Results 81 to 90 of about 2,534,576 (425)
Journal of Peptide Science, 2019 The protein universe as we know is composed of folded structures and intrinsic disordered regions. The latter may adopt structures upon interaction with binding partners. In addition, some proteins contain C‐terminal extensions which act as independent functional units in the context of the protein.
Benedikt Weber +2 more
openaire +4 more sources
Journal of Fungi, 2021 Fungal infections represent an increasing public health crisis [...]
openaire +3 more sources
Electron Capture Dissociation Mass Spectrometry of Tyrosine Nitrated Peptides [PDF]
, 2010 In vivo protein nitration is associated with many disease conditions that involve oxidative stress and inflammatory response. The modification involves addition of a nitro group at the position ortho to the phenol group of tyrosine to give 3 ...
A. J. Creese +47 more
core +2 more sources
Antimicrobial Peptides: Mechanisms of Action and Resistance
Journal of dentistry research, 2017 More than 40 antimicrobial peptides and proteins (AMPs) are expressed in the oral cavity. These AMPs have been organized into 6 functional groups, 1 of which, cationic AMPs, has received extensive attention in recent years for their promise as potential ...
B. Bechinger, Sven Ulrik Gorr
semanticscholar +1 more source
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
Influence of pH and sequence in peptide aggregation via molecular simulation [PDF]
, 2015 We employ a recently developed coarse-grained model for peptides and proteins where the effect of pH is automatically included. We explore the effect of pH in the aggregation process of the amyloidogenic peptide KTVIIE and two related sequences, using three different pH environments. Simulations using large systems (24 peptides chains per box) allow us
arxiv +1 more source
Concerted Rolling and Membrane Penetration Revealed by Atomistic Simulations of Antimicrobial Peptides [PDF]
arXiv, 2021 Short peptides with antimicrobial activity have therapeutic potential for treating bacterial infections. Mechanisms of actions for antimicrobial peptides require binding the biological membrane of their target, which often represents a key mechanistic step.
arxiv
Exploring the Brainpeps database [PDF]
, 2012 Since the discovery that peptides can cross the blood-brain barrier (BBB), doors have been opened to new therapeutics for CNS diseases and pain management.
Bracke, Nathalie +4 more
core +1 more source
A Condensation-Ordering Mechanism in Nanoparticle-Catalyzed Peptide Aggregation [PDF]
, 2009 Nanoparticles introduced in living cells are capable of strongly promoting the aggregation of peptides and proteins. We use here molecular dynamics simulations to characterise in detail the process by which nanoparticle surfaces catalyse the self ...
A Aggeli +62 more
core +5 more sources
Whey-derived peptides interactions with ACE by molecular docking as a potential predictive tool of natural ACE inhibitors [PDF]
, 2020 Several milk/whey derived peptides possess high in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. However, in some cases, poor correlation between the in vitro ACE inhibitory activity and the in vivo antihypertensive activity has been ...
Chamata, Yara +2 more
core +1 more source