Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair
Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.
Nicholas G. Economos+5 more
doaj +2 more sources
Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing
Peptide nucleic acids (PNAs) can bind duplex DNA in a sequence-targeted manner, forming a triplex structure capable of inducing DNA repair and producing specific genome modifications.
Adele S. Ricciardi+4 more
doaj +2 more sources
Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids [PDF]
Peptide nucleic acids (PNAs), a synthetic DNA mimic, have been extensively utilized for antisense- and antigene-based biomedical applications. Significant efforts have been made to increase the cellular uptake of PNAs, but here we examined relatively ...
Shipra Malik+2 more
doaj +2 more sources
Detection of target DNA using fluorescent cationic polymer and peptide nucleic acid probes on solid support [PDF]
Background Nucleic acids detection using microarrays requires labelling of target nucleic acids with fluorophores or other reporter molecules prior to hybridization.
Leclerc Mario+7 more
doaj +2 more sources
Therapeutic and diagnostic applications of antisense peptide nucleic acids [PDF]
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
Victoria MacLelland+2 more
doaj +2 more sources
Cyanobacteria produce N-(2-aminoethyl)glycine, a backbone for peptide nucleic acids which may have been the first genetic molecules for life on Earth. [PDF]
Prior to the evolution of DNA-based organisms on earth over 3.5 billion years ago it is hypothesized that RNA was the primary genetic molecule. Before RNA-based organisms arose, peptide nucleic acids may have been used to transmit genetic information by ...
Sandra Anne Banack+5 more
doaj +2 more sources
Recent Advances in Chemical Modification of Peptide Nucleic Acids
Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further ...
Eriks Rozners
doaj +2 more sources
Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids [PDF]
Peptide nucleic acids (PNAs) have emerged as one of the most versatile tools with a wide range of biomedical applications including antisense, antimiR, antigene, as well as site-specific gene editing.
Shipra Malik, Frank J Slack, Raman Bahal
doaj +2 more sources
Peptide Nucleic Acids Promise New Therapeutics and Gene Editing Tools [PDF]
Rachel Brazil
doaj +2 more sources
Peptide Nucleic Acid Microarrays [PDF]
A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette Jacob+3 more
openalex +4 more sources