nucleic acids facilitate tunable binding to DNA.
Nucleic Acids Research, 2021 We report a series of synthetic, nucleic acid mimics with highly customizable thermodynamic binding to DNA. Incorporation of helix-promoting cyclopentanes into peptide nucleic acids (PNAs) increases the melting temperatures (Tm) of PNA+DNA duplexes by ...
Hongchao Zheng +7 more
semanticscholar +1 more source
Artificial genetic polymers against human pathologies
Biology Direct, 2022 Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community.
Gleb S. Ivanov +6 more
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