Results 11 to 20 of about 725,272 (355)

Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae [PDF]

Microbiology Spectrum, 2022
Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and is responsible for multiple other infectious diseases, such as meningitis and otitis media, in children.
Gina Barkowsky, Corina Abt, Irina Pöhner, Adam Bieda, Sven Hammerschmidt, Anette Jacob, Bernd Kreikemeyer, Nadja Patenge   +7 more
doaj   +2 more sources

Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids [PDF]

Molecular Therapy: Nucleic Acids, 2021
Peptide nucleic acids (PNAs), a synthetic DNA mimic, have been extensively utilized for antisense- and antigene-based biomedical applications. Significant efforts have been made to increase the cellular uptake of PNAs, but here we examined relatively ...
Shipra Malik, W. Mark Saltzman, Raman Bahal   +2 more
doaj   +2 more sources

Peptide Nucleic Acids: Applications in Biomedical Sciences [PDF]

Molecules, 2020
The DNA mimic, PNA (peptide nucleic acid), has been with us now for almost 3 decades [...]
Eylon Yavin
doaj   +2 more sources

Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

Molecules, 2020
Unusual nucleic acid structures are salient triggers of endogenous repair and can occur in sequence-specific contexts. Peptide nucleic acids (PNAs) rely on these principles to achieve non-enzymatic gene editing.
Nicholas G. Economos, Stanley Oyaghire, Elias Quijano, Adele S. Ricciardi, W. Mark Saltzman, Peter M. Glazer   +5 more
doaj   +2 more sources

Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing

Molecules, 2018
Peptide nucleic acids (PNAs) can bind duplex DNA in a sequence-targeted manner, forming a triplex structure capable of inducing DNA repair and producing specific genome modifications.
Adele S. Ricciardi, Elias Quijano, Rachael Putman, W. Mark Saltzman, Peter M. Glazer   +4 more
doaj   +2 more sources

Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]

Molecular Therapy: Nucleic Acids
Salmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh, Charles Viau, Nada Ahmed, Jianguo Xia, Xin Zhao   +4 more
doaj   +2 more sources

Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids

MethodsX, 2020
Peptide nucleic acids (PNAs) have emerged as one of the most versatile tools with a wide range of biomedical applications including antisense, antimiR, antigene, as well as site-specific gene editing.
Shipra Malik, Frank J Slack, Raman Bahal
doaj   +2 more sources

Recent Advances in Chemical Modification of Peptide Nucleic Acids

Journal of Nucleic Acids, 2012
Peptide nucleic acid (PNA) has become an extremely powerful tool in chemistry and biology. Although PNA recognizes single-stranded nucleic acids with exceptionally high affinity and sequence selectivity, there is considerable ongoing effort to further ...
Eriks Rozners
doaj   +2 more sources

Broad Host Range Peptide Nucleic Acids Prevent Gram-Negative Biofilms Implicated in Catheter-Associated Urinary Tract Infections [PDF]

Microorganisms
Biofilms develop in sequential steps resulting in the formation of three-dimensional communities of microorganisms that are encased in self-produced extracellular polymeric substances.
Hannah Q. Karp, Elizabeth S. Nowak, Gillian A. Kropp, Nihan A. Col, Michael D. Schulz, Nammalwar Sriranganathan, Jayasimha Rao   +6 more
doaj   +2 more sources

Stimuli-responsive assembly of bilingual peptide nucleic acids. [PDF]

RSC Chem Biol, 2022
Argueta-Gonzalez HS, Swenson CS, Song G, Heemstra JM.   +3 more
europepmc   +3 more sources