Peptide barcoding for one-pot evaluation of sequence–function relationships of nanobodies
Scientific Reports, 2021 Optimisation of protein binders relies on laborious screening processes. Investigation of sequence–function relationships of protein binders is particularly slow, since mutants are purified and evaluated individually. Here we developed peptide barcoding,
Yusei Matsuzaki +10 more
doaj +1 more source
The Cell Adhesion Activity of the Joining Peptide of Proopiomelanocortin
Molecules, 2023 Proopiomelanocortin (POMC) is a precursor protein of several peptide hormones, such as ACTH and β-endorphin. Almost all of the peptide hormones in POMC have been drastically investigated in terms of their biological activities.
Kyona Hiroshima +4 more
doaj +1 more source
Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]
, 2018 Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S. +12 more
core +1 more source
Peptide detection of fungal functional amyloids in infected tissue. [PDF]
PLoS ONE, 2014 Many fungal cell adhesion proteins form functional amyloid patches on the surface of adhering cells. The Candida albicans Agglutinin-like sequence (Als) adhesins are exemplars for this phenomenon, and have amyloid forming sequences that are conserved ...
Melissa C Garcia-Sherman +6 more
doaj +1 more source
Journal of the American Chemical Society, 2019 Just as peptide function is determined by the position, sequence, and overall arrangement of constituent amino acids, the optical proper-ties of nanoparticle (NP) assemblies are influenced by the size, dimensions, and arrangement of constituent NPs.
Soumitra Mokashi-Punekar +2 more
semanticscholar +1 more source
BRUCE: a program for the detection of transfer-messenger RNA genes in nucleotide sequences [PDF]
, 2002 A computer program, BRUCE, was developed for the identification of transfer‐messenger RNA (tmRNA) genes. The program employs heuristic algorithms to search for a tRNAAla‐like secondary structure surrounding a short sequence encoding the tag peptide.
Andersson, S., Canback, B., Laslett, D.
core +3 more sources
Life, 2022 The peptidyl transferase center (PTC) in the ribosome is composed of two symmetrically arranged tRNA-like units that contribute to peptide bond formation.
Mai Kawabata +5 more
doaj +1 more source
Cloning Trap for Signal Peptide Sequences [PDF]
BioTechniques, 2000 Novel secreted and/or type I transmembrane proteins containing N-terminal signal sequences have been successfully cloned using the signal sequence trapping (SST) method. Often this involves random cloning of short 5' cDNA terminal ends into an epitope-tagged expression vector and the detection of expressed recombinant proteins on the cell surfaces of ...
Lim SP, GARZINO DEMO, ALFREDO
openaire +5 more sources
Immunological reactivity of a human immunodeficiency virus type I derived peptide representing a consensus sequence of the GP120 major neutralizing region V3 [PDF]
, 1992 To reduce the opportunities for human immunodeficiency virus type 1 (HIV-1) to evade vaccine induced immunity, the development of subunit vaccines must focus on the characterization of immunogenic epitopes, which are major targets for the immune system ...
Böltz, T. +6 more
core +1 more source
A Novel Peptide from Soybean Protein Isolate Significantly Enhances Resistance of the Organism under Oxidative Stress. [PDF]
PLoS ONE, 2016 Recent studies have indicated that protein hydrolysates have broad biological effects. In the current study we describe a novel antioxidative peptide, FDPAL, from soybean protein isolate (SPI).
Heran Ma +7 more
doaj +1 more source