Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function
Advanced Functional Materials, EarlyView.Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh +3 more
wiley +1 more source
ON THE ASYMMETRIC COURSE OF THE ENZYMATIC SYNTHESIS OF PEPTIDE BONDS
, 1938 Max Bergmann, Otto K. Behrens
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Catalysis in Peptide Synthesis with Active Esters. II. Effects of Concentrated Carboxylic Acids on the Aminolysis of Benzyloxycarbonyl-L-phenylalaninep-Nitrophenyl Ester in Dioxane [PDF]
, 1969 Nobuhiro Nakamizo
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Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells
Advanced Functional Materials, EarlyView.Two populations of protocells consisting of giant unilamellar vesicles containing active species and distinct artificial organelles are competent of collective behavior by mimicking production, intercellular communication, and detection of the bioinspired signal molecule lactate. Enzymatic cascade reactions within artificial organelles demonstrate that
Arianna Balestri +4 more
wiley +1 more source
A Sustainable Biotechnology Approach for Mineral Separation
Advanced Functional Materials, EarlyView.Silver‑binding peptides are first identified through phage‐display screening, and then engineered into multifunctional and responsive peptides or proteins. These tailored biomolecules can selectively capture and aggregate silver particles or ions from complex mixtures, enabling rapid and efficient silver separation and recovery.
Guangze Yang +7 more
wiley +1 more source
A New Method for the Protection of the Sulfhydryl Group during Peptide Synthesis [PDF]
, 1964 Shiro Akabori +3 more
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Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury
Advanced Functional Materials, EarlyView.After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen +9 more
wiley +1 more source
Acid-Modulated Peptide Synthesis for Application on Oxide Biosensor Interfaces. [PDF]
Nanomaterials (Basel), 2023 Cristóbal-Lecina E +7 more
europepmc +1 more source
Metal Nanoclusters for Cancer Imaging and Treatment
Advanced Functional Materials, EarlyView.This review aims to provide a comprehensive summary and discussion of the core–shell design capabilities of metal nanoclusters (NCs) at the atomic level for cancer imaging and treatment. It offers essential insights into the design principles of metal NCs while also encouraging the exploration of other nanomaterials and their potential theranostic ...
Haiguang Zhu +5 more
wiley +1 more source
Enzymatic Synthesis of the Peptide in Bacterial Uridine Nucleotides
, 1962 Eiji Ito, Jack L. Strominger
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