Results 301 to 310 of about 1,122,450 (358)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Multi-region mapping of ligand binding and structural changes in the β-1 adrenergic receptor using carbene footprinting and mass spectrometry. [PDF]

Chem Sci
Lloyd JR, Varughese AS, Kapoor P, Dürr KL, Yen HY, Jazayeri A, Hopper JTS, Oldham NJ.   +7 more
europepmc   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

LassoESM a tailored language model for enhanced lasso peptide property prediction. [PDF]

Nat Commun
Mi X, Barrett SE, Mitchell DA, Shukla D.
europepmc   +1 more source

HEPAD: enhancing hemolytic peptide prediction with adaptive feature engineering and diverse sequence descriptors. [PDF]

BMC Bioinformatics
Chen SH, Yu JC, Lin YH, Kuo SC, Ni K, Chen CT.   +5 more
europepmc   +1 more source

An innovative peptide toxicity prediction model based on multi-scale convolutional neural network and residual connection. [PDF]

Bioinformatics
Zhang S, Ren J, Liang Y.
europepmc   +1 more source

Truncated and Disubstituted (P4K and L7R) Oncocin Peptides Target the Ribosome with Improved Antibacterial Activity. [PDF]

ACS Omega
Wolak T, Islam R, Venneti NM, Stockdill JL, Nguyen HM, Chow CS.   +5 more
europepmc   +1 more source

The abc's (and xyz's) of peptide sequencing [PDF]

Nature Reviews Molecular Cell Biology, 2004
Proteomics is an increasingly powerful and indispensable technology in molecular cell biology. It can be used to identify the components of small protein complexes and large organelles, to determine post-translational modifications and in sophisticated functional screens.
Matthias Mann, Hanno Steen
openaire   +2 more sources

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Peptide sequencing program

Bioinformatics, 1986
A computer program has been devised to automate rationalization of peptide fragmentation patterns. The program systematically generates all possible linear amino acid sequences which might be attributable to a peptide with a known amino acid composition.
C. W. Hamm, W. E. Wilson, D. J. Harvan
openaire   +3 more sources