Results 241 to 250 of about 855,791 (338)

Dendrimer Conjugates with PD‐L1‐Binding Peptides Enhance In Vivo Antitumor Immune Response

Advanced Healthcare Materials, EarlyView.
In this paper, a novel nanoparticle scaffold composed of dendrimers conjugated with peptide‐based immune checkpoint inhibitors, enhancing drug delivery efficacy is introduced. By conjugating PD‐L1‐binding peptides to dendrimers, multivalent binding effects are harnessed, resulting in enhanced binding affinity, prolonged half‐life, and improved ...
DaWon Kim, Jin Woong Lee, Piper A. Rawding, Mari Iida, Carter Kim, Kourtney L. Kostecki, Michael J. Poellmann, Bridget Crossman, Ashley S. Liu, YoungSoo Kim, Deric L. Wheeler, Seungpyo Hong   +11 more
wiley   +1 more source

A potential role for RNA aminoacylation prior to its role in peptide synthesis. [PDF]

Proc Natl Acad Sci U S A
Radakovic A, Lewicka A, Todisco M, Aitken HRM, Weiss Z, Kim S, Bannan A, Piccirilli JA, Szostak JW.   +8 more
europepmc   +1 more source

Studies on Peptides. XXIV. Some Observation on the Urethan Formation during the Mixed Anhydride Procedure in Peptide Synthesis

, 1969
Haruaki Yajima, Nariakira Mizokami, Yoshio Okada, Koichi Kawasaki   +3 more
openalex   +2 more sources

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Safety-Catch Linkers for Solid-Phase Peptide Synthesis. [PDF]

Molecules
Noki S, de la Torre BG, Albericio F.
europepmc   +1 more source

Studies on Peptides. IV. The Synthesis of D-Histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycine and L-Histidyl-L-phenylalanyl-L-arginyl-D-tryptophylglycine and Their Physiological Properties in Frog melanocyte in vitro

, 1965
Haruaki Yajima, Kazuo Kubo
openalex   +2 more sources

Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications

Advanced Healthcare Materials, EarlyView.
Porosity governs transport mechanics in hydrogels, yet characterization in its native state remains challenging. This work harnesses particle tracking to uncover three‐dimensional pore geometric features in polyethylene glycol hydrogels. Measurements in the native state reveal pores characteristics are comparable to those obtained by cryogenic scanning
M. A. Kristine Tolentino, Eric Y. Du, Giulia Silvani, Elvis Pandzic, Kristopher A. Kilian, J. Justin Gooding   +5 more
wiley   +1 more source

Nutritional Modulation of Host Defense Peptide Synthesis: A Novel Host-Directed Antimicrobial Therapeutic Strategy? [PDF]

Adv Nutr
Whitmore M, Tobin I, Burkardt A, Zhang G.   +3 more
europepmc   +1 more source

Studies on Peptides. VII. Synthesis of Three Stereoisomeric Pentapeptides of Histidylphenylalanylarginyltryptophylglycine and Their Melanocyte-Stimulating Activities in vitro

, 1966
Haruaki Yajima, Kazuo Kubo, Takao Oshima, Kotobuki Hano, Masao Koida   +4 more
openalex   +2 more sources

Involvement of the relA gene product and feedback inhibition in the regulation of DUP-N-acetylmuramyl-peptide synthesis in Escherichia coli. [PDF]

, 1978
E E Ishiguro, William D. Ramey
openalex   +1 more source