Results 11 to 20 of about 298,242 (342)

Synthesis and Purification of Peptide Nucleic Acids [PDF]

Current Protocols in Nucleic Acid Chemistry, 2002
Peptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2‐aminoethyl glycine linkages. Hybridization of PNAs with RNA or DNA follows normal rules for Watson‐Crick base pairing and occurs with high affinity.
Braasch, Dwaine A., Corey, David R., Nulf, Christopher J.   +2 more
core   +5 more sources

Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids [PDF]

Molecular Therapy: Nucleic Acids, 2021
Peptide nucleic acids (PNAs), a synthetic DNA mimic, have been extensively utilized for antisense- and antigene-based biomedical applications. Significant efforts have been made to increase the cellular uptake of PNAs, but here we examined relatively ...
Shipra Malik, W. Mark Saltzman, Raman Bahal   +2 more
doaj   +2 more sources

Peptide Nucleic Acid Microarrays [PDF]

, 2004
A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ...
Anette Jacob, Ole Brandt, Achim Stephan, Jörg D. Hoheisel   +3 more
openalex   +4 more sources

Therapeutic and diagnostic applications of antisense peptide nucleic acids [PDF]

Molecular Therapy: Nucleic Acids
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over
Victoria MacLelland, Madeline Kravitz, Anisha Gupta   +2 more
doaj   +2 more sources

Peptide Nucleic Acids [PDF]

, 1998
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Berg, Rolf Henrik, Buchardt, Ole, Engholm, Michael, Nielsen, Peter E.   +3 more
core   +4 more sources

Formulation of PLGA nanoparticles containing short cationic peptide nucleic acids [PDF]

MethodsX, 2020
Peptide nucleic acids (PNAs) have emerged as one of the most versatile tools with a wide range of biomedical applications including antisense, antimiR, antigene, as well as site-specific gene editing.
Shipra Malik, Frank J Slack, Raman Bahal
doaj   +2 more sources

Peptide Nucleic Acids Promise New Therapeutics and Gene Editing Tools [PDF]

ACS Central Science, 2023
Rachel Brazil
doaj   +2 more sources

Molecular Assembly of Triplex of Duplexes from Homothyminyl-Homocytosinyl Cγ(S/R)‑Bimodal Peptide Nucleic Acids with dA8/dG6 and the Cell Permeability of Bimodal Peptide Nucleic Acids [PDF]

ACS Omega, 2021
Pramod Bhingardeve, Prashant Jain, Krishna N. Ganesh   +2 more
doaj   +2 more sources

Artificial genetic polymers against human pathologies

Biology Direct, 2022
Originally discovered by Nielsen in 1991, peptide nucleic acids and other artificial genetic polymers have gained a lot of interest from the scientific community.
Gleb S. Ivanov, Vyacheslav G. Tribulovich, Nikolay B. Pestov, Temitope I. David, Abdul-Saleem Amoah, Tatyana V. Korneenko, Nikolai A. Barlev   +6 more
doaj   +1 more source

Sequence-Specific Recognition of Double-Stranded DNA by Peptide Nucleic Acid Forming Double-Duplex Invasion Complex

Applied Sciences, 2022
Peptide nucleic acid (PNA) is an analog of natural nucleic acids, where the sugar-phosphate backbone of DNA is replaced by an electrostatically neutral N-(2-aminoethyl)glycine backbone.
Yuichiro Aiba, Masanari Shibata, Osami Shoji   +2 more
doaj   +1 more source