Results 31 to 40 of about 111,225 (303)
Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing [PDF]
, 2007 Airway infection by the Gram-positive pathogen Streptococcus pneumoniae (Sp) leads to recruitment of neutrophils but limited bacterial killing by these cells.
Adam J Ratner +20 more
core +1 more source
Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis [PDF]
, 2009 An important question in Systems Biology is the design of experiments that enable discrimination between two (or more) competing chemical pathway models or biological mechanisms.
Roper, D. +23 more
core +1 more source
, 2022 Grimes, Catherine LeimkuhlerThe bacterial cell wall fragment, muramyl dipeptide, has been recognized since the 1970s as the minimal fragment necessary to initiate an innate immune response.
Melnyk, James E.
core +1 more source
Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae. [PDF]
PLoS Pathogens, 2008 The abundance of lysozyme on mucosal surfaces suggests that successful colonizers must be able to evade its antimicrobial effects. Lysozyme has a muramidase activity that hydrolyzes bacterial peptidoglycan and a non-muramidase activity attributable to ...
Kimberly M Davis +3 more
doaj +1 more source
Microbiology Spectrum, 2023 Peptidoglycan is an essential component of the bacterial cell envelope that sustains the turgor pressure of the cytoplasm, determines cell shape, and acts as a scaffold for the anchoring of envelope polymers such as lipoproteins.
Inès Hugonneau-Beaufet +7 more
doaj +1 more source
Peptidoglycan Composition in Neisseria [PDF]
, 2019 The composition of Neisseria peptidoglycan has been of scientific interest for over four decades. Initial investigations focused on discovering the mechanisms causing rising rates of antibiotic resistance in N. gonorrhoeae by determining differences in peptidoglycan composition in penicillin susceptible and resistant strains.
Ryan E, Schaub, Joseph P, Dillard
openaire +2 more sources
Peptidoglycan: Structure, Synthesis, and Regulation
, 2021 Peptidoglycan is a defining feature of the bacterial cell wall. Initially identified as a target of the revolutionary beta-lactam antibiotics, peptidoglycan has become a subject of much interest for its biology, its potential for the discovery of novel ...
Slauch, James M. +3 more
core +1 more source
Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs) [PDF]
Proceedings of the National Academy of Sciences, 2006 The innate immune system constitutes the first line of defense against microorganisms in both vertebrates and invertebrates. Although much progress has been made toward identifying key receptors and understanding their role in host defense, far less is known about how these receptors recognize microbial ligands. Such studies have been severely hampered
Swaminathan, Chittoor P. +8 more
openaire +3 more sources
Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria
eLife, 2018 Rod-shaped mycobacteria expand from their poles, yet d-amino acid probes label cell wall peptidoglycan in this genus at both the poles and sidewall. We sought to clarify the metabolic fates of these probes.
Alam García-Heredia +10 more
doaj +1 more source
PLoS ONE, 2021 Daptomycin is a cyclic lipopeptide antibiotic used in the clinic for treatment of severe enterococcal infections. Recent reports indicate that daptomycin targets active cellular processes, specifically, peptidoglycan biosynthesis. Within, we examined the
Rachel D Johnston +4 more
doaj +1 more source