Results 21 to 30 of about 111,225 (303)
Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex [PDF]
, 2013 Background: MurE controls stereo chemical incorporation of Lysine or diaminopimelate into peptidoglycan stem peptides Results: The structure of S.aureus MurE reveals an unexpected lack of specificity for Lysine within the active site.
Roper, David I +14 more
core +1 more source
Peptidoglycan-Directed Chemical Ligation for Selective Inhibition on Gram-Positive Bacteria
, 2022 Microbicides with distinct antibacterial mechanisms show potential to combat multi-drug resistance bacteria. We herein report peptidoglycan-directed chemical ligation (PGCL) between alkyne-bearing vancomycin and an azide-tagged cationic polymer.
Xinhui Su (1341387) +9 more
core +1 more source
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum
mBio, 2019 Chlamydiales species are obligate intracellular bacteria lacking a classical peptidoglycan sacculus but relying on peptidoglycan synthesis for cytokinesis.
Nicolas Jacquier +5 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 IntroductionMycobacteria assemble a complex cell wall with cross-linked peptidoglycan (PG) which plays an essential role in maintenance of cell wall integrity and tolerance to osmotic pressure.
Moagi T. Shaku +6 more
doaj +1 more source
Frontiers in Microbiology, 2018 Peptidoglycan is the fundamental structural constituent of the bacterial cell wall. Despite many years of research, the architecture of peptidoglycan is still largely elusive.
Kang Li +12 more
doaj +1 more source
Innate Immunity, 2020 Defensins are critical components of the innate immune system and play an important role in the integration of innate and adaptive immune responses.
Juan Huang +6 more
doaj +1 more source
Structural basis for peptidoglycan binding by peptidoglycan recognition proteins [PDF]
Proceedings of the National Academy of Sciences, 2004 Peptidoglycan (PGN) recognition proteins (PGRPs) are pattern-recognition receptors of the innate immune system that bind and, in some cases, hydrolyze bacterial PGNs. We determined the crystal structure, at 2.30-Å resolution, of the C-terminal PGN-binding domain of human PGRP-Iα in complex with a muramyl tripeptide representing the core of
Rongjin, Guan +5 more
openaire +2 more sources
Digestion of Peptidoglycan and Analysis of Soluble Fragments
Bio-Protocol, 2017 Peptidoglycan (murein) is a vital component of the cell wall of nearly all bacteria, composed of sugars linked by short peptides. This protocol describes the purification of macromolecular peptidoglycan from cultured bacteria and the analysis of enzyme ...
Ryan Schaub, Joseph Dillard
doaj +1 more source
Microbiology Spectrum, 2015 ABSTRACT Bacterial endospores possess multiple integument layers, one of which is the cortex peptidoglycan wall. The cortex is essential for the maintenance of spore core dehydration and dormancy and contains structural modifications that differentiate it from vegetative cell peptidoglycan and determine its fate during spore ...
David L, Popham, Casey B, Bernhards
openaire +2 more sources
Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]
, 2013 ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep +29 more
core +1 more source