Results 101 to 110 of about 627,325 (311)

Natriuretic peptide receptors on rat thymocytes: Inhibition of proliferation by atrial natriuretic peptide. [PDF]

, 1996
Because the thymus expresses the natriuretic peptides (NP) as well as their respective receptors, an involvement of NP in the physiology of this organ has been suggested.
Schmidt, Karin-Nicole, Vollmar, Angelika M., Schulz, Rüdiger, A. M. Vollmar   +3 more
core   +1 more source

Thioimidate Solutions to Thioamide Problems during Peptide Synthesis

, 2023
Thioamides have structural and chemical similarity to peptide bonds, and therefore offer valuable insights when probing peptide backbone interactions, including hydrogen bonding, stereoelectronic, and hydrophobicity effects.
Rida, Ibrahim, Aaron, Donovan, Krishna, Sharma, Jacob, Byerly-Duke, Brett, VanVeller   +4 more
core   +1 more source

Partial thioamide scan on the lipopeptaibiotic trichogin GA IV. Effects on folding and bioactivity

Beilstein Journal of Organic Chemistry, 2012
Backbone modification is a common chemical tool to control the conformation of linear peptides and to explore potentially useful effects on their biochemical and biophysical properties.
Marta De Zotti, Barbara Biondi, Cristina Peggion, Matteo De Poli, Haleh Fathi, Simona Oancea, Claudio Toniolo, Fernando Formaggio   +7 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Solid-phase peptide synthesis at elevated temperatures: a search for an optimized synthesis condition of unsulfated cholecystokinin-12

, 1997
A systematic investigation of solid-phase peptide synthesis at elevated temperatures using the well-known aggregating peptide acyl carrier protein (65-74) and the unsulfated cholecystokinin-8 as models is presented. The main goal of the investigation was
Varanda, Leandro M., Miranda, M Teresa M
core   +1 more source

Nucleic Acid Carriers Based on Precise Polymer Conjugates [PDF]

, 2011
Polymer polydispersity, random conjugation of functional groups, and poorly understood structure–activity relationships have constantly hampered progress in the development of nucleic acid carriers.
Christina Troiber, Troiber, Christina, Wagner, Ernst, Ernst Wagner   +3 more
core   +1 more source

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis–Associated Interstitial Lung Disease Risk

Arthritis Care &Research, EarlyView.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase‐7 (MMP‐7), and serum anti–malondialdehyde‐acetaldehyde (anti‐MAA) antibody for rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) risk stratification.
Kelsey Coziahr, Austin M. Wheeler, Brent A. Luedders, Michael Duryee, Halie Frideres, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Dana P. Ascherman, Paul A. Monach, Gail S. Kerr, Andreas M. Reimold, Scott M. Matson, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +16 more
wiley   +1 more source

Chemical synthesis of proteins: a tool for protein labeling

, 2010
An ingenious stratagem useful to understand and modulate the structural and functional features of the proteins refers to the modification of their chemical structure.
De Rosa, Lucia
core  

Understanding Acid Lability of Cysteine Protecting Groups

Molecules, 2013
Cys-disulfide bonds contribute to the stabilization of peptide and protein structures. The synthesis of these molecules requires a proper protection of Cys residues, which is crucial to prevent side-reactions and also to achieve the correct Cys ...
Iván Ramos-Tomillero, Lorena Mendive-Tapia, Miriam Góngora-Benítez, Ernesto Nicolás, Judit Tulla-Puche, Fernando Albericio   +5 more
doaj   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source