Results 21 to 30 of about 99,406 (260)
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionMycobacteria assemble a complex cell wall with cross-linked peptidoglycan (PG) which plays an essential role in maintenance of cell wall integrity and tolerance to osmotic pressure.
Moagi T. Shaku +6 more
doaj +1 more source
Microbiology Spectrum, 2015 ABSTRACT Bacterial endospores possess multiple integument layers, one of which is the cortex peptidoglycan wall. The cortex is essential for the maintenance of spore core dehydration and dormancy and contains structural modifications that differentiate it from vegetative cell peptidoglycan and determine its fate during spore ...
David L, Popham, Casey B, Bernhards
openaire +2 more sources
Structural basis for peptidoglycan binding by peptidoglycan recognition proteins [PDF]
Proceedings of the National Academy of Sciences, 2004 Peptidoglycan (PGN) recognition proteins (PGRPs) are pattern-recognition receptors of the innate immune system that bind and, in some cases, hydrolyze bacterial PGNs. We determined the crystal structure, at 2.30-Å resolution, of the C-terminal PGN-binding domain of human PGRP-Iα in complex with a muramyl tripeptide representing the
Rongjin, Guan +5 more
openaire +2 more sources
Resistance to mucosal lysozyme compensates for the fitness deficit of peptidoglycan modifications by Streptococcus pneumoniae. [PDF]
PLoS Pathogens, 2008 The abundance of lysozyme on mucosal surfaces suggests that successful colonizers must be able to evade its antimicrobial effects. Lysozyme has a muramidase activity that hydrolyzes bacterial peptidoglycan and a non-muramidase activity attributable to ...
Kimberly M Davis +3 more
doaj +1 more source
Microbiology Spectrum, 2023 Peptidoglycan is an essential component of the bacterial cell envelope that sustains the turgor pressure of the cytoplasm, determines cell shape, and acts as a scaffold for the anchoring of envelope polymers such as lipoproteins.
Inès Hugonneau-Beaufet +7 more
doaj +1 more source
Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria
eLife, 2018 Rod-shaped mycobacteria expand from their poles, yet d-amino acid probes label cell wall peptidoglycan in this genus at both the poles and sidewall. We sought to clarify the metabolic fates of these probes.
Alam García-Heredia +10 more
doaj +1 more source
Peptidoglycan Composition in Neisseria [PDF]
, 2019 The composition of Neisseria peptidoglycan has been of scientific interest for over four decades. Initial investigations focused on discovering the mechanisms causing rising rates of antibiotic resistance in N. gonorrhoeae by determining differences in peptidoglycan composition in penicillin susceptible and resistant strains.
Ryan E, Schaub, Joseph P, Dillard
openaire +2 more sources
mBio, 2015 Most bacterial cells are enclosed in a single macromolecule of the cell wall polymer, peptidoglycan, which is required for shape determination and maintenance of viability, while peptidoglycan biosynthesis is an important antibiotic target.
Richard Wheeler +9 more
doaj +1 more source
PLoS ONE, 2021 Daptomycin is a cyclic lipopeptide antibiotic used in the clinic for treatment of severe enterococcal infections. Recent reports indicate that daptomycin targets active cellular processes, specifically, peptidoglycan biosynthesis. Within, we examined the
Rachel D Johnston +4 more
doaj +1 more source
Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs) [PDF]
Proceedings of the National Academy of Sciences, 2006 The innate immune system constitutes the first line of defense against microorganisms in both vertebrates and invertebrates. Although much progress has been made toward identifying key receptors and understanding their role in host defense, far less is known about how these receptors recognize microbial ligands. Such studies have been severely hampered
Swaminathan, Chittoor P. +8 more
openaire +3 more sources