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Recent Advances in Peptidoglycan Synthesis and Regulation in Bacteria

open access: yesBiomolecules, 2023
Bacteria must synthesize their cell wall and membrane during their cell cycle, with peptidoglycan being the primary component of the cell wall in most bacteria.
Anne Galinier   +4 more
doaj   +2 more sources

Imbalance of peptidoglycan biosynthesis alters the cell surface charge of Listeria monocytogenes

open access: yesThe Cell Surface, 2022
The bacterial cell wall is composed of a thick layer of peptidoglycan and cell wall polymers, which are either embedded in the membrane or linked to the peptidoglycan backbone and referred to as lipoteichoic acid (LTA) and wall teichoic acid (WTA ...
Lisa Maria Schulz   +4 more
doaj   +1 more source

Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. [PDF]

open access: yesPLoS ONE, 2008
We hypothesized that the peptidoglycan component of B. anthracis may play a critical role in morbidity and mortality associated with inhalation anthrax. To explore this issue, we purified the peptidoglycan component of the bacterial cell wall and studied
Marybeth Langer   +8 more
doaj   +1 more source

Class A Penicillin-Binding Protein C Is Responsible for Stress Response by Regulation of Peptidoglycan Assembly in Clavibacter michiganensis

open access: yesMicrobiology Spectrum, 2022
The cell wall peptidoglycan of bacteria is essential for their survival and shape development. The penicillin-binding proteins (PBPs) are responsible for the terminal stage of peptidoglycan assembly.
Xing Chen   +8 more
doaj   +1 more source

Effect of D-Ala-Ended Peptidoglycan Precursors on the Immune Regulation of Lactobacillus plantarum Strains

open access: yesFrontiers in Immunology, 2022
The resistance of Lactobacillus plantarum to vancomycin depends on its peptidoglycan composition. Vancomycin has poor binding affinity with peptidoglycan precursors ending in D-alanyl-D-lactate (D-Ala-D-Lac) but binds strongly to peptidoglycan precursors
Xin Song   +5 more
doaj   +1 more source

Peptidoglycan enzymes of Francisella: Roles in cell morphology and pathogenesis, and potential as therapeutic targets

open access: yesFrontiers in Microbiology, 2023
Peptidoglycan, found within the cell wall of bacteria, is a structure critical for maintaining cell morphology and providing a protective barrier in diverse environments. Peptidoglycan is a remarkably dynamic structure that is constantly remodeled during
Beth A. Bachert, Joel A. Bozue
doaj   +1 more source

Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products

open access: yeseLife, 2022
The peptidoglycan cell wall is a predominant structure of bacteria, determining cell shape and supporting survival in diverse conditions. Peptidoglycan is dynamic and requires regulated synthesis of new material, remodeling, and turnover – or autolysis –
Anna Isabell Weaver   +7 more
doaj   +1 more source

An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis.

open access: yesPLoS Pathogens, 2023
The obligate intracellular Chlamydiaceae do not need to resist osmotic challenges and thus lost their cell wall in the course of evolution. Nevertheless, these pathogens maintain a rudimentary peptidoglycan machinery for cell division.
Jula Reuter   +16 more
doaj   +1 more source

The Role of Mre Factors and Cell Division in Peptidoglycan Growth in the Multicellular Cyanobacterium Anabaena

open access: yesmBio, 2022
Bacteria in general serve two main tasks: cell growth and division. Both processes include peptidoglycan extension to allow cell expansion and to form the poles of the daughter cells, respectively.
Cristina Velázquez-Suárez   +3 more
doaj   +1 more source

The Absence of a Mature Cell Wall Sacculus in Stable Listeria monocytogenes L-Form Cells Is Independent of Peptidoglycan Synthesis. [PDF]

open access: yesPLoS ONE, 2016
L-forms are cell wall-deficient variants of otherwise walled bacteria that maintain the ability to survive and proliferate in absence of the surrounding peptidoglycan sacculus.
Patrick Studer   +7 more
doaj   +1 more source

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