Results 71 to 80 of about 677,914 (356)

Epitope mapping using mRNA display and a unidirectional nested deletion library [PDF]

, 2005
In vitro selection targeting an anti-polyhistidine monoclonal antibody was performed using mRNA display with a random, unconstrained 27-mer peptide library.
Ja, William W., Olsen, Brett N., Roberts, Richard W.   +2 more
core   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) [PDF]

, 2013
We demonstrate the first application of synthetic RNA gene silencers in Streptomyces coelicolor A3(2). Peptide nucleic acid and expressed antisense RNA silencers successfully inhibited actinorhodin production.
A Hesketh, Andrew Hesketh, CG Hebert, D D'alia, E Wagner, F Flett, Gabriel C. Uguru, GC Uguru, H Aiba, IL Hofacker, J Livny, J Livny, J Pánek, James E. M. Stach, JP Swiercz, L Good, L Good, Liam Good, LS Waters, M McArthur, M McArthur, Madhav Mondhe, Mark Isalan, Mervyn J. Bibb, MP Vockenhuber, MP Vockenhuber, MW Pfaffl, N Nakashima, N Nekhotiaeva, N Shen, NM Romero, NM Romero, P Hindra, R Dryselius, RP Desai, S Goh, S Herai, SG Kang, Shan Goh, T Morita, T Tezuka, TA Hjalt, W Minas, Y Chen   +43 more
core   +3 more sources

Peptide-nucleic acid nanostructures for transfection [PDF]

BioMolecular Concepts, 2012
AbstractTo use nucleic acids in biomedical research and medical applications, these highly hydrophilic macromolecules have to be transported through the organism, targeted to specific cell surfaces, and have to cross cellular barriers. To this end, nanosized transfection complexes have been designed and several of them have been successfully tested ...
openaire   +3 more sources

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

The Emerging 4D Printing of Shape‐Memory Thermomorphs for Self‐Adaptative Biomedical Implants

Advanced Functional Materials, EarlyView.
4D printing enables the creation of smart implants that adapt to changing conditions in the human body over time. At the core of this technology are shape‐memory thermomorphs (SMTMs). This review offers an in‐depth analysis of 4D printing with SMTMs, emphasizing the latest advancements in smart materials, stimuli, programming principles, and their ...
Aixiang Ding, Fang Tang, Eben Alsberg
wiley   +1 more source

Peptide-based vectors: recent developments

Biomolecular Concepts, 2014
Peptides and peptide-cargo complexes have been used for drug delivery and gene therapy. One of the most used delivery vectors are cell-penetrating peptides, due to their ability to be taken up by a variety of cell types and deliver a large variety of ...
Cerrato Carmine Pasquale, Lehto Tõnis, Langel Ülo   +2 more
doaj   +1 more source

PROTEOFORMER: deep proteome coverage through ribosome profiling and MS integration [PDF]

, 2014
An increasing amount of studies integrate mRNA sequencing data into MS-based proteomics to complement the translation product search space. However, several factors, including extensive regulation of mRNA translation and the need for three- or six-frame ...
Crappé, Jeroen, De Keulenaer, Sarah, De Meester, Ellen, De Meyer, Tim, Fijalkowska, Daria, Koch, Alexander, Menschaert, Gerben, Ndah, Elvis, Steyaert, Sandra, Van Criekinge, Wim, Van Damme, Petra   +10 more
core   +1 more source

Incorporation of thio-pseudoisocytosine into triplex-forming peptide nucleic acids for enhanced recognition of RNA duplexes

Nucleic Acids Research, 2014
Peptide nucleic acids (PNAs) have been developed for applications in biotechnology and therapeutics. There is great potential in the development of chemically modified PNAs or other triplex-forming ligands that selectively bind to RNA duplexes, but not ...
Gitali Devi, Zhen Yuan, Yunpeng Lu, Yanli Zhao, Gang Chen   +4 more
semanticscholar   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source