Results 291 to 300 of about 1,122,450 (358)

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry. [PDF]

Nat Commun
Nakashima KK, Mihoubi FZ, Saraya JS, Russell KO, Rahmatova F, Robinson JD, Maristany MJ, Huertas J, Rubio-Sánchez R, Collepardo-Guevara R, O'Flaherty DK, Bonfio C.   +11 more
europepmc   +1 more source

Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior

Advanced Healthcare Materials, EarlyView.
Fibrous structures are key elements of the native extracellular matrix and crucial for directing cell behavior. This review discusses how fiber properties such as composition, diameter, and alignment affect cell responses in 2D and 3D systems. Strategies for integrating fibrous cues into engineered tissues are highlighted, and future directions for ...
Zan Lamberger, Gregor Lang
wiley   +1 more source

DigDig: A Software for In-Depth Analysis and Comparison of Proteolytic Digestion. [PDF]

Anal Chem
Kalaninová Z, Portašiková JM, Kavan D, Novák P, Man P.   +4 more
europepmc   +1 more source

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Advanced Healthcare Materials, EarlyView.
Design rules are presented to control intestinal organoid polarity in fully synthetic hydrogels. The laminin‐derived IKVAV sequence is crucial to obtain correct intestinal organoid polarity. Increasing hydrogel dynamics further supports the growth of correctly polarized intestinal organoids, while a bulk level of stiffness (G’ ≈ 0.7 kPa) is crucial to ...
Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers   +10 more
wiley   +1 more source

DLFea4AMPGen de novo design of antimicrobial peptides by integrating features learned from deep learning models. [PDF]

Nat Commun
Gao H, Guan F, Luo B, Zhang D, Liu W, Shen Y, Fan L, Xu G, Wang Y, Tu T, Wu N, Yao B, Luo H, Teng Y, Tian J, Huang H.   +15 more
europepmc   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Norbornene Homopolymerization Limits Cell Spreading in Thiol–Ene Photoclick Hydrogels

Advanced Healthcare Materials, EarlyView.
Thiol–norbornene click reactions are often used in the development of cell‐permissive 3D hydrogels. However, ene–ene crosslinks in other thiol–ene systems are known to limit permissivity. This study demonstrates the negative effects of norbornene homopolymerization on 3D cell spreading and circumvents the issue by modulating polymer degree of ...
James L. Gentry, Steven R. Caliari
wiley   +1 more source

Dipole-Induced Inversion of Spin-Dependent Charge Transport through α-Helical Peptide-Based Single-Molecule Junctions. [PDF]

J Am Chem Soc
Aragonès AC, Varese M, Garg K, Kuang W, Wang Q, Giralt E, Mujica V, Gutierrez R, Cuniberti G, Puerta L, Díez-Pérez I.   +10 more
europepmc   +1 more source

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D‐Peptide‐Ruthenium Prodrug Conjugate

Advanced Healthcare Materials, EarlyView.
Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N. van Ginkel, Wen Sun, Sylvestre Bonnet   +7 more
wiley   +1 more source

Physics-based evolution of transmembrane helices reveals mechanisms of cholesterol attraction. [PDF]

Nat Commun
Methorst J, Verwei N, Hoffmann C, Chodnicki P, Sansevrino R, Pyne P, Wang H, van Hilten N, Aschmann D, Kros A, Andreas L, Czub J, Milovanovic D, Risselada HJ.   +13 more
europepmc   +1 more source