Results 1 to 10 of about 2,785,119 (387)

VGF changes during the estrous cycle: a novel endocrine role for TLQP peptides? [PDF]

open access: yes, 2014
Although the VGF derived peptide TLQP-21 stimulates gonadotropin-releasing hormone (GnRH) and gonadotropin secretion, available data on VGF peptides and reproduction are limited.
Brancia C   +4 more
core   +15 more sources

SignalP 6.0 predicts all five types of signal peptides using protein language models

open access: yesNature Biotechnology, 2022
Signal peptides (SPs) are short amino acid sequences that control protein secretion and translocation in all living organisms. SPs can be predicted from sequence data, but existing algorithms are unable to detect all known types of SPs.
Felix Teufel   +9 more
semanticscholar   +1 more source

The correlation between maternal age, parity, cardiac diastolic function and occurrence rate of pre-eclampsia

open access: yesScientific Reports, 2021
To evaluate the effect of age and parity on maternal cardiac diastolic function in second trimester among pregnant women with normal left ventricular ejection fraction. To analyze the correlation between impaired diastolic function and pre-eclampsia.
Dan Zhu   +5 more
doaj   +1 more source

Therapeutic peptides: current applications and future directions

open access: yesSignal Transduction and Targeted Therapy, 2022
Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and ...
Lei Wang   +8 more
semanticscholar   +1 more source

Hairless canary seeds (Phalaris canariensis L.) as a potential source of antioxidant, antihypertensive, antidiabetic, and antiobesity biopeptides

open access: yesFood Production, Processing and Nutrition, 2021
Rising consumer concerns with synthetic drugs to treat non-communicable diseases (NCDs) have promoted a shift towards using natural biological active constituents that offer similar health benefits.
U. C. Urbizo-Reyes   +2 more
doaj   +1 more source

Secondary Metabolites with Cytotoxic Activities from Streptomyces sp. BM-8 Isolated from the Feces of Equusquagga

open access: yesMolecules, 2021
A new aliphatic acid, compound 1, together with six known metabolites, including nonactic acid (2), homononactic acid (3), ethyl homononactate (4), homononactylhomononactate (5), valinomycin (6), and cyclo-(Pro-Leu) (7), was isolated from the culture ...
Shengsheng Lu   +6 more
doaj   +1 more source

Vertebrate OTOP1 is also an alkali-activated channel

open access: yesNature Communications, 2023
pH sensation is critical for survival of vertebrates. Here, authors found six vertebrate OTOP1 channels that were highly conserved and directly activated by extracellular alkali.
Lifeng Tian   +7 more
doaj   +1 more source

Cyclic Peptides for Drug Development.

open access: yesAngewandte Chemie, 2023
Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives.
Xinjian Ji   +2 more
semanticscholar   +1 more source

Caveolin-Mediated Internalization of Fmoc-FF Nanogels in Breast Cancer Cell Lines

open access: yesPharmaceutics, 2023
Introduction: Hydrogel nanoparticles, also known as nanogels (NGs), have been recently proposed as alternative supramolecular vehicles for the delivery of biologically relevant molecules like anticancer drugs and contrast agents. The inner compartment of
Giovanni Smaldone   +6 more
doaj   +1 more source

Bioactive Peptides: Synthesis, Sources, Applications, and Proposed Mechanisms of Action

open access: yesInternational Journal of Molecular Sciences, 2022
Bioactive peptides are a group of biological molecules that are normally buried in the structure of parent proteins and become active after the cleavage of the proteins.
Mohsen Akbarian   +3 more
semanticscholar   +1 more source

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