Results 201 to 210 of about 594,502 (265)

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Identification of virus epitopes and reactive T-cell receptors from memory T cells without peptide synthesis. [PDF]

Commun Biol
Wang L, Xu R, Huang D, Peng P, Sun K, Hu J, Liu BZ, Fang L, Zhang L, Sun X, Gu F, Tang N, Huang AL, Lin X, Lan X.   +14 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Towards green, scalable peptide synthesis: leveraging DEG-crosslinked polystyrene resins to overcome hydrophobicity challenges. [PDF]

RSC Adv
Al Musaimi O, Tomkins J, Barry SM, Basso A, Kou X, Zhang C, Serban S.   +6 more
europepmc   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets. [PDF]

ACS Cent Sci
Charalampidou A, Nehls T, Meyners C, Gandhesiri S, Pomplun S, Pentelute BL, Lermyte F, Hausch F.   +7 more
europepmc   +1 more source

Synthesis of atom-precise supported metal clusters <i>via</i> solid-phase peptide synthesis. [PDF]

Chem Sci
Imaoka T, Antoku N, Narita Y, Nishiyama K, Takada K, Saito S, Tanaka M, Okochi M, Huda M, Tanabe M, Chun WJ, Yamamoto K.   +11 more
europepmc   +1 more source

Membrane bound geranylated RNAs establish a primitive peptide synthesis system

Chan C, Singer J, Carell T.
europepmc   +1 more source

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Synthesis of Peptide Aldehydes

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Moulin, Aline, Fehrentz, Jean-Alain, Martinez, Jean   +2 more
openaire   +3 more sources

Automated Peptide Synthesis

Nature, 1965
The value of synthetic organic chemistry to our understanding of the action of hypotensive peptides, and other biologically active peptides, has been well demonstrated. For example, the structure of bradykinin was originally established not only by degradative procedures (Elliott et al., 1960) but also by synthesis (Boissonnas et al., 1960).
R B, Merrifield, J M, Stewart
openaire   +2 more sources