How innate immunity proteins kill bacteria and why they are not prone to resistance [PDF]
, 2017 Recent advances on antibacterial activity of peptidoglycan recognition proteins (PGRPs) offer some insight into how innate immunity has retained its antimicrobial effectiveness for millions of years with no frequent emergence of resistant strains. First,
Dziarski, Roman, Gupta, Dipika
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Digestion of Peptidoglycan and Analysis of Soluble Fragments
Bio-Protocol, 2017 Peptidoglycan (murein) is a vital component of the cell wall of nearly all bacteria, composed of sugars linked by short peptides. This protocol describes the purification of macromolecular peptidoglycan from cultured bacteria and the analysis of enzyme ...
Ryan Schaub, Joseph Dillard
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Kytococcus aerolatus sp. nov., isolated from indoor air in a room colonized with moulds [PDF]
, 2009 A Gram-positive, coccoid bacterial isolate (02-St-019/1(T)), forming beige pigmented colonies was obtained from an indoor air sample. Based on 16S rRNA gene sequence similarity studies it was determined that this isolate 02-St-019/1(T) belonged to the ...
Kämpfer, Peter +3 more
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Microbiology Spectrum, 2015 ABSTRACT Bacterial endospores possess multiple integument layers, one of which is the cortex peptidoglycan wall. The cortex is essential for the maintenance of spore core dehydration and dormancy and contains structural modifications that differentiate it from vegetative cell peptidoglycan and determine its fate during spore ...
David L, Popham, Casey B, Bernhards
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Structural basis for peptidoglycan binding by peptidoglycan recognition proteins [PDF]
Proceedings of the National Academy of Sciences, 2004 Peptidoglycan (PGN) recognition proteins (PGRPs) are pattern-recognition receptors of the innate immune system that bind and, in some cases, hydrolyze bacterial PGNs. We determined the crystal structure, at 2.30-Å resolution, of the C-terminal PGN-binding domain of human PGRP-Iα in complex with a muramyl tripeptide representing the core of
Rongjin, Guan +5 more
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Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. [PDF]
, 2017 Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Blecha, Joseph E +10 more
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Are the immunomodulatory properties of Lactobacillus rhamnosus CRL1505 peptidoglycan common for all Lactobacilli during respiratory infection in malnourished mice? [PDF]
, 2018 Previously, we reported that Lactobacillus rhamnosus CRL1505 peptidoglycan (PG05) improves the innate immune response in immunocompromised-malnourished mice after Streptococcus pneumoniae infection.
Alvarez, Gladis Susana +3 more
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Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 [PDF]
, 2020 Cyanobacteria are key organisms in the global ecosystem, useful models for studying metabolic and physiological processes conserved in photosynthetic organisms, and potential renewable platforms for production of chemicals.
Lea-Smith, David +2 more
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Composition of dissolved organic matter within a lacustrine environment [PDF]
, 2011 Freshwater dissolved organic matter (DOM) is a complex mixture of chemical components that are central to many environmental processes, including carbon and nitrogen cycling.
Adrian Spence +61 more
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Clostridioides difficile peptidoglycan modifications
Current Opinion in Microbiology, 2022 The cortex and peptidoglycan of Clostridioides difficile have been poorly investigated. This last decade, the interest increased because these two structures are highly modified and these modifications may be involved in antimicrobial resistance. For example, C.
Coullon, Héloïse, Candela, Thomas
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